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PAK1

Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.

Function, Activation/inhibition & Interactions

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Function

20 related topics

Activation/inhibition

27 related topics

Interactions

11 related topics

Gene and spliced variants

8 related topics

Key facts & relationships

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2.7.11.1
Aliases
PAK1, PAKalpha, p21 (RAC1) activated kinase 1, IDDMSSD
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F3M, 1YHW, 1ZSG, 2HY8, 2QME, 3DVP, 3FXZ, 3FY0, 3Q4Z, 3Q52, 3Q53, 4DAW, 4EQC, 4O0R, 4O0T, 4P90, 4ZJI, 4ZJJ,…
Band
11q13.5-q14.1 · 7 E1|7 53.57 cM
Bgee
middle temporal gyrus · Brodmann area 23 · monocyte · endothelial cell · pons
BioGPS
More reference expression data

Topics to explore

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Overview

Discovery

Function

Gene and spliced variants

Protein domains

Activation/inhibition

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

PAK1

Nodes92
Edges91
Triples269
Avg. degree1.98
Density0.021739
Components1

How this topic connects Entity context

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PAK1

Top relations

Gene ontology · 84
PAK1 → actin cytoskeleton reorganization, actin filament, activation of protein kinase activity, apoptotic process, ATP binding, axon, branching morphogenesis of an epithelial tube, catalytic activity, cell junction, cell migration, cell projection, cell-cell junction, cellular response to DNA damage stimulus, cellular response to insulin stimulus, cerebellum development, chromatin remodeling, chromosome, collagen binding, cytoplasm, cytosol
related to Downstream effector targets · 41
PAK1 → Arpc1b-T21, BAD-S111, BAD-S112, C-terminal, CRKII-S41, CW-type, DLC1-S88, ErbB3, Estrogen, Ets, FilaminA-S2152, Functions, Histone H3-S10, MEK1-S298, Merlin-S518, MORC, Paxillin-S258, Paxillin-S273, Raf1-S338, RC
Bgee · 19
PAK1 → anterior horn of spinal cord, Brodmann area 23, cerebellar cortex, cerebellar hemisphere, endothelial cell, facial motor nucleus, genital tubercle, inferior colliculi, lateral nuclear group of thalamus, middle temporal gyrus, monocyte, motor neuron, piriform cortex, pons, pontine nuclei, right frontal lobe, right hemisphere of cerebellum, visual cortex, zygote
RNA expression pattern · 19
PAK1 → anterior horn of spinal cord, Brodmann area 23, cerebellar cortex, cerebellar hemisphere, endothelial cell, facial motor nucleus, genital tubercle, inferior colliculi, lateral nuclear group of thalamus, middle temporal gyrus, monocyte, motor neuron, piriform cortex, pons, pontine nuclei, right frontal lobe, right hemisphere of cerebellum, visual cortex, zygote
related to Upstream activators · 15
PAK1 → B-Raf, C-X-C, Endothelial Tyrosine Kinase, Epithelial, Extracellular Signal-Regulated Kinase, II, JAK2, Kaposi's, Klotho, N-acetylglucosaminyl, Protein, Rac3, RhoI, STE20-related, Vascular
related to Function · 11
PAK1 → Alternative, Cdc42, GTP, PAK, PAK2, PAK3, PAK4, Rac, Rho GTPases, Stimulation, These
related to Interactions · 10
PAK1 → ARHGEF2, ARPC1B, BMX, C-Raf, CDC42, Cyclin-dependent, DYNLL1, LIMK1, NCK1, PAK1IP1
related to Discovery · 9
PAK1 → Cdc42, Colleagues, DNA, GTP-dependent, Manser, Martin, Rac1, Rho GTPases, The
related to Activation/inhibition · 8
PAK1 → GTPase, Inhibition, IPA-3, PAK, PDGF-stimulated ERK, Preactivated PAK1, Reversible, The AID
related to Gene and spliced variants · 8
PAK1 → Alternative, Only, RNA, RNAs, Six, The, Unlike, UTR

Important terminology Word statistics

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Important terminology

gene kinase human bp cellular activity pak proteins expression cell chr serine chromosome band effector signaling growth transcripts cancer processes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PAK12.7.11.11.00infobox
PAK1AliasesPAK1, PAKalpha, p21 (RAC1) activated kinase 1, IDDMSSD1.00infobox
PAK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F3M, 1YHW, 1ZSG, 2HY8, 2QME, 3DVP, 3FXZ, 3FY0, 3Q4Z, 3Q52, 3Q53, 4DAW, 4EQC, 4O0R, 4O0T, 4P90, 4ZJI, 4ZJJ,…1.00infobox
PAK1Band11q13.5-q14.11.00infobox
PAK1Band7 E1|7 53.57 cM1.00infobox
PAK1Bgeemiddle temporal gyrus1.00infobox
PAK1BgeeBrodmann area 231.00infobox
PAK1Bgeemonocyte1.00infobox
PAK1Bgeeendothelial cell1.00infobox
PAK1Bgeepons1.00infobox
PAK1Bgeecerebellar cortex1.00infobox
PAK1Bgeecerebellar hemisphere1.00infobox
PAK1Bgeeright hemisphere of cerebellum1.00infobox
PAK1Bgeeright frontal lobe1.00infobox
PAK1Bgeelateral nuclear group of thalamus1.00infobox
PAK1Bgeefacial motor nucleus1.00infobox
PAK1Bgeemotor neuron1.00infobox
PAK1Bgeepontine nuclei1.00infobox
PAK1Bgeezygote1.00infobox
PAK1Bgeeanterior horn of spinal cord1.00infobox
PAK1Bgeeinferior colliculi1.00infobox
PAK1Bgeepiriform cortex1.00infobox
PAK1Bgeegenital tubercle1.00infobox
PAK1Bgeevisual cortex1.00infobox
PAK1BioGPSMore reference expression data1.00infobox
PAK1Chr.Chromosome 11 (human)1.00infobox
PAK1Chr.Chromosome 7 (mouse)1.00infobox
PAK1DatabasesNCBI: entry; OMA: entry1.00infobox
PAK1End77,474,635 bp1.00infobox
PAK1End97,561,588 bp1.00infobox

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