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Transforming growth factor beta: Standards, Clinical significance & Signaling pathways

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.

Language: English [EN]
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Transforming growth factor beta topic overview

The analysis highlights Standards, Clinical significance and Signaling pathways as prominent areas in the source structure around Transforming growth factor beta.

Related topics
102
Source areas
10
Connected nodes
112
Extracted relationships
13
Concept neighborhoods
38
Bridge connections
112

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 35 topics
Overview · 25 topics
Signaling pathways · 13 topics
Structure · 11 topics
Effects on immune cells · 9 topics
Integrin-independent activation · 3 topics
Latent TGF-β complex · 2 topics
TGF-β mimic · 2 topics
Activation by Alpha(V) containing integrins · 1 topics
TGFβ receptor inhibitors · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Latent TGF-β complex

Integrin-independent activation

Activation by Alpha(V) containing integrins

Signaling pathways

TGFβ receptor inhibitors

TGF-β mimic

Effects on immune cells

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Transforming growth factor beta connects Entity context

See recurring relationship patterns around Transforming growth factor beta before inspecting the individual extracted relationships.

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tgf-β cells cell signaling complex also pathway latent role tgf-β1 protein activation macrophages receptor immune lap active may kinase proteins

Transforming growth factor beta relationships Subject–Predicate–Object triples

TTTA extracted 13 structured relationships around Transforming growth factor beta. Examples in this analysis include plasmin catalyze the release of active TGF-β from the complex → instance of → Serum proteinases and epidermal growth factor → instance of → ERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
plasmin catalyze the release of active TGF-β from the complexinstance ofSerum proteinases0.80text
epidermal growth factorinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
whereas the JNKinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
p38 MAPK are activated by the MAPK kinaseinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
activated themselves by the TGF-β-activated kinase-1instance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
c-mycinstance ofand repressing other key regulatory genes0.80text
ATMinstance ofand repressing other key regulatory genes0.80text
IL-10instance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
IL-35instance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
and TGF-β.Liver fibrosisTGF-β1 has been implicated in the process of activating hepatic stellate cellsinstance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
mitral valve prolapseinstance ofectopia lentis and heart complications0.80text
aortic enlargement increasing the likelihood of aortic dissectioninstance ofectopia lentis and heart complications0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Transforming growth factor beta bring nearby vocabulary together. In this analysis, examples include Transcription, Kinase and Activate. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • tgf-β superfamily
    • Cells
    • Role
    • Also
    • May
    • Pathway
    • Macrophages
    • Levels
    • Shown
    • Lap
    • Activation
    • Latent
    • Immune
  • signaling proteins
    • Pathway
    • Tgf-β
    • Cancer
    • Cell
    • Transcription
    • Receptor
    • Also
    • Proteins
    • Signaling
    • Kinase
    • Immune
    • Protein
  • white blood cell
    • Pathway
    • Immune
    • Complex
    • Tgf-β
    • Signaling
    • Apoptosis
    • Cancer
    • Kinase
    • Cells
    • Activation
    • Latent
    • Role
  • tgf-β receptors
    • Binding
    • Cells
    • Type
    • Role
    • Also
    • Activation
    • May
    • Pathway
    • Macrophages
    • Levels
    • Shown
    • Lap
  • signaling cascade
    • Pathway
    • Tgf-β
    • Cancer
    • Cell
    • Receptor
    • Also
    • Proteins
    • Kinase
    • Immune
    • Role
    • Cells
    • Receptors
  • latent tgf-beta binding protein
    • Receptor
    • Receptors
    • Type
    • Tgf-β1
    • Macrophages
    • Protein
    • Lap
    • Latent
    • Kinase
    • Pathway
    • Transcription
    • Activate
  • stem cell
    • Pathway
    • Immune
    • Complex
    • Tgf-β
    • Signaling
    • Apoptosis
    • Cancer
    • Kinase
    • Cells
    • Activation
    • Latent
    • Role
  • activated complex
    • Latent
    • Lap
    • Protein
    • Release
    • Differentiation
    • Factor
    • Receptors
    • Activate
    • Tgf-β
    • Kinase
    • Active
    • Macrophages

Connections between topic areas Semantic bridges

For Transforming growth factor beta, one of the stronger structural bridges in this analysis connects Transforming growth factor beta with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Transforming growth factor beta — Clinical significance · splits 77 ⟂ 36
Transforming growth factor beta — Overview · splits 87 ⟂ 26
Transforming growth factor beta — Signaling pathways · splits 99 ⟂ 14
Transforming growth factor beta — Structure · splits 101 ⟂ 12
Transforming growth factor beta — Effects on immune cells · splits 103 ⟂ 10
Transforming growth factor beta — Integrin-independent activation · splits 109 ⟂ 4
Transforming growth factor beta — Latent TGF-β complex · splits 110 ⟂ 3
Transforming growth factor beta — TGF-β mimic · splits 110 ⟂ 3

Map overview Semantic statistics

Transforming growth factor beta

Nodes113
Edges112
Triples13
Avg. degree1.98
Density0.017699
Components1

Source & methodology

TTTA analyzes the structure around Transforming growth factor beta to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Signaling pathways, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Transforming growth factor beta · EN edition · Analysis: TopicsToTalkAbout

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