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PAK4

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.

Interactions, Inhibitors & Gene and spliced variants

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Interactions

3 related topics

Inhibitors

2 related topics

Gene and spliced variants

1 related topics

Protein domains

1 related topics

Key facts & relationships

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2.7.11.1
Aliases
PAK4, p21 (RAC1) activated kinase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67,…
Band
19q13.2 · 7|7 A3- B1
Bgee
beta cell · olfactory bulb · thoracic diaphragm · mucosa of transverse colon · right uterine tube
BioGPS
More reference expression data

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Overview

Gene and spliced variants

Protein domains

Regulation

Inhibitors

Function

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

PAK4

Nodes25
Edges24
Triples175
Avg. degree1.92
Density0.08
Components1

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PAK4

Top relations

Gene ontology · 33
PAK4 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cadherin binding involved in cell-cell adhesion, cell cycle, cell growth, cell migration, cell population proliferation, cell-cell adhesion, cellular response to organic cyclic compound, cytoplasm, cytoskeleton organization, dendritic spine development, focal adhesion, Golgi apparatus, kinase activity, negative regulation of endothelial cell apoptotic process, nucleotide binding, phosphorylation
Bgee · 20
PAK4 → anterior pituitary, beta cell, epithelium of stomach, hand, mucosa of transverse colon, myocardium of left ventricle, olfactory bulb, otolith organ, parotid gland, primary oocyte, right lung, right uterine tube, secondary oocyte, tail of embryo, thoracic diaphragm, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, yolk sac, zygote
RNA expression pattern · 20
PAK4 → anterior pituitary, beta cell, epithelium of stomach, hand, mucosa of transverse colon, myocardium of left ventricle, olfactory bulb, otolith organ, parotid gland, primary oocyte, right lung, right uterine tube, secondary oocyte, tail of embryo, thoracic diaphragm, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, yolk sac, zygote
related to Function · 16
PAK4 → Cdc42, Cdc42Hs, Examples, GTP, GTP-bound, JNK, MAP, Multiple, PAK, PAK1, PAK2, PAK3, PAK4-regulated, Rac, Rho GTPases, They
related to Regulation · 14
PAK4 → CDK5RAP3, GEF-H1-Ser810, HGF, In, LIMK1-Thr508, PKA, PKD, SCG10, Ser288, Ser50, Ser675, Ser759/Ser762, SH3RF2, Smad2-Ser465
related to External links · 11
PAK4 → Cell Migration Gateway Archived, O96013, Overview, PAK, PAK4 Info, PDB, PDBe-KB, Serine/threonine-protein, UCSC Genome Browser, UniProt, Wayback MachinePAK4
related to Inhibitors · 8
PAK4 → GL-1196, GNE-2861, Inka1, KY-04031, KY-04045, LCH-7749944, PF-3758309, The PAK4
related to Gene and spliced variants · 6
PAK4 → II PAKs, In, PAKs, RNA, The, The PAK4
related to Protein domains · 6
PAK4 → AID, AID-like, C-terminal, PBD, PS, The
related to Discovery · 4
PAK4 → Group II PAK, Jurkett, Minden, PCR-based

Important terminology Word statistics

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Important terminology

gene human bp pak kinase serine chr band expression activity chromosome 19 cytoskeleton cell signaling cellular location proteins pak1 domains

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PAK42.7.11.11.00infobox
PAK4AliasesPAK4, p21 (RAC1) activated kinase 41.00infobox
PAK4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67,…1.00infobox
PAK4Band19q13.21.00infobox
PAK4Band7|7 A3- B11.00infobox
PAK4Bgeebeta cell1.00infobox
PAK4Bgeeolfactory bulb1.00infobox
PAK4Bgeethoracic diaphragm1.00infobox
PAK4Bgeemucosa of transverse colon1.00infobox
PAK4Bgeeright uterine tube1.00infobox
PAK4Bgeeright lung1.00infobox
PAK4Bgeeparotid gland1.00infobox
PAK4Bgeeupper lobe of left lung1.00infobox
PAK4Bgeemyocardium of left ventricle1.00infobox
PAK4Bgeeanterior pituitary1.00infobox
PAK4Bgeezygote1.00infobox
PAK4Bgeesecondary oocyte1.00infobox
PAK4Bgeeyolk sac1.00infobox
PAK4Bgeeepithelium of stomach1.00infobox
PAK4Bgeeotolith organ1.00infobox
PAK4Bgeetransitional epithelium of urinary bladder1.00infobox
PAK4Bgeehand1.00infobox
PAK4Bgeeutricle1.00infobox
PAK4Bgeetail of embryo1.00infobox
PAK4Bgeeprimary oocyte1.00infobox
PAK4BioGPSMore reference expression data1.00infobox
PAK4Chr.Chromosome 19 (human)1.00infobox
PAK4Chr.Chromosome 7 (mouse)1.00infobox
PAK4DatabasesNCBI: entry; OMA: entry1.00infobox
PAK4End39,182,816 bp1.00infobox

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