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PAK4: Interactions, Inhibitors & Gene and spliced variants

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.

Language: English [EN]
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PAK4 topic overview

The analysis highlights Interactions, Inhibitors and Gene and spliced variants as prominent areas in the source structure around PAK4.

Related topics
17
Source areas
7
Connected nodes
24
Extracted relationships
175
Concept neighborhoods
14
Bridge connections
24

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 8 topics
Interactions · 3 topics
Inhibitors · 2 topics
Function · 1 topics
Gene and spliced variants · 1 topics
Protein domains · 1 topics
Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
Aliases
PAK4, p21 (RAC1) activated kinase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67,…
Band
19q13.2 · 7|7 A3- B1
Bgee
beta cell · olfactory bulb · thoracic diaphragm · mucosa of transverse colon · right uterine tube
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene and spliced variants

Protein domains

Regulation

Inhibitors

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PAK4 connects Entity context

The extracted context around PAK4 shows recurring relationship patterns in the source. For example, PAK4 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cadherin binding involved in cell-cell adhesion, cell cycle, cell growth, cell migration, cell population proliferation, cell-cell adhesion, cellular response to organic cyclic compound, cytoplasm, cytoskeleton organization, dendritic spine development, focal adhesion, Golgi apparatus, kinase activity, negative regulation of endothelial cell apoptotic process, nucleotide binding, phosphorylation Another extracted example is PAK4 → anterior pituitary, beta cell, epithelium of stomach, hand, mucosa of transverse colon, myocardium of left ventricle, olfactory bulb, otolith organ, parotid gland, primary oocyte, right lung, right uterine tube, secondary oocyte, tail of embryo, thoracic diaphragm, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

PAK4

Top relations

Gene ontology · 33
PAK4 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cadherin binding involved in cell-cell adhesion, cell cycle, cell growth, cell migration, cell population proliferation, cell-cell adhesion, cellular response to organic cyclic compound, cytoplasm, cytoskeleton organization, dendritic spine development, focal adhesion, Golgi apparatus, kinase activity, negative regulation of endothelial cell apoptotic process, nucleotide binding, phosphorylation
Bgee · 20
PAK4 → anterior pituitary, beta cell, epithelium of stomach, hand, mucosa of transverse colon, myocardium of left ventricle, olfactory bulb, otolith organ, parotid gland, primary oocyte, right lung, right uterine tube, secondary oocyte, tail of embryo, thoracic diaphragm, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, yolk sac, zygote
RNA expression pattern · 20
PAK4 → anterior pituitary, beta cell, epithelium of stomach, hand, mucosa of transverse colon, myocardium of left ventricle, olfactory bulb, otolith organ, parotid gland, primary oocyte, right lung, right uterine tube, secondary oocyte, tail of embryo, thoracic diaphragm, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, yolk sac, zygote
related to Function · 16
PAK4 → Cdc42, Cdc42Hs, Examples, GTP, GTP-bound, JNK, MAP, Multiple, PAK, PAK1, PAK2, PAK3, PAK4-regulated, Rac, Rho GTPases, They
related to Regulation · 14
PAK4 → CDK5RAP3, GEF-H1-Ser810, HGF, In, LIMK1-Thr508, PKA, PKD, SCG10, Ser288, Ser50, Ser675, Ser759/Ser762, SH3RF2, Smad2-Ser465
related to External links · 11
PAK4 → Cell Migration Gateway Archived, O96013, Overview, PAK, PAK4 Info, PDB, PDBe-KB, Serine/threonine-protein, UCSC Genome Browser, UniProt, Wayback MachinePAK4
related to Inhibitors · 8
PAK4 → GL-1196, GNE-2861, Inka1, KY-04031, KY-04045, LCH-7749944, PF-3758309, The PAK4
related to Gene and spliced variants · 6
PAK4 → II PAKs, In, PAKs, RNA, The, The PAK4
related to Protein domains · 6
PAK4 → AID, AID-like, C-terminal, PBD, PS, The
related to Discovery · 4
PAK4 → Group II PAK, Jurkett, Minden, PCR-based

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp pak kinase serine chr band expression activity chromosome 19 cytoskeleton cell signaling cellular location proteins pak1 domains

PAK4 relationships Subject–Predicate–Object triples

TTTA extracted 175 structured relationships around PAK4. Examples in this analysis include PAK4 → 2.7.11.1 → ↗ and PAK4 → Aliases → PAK4, p21 (RAC1) activated kinase 4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PAK42.7.11.11.00infobox
PAK4AliasesPAK4, p21 (RAC1) activated kinase 41.00infobox
PAK4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67,…1.00infobox
PAK4Band19q13.21.00infobox
PAK4Band7|7 A3- B11.00infobox
PAK4Bgeebeta cell1.00infobox
PAK4Bgeeolfactory bulb1.00infobox
PAK4Bgeethoracic diaphragm1.00infobox
PAK4Bgeemucosa of transverse colon1.00infobox
PAK4Bgeeright uterine tube1.00infobox
PAK4Bgeeright lung1.00infobox
PAK4Bgeeparotid gland1.00infobox
PAK4Bgeeupper lobe of left lung1.00infobox
PAK4Bgeemyocardium of left ventricle1.00infobox
PAK4Bgeeanterior pituitary1.00infobox
PAK4Bgeezygote1.00infobox
PAK4Bgeesecondary oocyte1.00infobox
PAK4Bgeeyolk sac1.00infobox
PAK4Bgeeepithelium of stomach1.00infobox
PAK4Bgeeotolith organ1.00infobox
PAK4Bgeetransitional epithelium of urinary bladder1.00infobox
PAK4Bgeehand1.00infobox
PAK4Bgeeutricle1.00infobox
PAK4Bgeetail of embryo1.00infobox
PAK4Bgeeprimary oocyte1.00infobox
PAK4BioGPSMore reference expression data1.00infobox
PAK4Chr.Chromosome 19 (human)1.00infobox
PAK4Chr.Chromosome 7 (mouse)1.00infobox
PAK4DatabasesNCBI: entry; OMA: entry1.00infobox
PAK4End39,182,816 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PAK4 bring nearby vocabulary together. In this analysis, examples include Human, Gene and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PAK4
    • Human
    • Gene
    • Activity
    • Shown
    • Expression
    • Serine
    • Domains
    • Family
    • Kinases
    • Pak1
    • Phosphorylation
    • Threonine
  • pak4
    • Human
    • Gene
    • Activity
    • Shown
    • Expression
    • Serine
    • Domains
    • Family
    • Kinases
    • Pak1
    • Phosphorylation
    • Threonine
  • gene
    • Location
    • Human
    • Ucsc
    • Chromosome
    • Bp
    • Cell
    • Chr
    • Expression
    • Kinase
    • Mouse
    • Pak4
    • Protein
  • cytoplasm
    • Mouse
    • Protein
    • Regulation
    • Actin
    • Domains
    • Group
    • Growth
    • Ii
    • Phosphorylation
    • Threonine
    • Ucsc
    • Band
  • cytoskeleton
    • Signaling
    • Actin
    • Growth
    • Expression
    • Pak
    • Metastasis
    • Mouse
    • Protein
    • Regulation
    • Gene
    • Group
    • Ii
  • gene expression
    • Location
    • Human
    • Growth
    • Ucsc
    • Chromosome
    • Signaling
    • Bp
    • Cell
    • Chr
    • Expression
    • Gene
    • Kinase
  • kinase
    • Serine
    • Enzyme
    • Protein
    • Regulation
    • Pak
    • Domains
    • Chromosome
    • Location
    • Gene
    • Activity
    • Bp
    • Chr
  • gene and spliced variants
    • Location
    • Human
    • Ucsc
    • Chromosome
    • Bp
    • Cell
    • Chr
    • Expression
    • Kinase
    • Mouse
    • Pak4
    • Protein

Connections between topic areas Semantic bridges

For PAK4, one of the stronger structural bridges in this analysis connects PAK4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PAK4Overview · splits 16 ⟂ 9
PAK4Interactions · splits 21 ⟂ 4
PAK4Inhibitors · splits 22 ⟂ 3

Map overview Semantic statistics

PAK4

Nodes25
Edges24
Triples175
Avg. degree1.92
Density0.08
Components1

Source & methodology

TTTA analyzes the structure around PAK4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Inhibitors & Gene and spliced variants, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PAK4 · EN edition · Analysis: TopicsToTalkAbout

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