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PAK2

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.

Discovery, Gene and spliced variants & Upstream activators

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Discovery

1 related topics

Gene and spliced variants

1 related topics

Upstream activators

1 related topics

Overview

3 related topics

Key facts & relationships

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2.7.11.1
Aliases
PAK2, PAK65, PAKgamma, p21 (RAC1) activated kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3PCS
Band
3q29 · 16 B2|16 22.4 cM
Bgee
ganglionic eminence · corpus callosum · ventricular zone · monocyte · superficial temporal artery
BioGPS
More reference expression data

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Overview

Discovery

Gene and spliced variants

Upstream activators

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Map overview Semantic statistics

PAK2

Nodes11
Edges10
Triples177
Avg. degree1.82
Density0.181818
Components1

How this topic connects Entity context

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PAK2

Top relations

Gene ontology · 53
PAK2 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cadherin binding, catalytic activity, cell migration, cellular response to organic cyclic compound, cytoplasm, cytosol, dendritic spine development, Fc-epsilon receptor signaling pathway, glutamatergic synapse, identical protein binding, interleukin-12-mediated signaling pathway, kinase activity, membrane, metabolism, mitigation of host defenses by virus, negative regulation of apoptotic process
related to Downstream targets · 21
PAK2 → ADAM10, BCL-ABL-mediated, Caspase-7, Jun, Myc, PAK2-mediated, Paxillin, S239, S272, S274, S30, S518, S779, STAT5, T173, T2, T286, T358-S373-T400, T8, T89
Bgee · 20
PAK2 → Achilles tendon, aortic valve, ascending aorta, buccal mucosa cell, ciliary body, corpus callosum, Epithelium of choroid plexus, ganglionic eminence, granulocyte, Ileal epithelium, monocyte, Paneth cell, pericardium, renal corpuscle, retinal pigment epithelium, stromal cell of endometrium, superficial temporal artery, utricle, ventricular zone, vestibular membrane of cochlear duct
RNA expression pattern · 20
PAK2 → Achilles tendon, aortic valve, ascending aorta, buccal mucosa cell, ciliary body, corpus callosum, Epithelium of choroid plexus, ganglionic eminence, granulocyte, Ileal epithelium, monocyte, Paneth cell, pericardium, renal corpuscle, retinal pigment epithelium, stromal cell of endometrium, superficial temporal artery, utricle, ventricular zone, vestibular membrane of cochlear duct
related to Protein domains · 11
PAK2 → AID, CDC42, GTP, PAK, PAK1, PBD, RAC1, Rho GTPases, Similar, The, The PAK
related to External links · 9
PAK2 → Cell Migration Gateway Archived, PAK, PAK2 Info, PDB, PDBe-KB, Q13177, Serine/threonine-protein, UniProt, Wayback MachineOverview
related to Inhibitors · 8
PAK2 → For, FRAX1036, FRAX597, Insulin, NF2, PAK-inhibitors, PAK1, The
related to Gene and spliced variants · 5
PAK2 → Gene, RNA, The, The PAK2, There
related to Discovery · 3
PAK2 → Cdc42, Rac, The
Band · 2
PAK2 → 16 B2|16 22.4 cM, 3q29

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Important terminology

gene kinase activity pak bp serine human chr band activated protein kinases chromosome threonine signaling apoptosis cells cancer phosphorylation cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PAK22.7.11.11.00infobox
PAK2AliasesPAK2, PAK65, PAKgamma, p21 (RAC1) activated kinase 21.00infobox
PAK2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3PCS1.00infobox
PAK2Band3q291.00infobox
PAK2Band16 B2|16 22.4 cM1.00infobox
PAK2Bgeeganglionic eminence1.00infobox
PAK2Bgeecorpus callosum1.00infobox
PAK2Bgeeventricular zone1.00infobox
PAK2Bgeemonocyte1.00infobox
PAK2Bgeesuperficial temporal artery1.00infobox
PAK2BgeeEpithelium of choroid plexus1.00infobox
PAK2Bgeestromal cell of endometrium1.00infobox
PAK2BgeeAchilles tendon1.00infobox
PAK2Bgeepericardium1.00infobox
PAK2Bgeebuccal mucosa cell1.00infobox
PAK2BgeePaneth cell1.00infobox
PAK2Bgeegranulocyte1.00infobox
PAK2BgeeIleal epithelium1.00infobox
PAK2Bgeeretinal pigment epithelium1.00infobox
PAK2Bgeeaortic valve1.00infobox
PAK2Bgeeciliary body1.00infobox
PAK2Bgeevestibular membrane of cochlear duct1.00infobox
PAK2Bgeerenal corpuscle1.00infobox
PAK2Bgeeutricle1.00infobox
PAK2Bgeeascending aorta1.00infobox
PAK2BioGPSMore reference expression data1.00infobox
PAK2Chr.Chromosome 3 (human)1.00infobox
PAK2Chr.Chromosome 16 (mouse)1.00infobox
PAK2DatabasesNCBI: entry; OMA: entry1.00infobox
PAK2End196,832,647 bp1.00infobox

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