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PAK5: Function, Clinical significance & Discovery

Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene.

Language: English [EN]
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PAK5 topic overview

The analysis highlights Function, Clinical significance and Discovery as prominent areas in the source structure around PAK5.

Related topics
59
Source areas
8
Connected nodes
67
Extracted relationships
125
Concept neighborhoods
28
Bridge connections
67

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Clinical significance · 8 topics
Discovery · 7 topics
Downstream targets · 7 topics
Gene and spliced variants · 7 topics
Upstream regulators · 7 topics
Overview · 6 topics
Protein domains · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
Aliases
PAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F57
Band
20p12.2 · 2|2 F3
Bgee
middle temporal gyrus · ganglionic eminence · Brodmann area 23 · cerebellar vermis · endothelial cell
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Gene and spliced variants

Protein domains

Function

Upstream regulators

Downstream targets

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PAK5 connects Entity context

The extracted context around PAK5 shows recurring relationship patterns in the source. For example, PAK5 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cell growth, cell migration, cell population proliferation, cytoplasm, cytoskeleton organization, kinase activity, learning, locomotory behavior, memory, mitochondrion, negative regulation of extrinsic apoptotic signaling pathway, nucleoplasm, nucleotide binding, nucleus, phosphorylation, protein binding Another extracted example is PAK5 → Brodmann area 23, Brodmann area 46, buccal mucosa cell, cerebellar hemisphere, cerebellar vermis, endothelial cell, ganglionic eminence, lumbar subsegment of spinal cord, middle temporal gyrus, prefrontal cortex, primary motor cortex, primary oocyte, primary visual cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, superior frontal gyrus, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

PAK5

Top relations

Gene ontology · 32
PAK5 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cell growth, cell migration, cell population proliferation, cytoplasm, cytoskeleton organization, kinase activity, learning, locomotory behavior, memory, mitochondrion, negative regulation of extrinsic apoptotic signaling pathway, nucleoplasm, nucleotide binding, nucleus, phosphorylation, protein binding
Bgee · 18
PAK5 → Brodmann area 23, Brodmann area 46, buccal mucosa cell, cerebellar hemisphere, cerebellar vermis, endothelial cell, ganglionic eminence, lumbar subsegment of spinal cord, middle temporal gyrus, prefrontal cortex, primary motor cortex, primary oocyte, primary visual cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, superior frontal gyrus, zygote
RNA expression pattern · 18
PAK5 → Brodmann area 23, Brodmann area 46, buccal mucosa cell, cerebellar hemisphere, cerebellar vermis, endothelial cell, ganglionic eminence, lumbar subsegment of spinal cord, middle temporal gyrus, prefrontal cortex, primary motor cortex, primary oocyte, primary visual cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, superior frontal gyrus, zygote
related to Downstream targets · 12
PAK5 → BAD, Epithelial-mesenchymal, GATA1, In, MARK2/Par1, Pacsin-1, PAK5-mediated, S112, S161, S187, S288, Synaptojanin-1
related to Gene and spliced variants · 7
PAK5 → Alternative, Gene, PAK, RNA, The, The PAK5, UTR
related to Discovery · 4
PAK5 → ERK, JNK, Selectivity, The PAK5
related to Protein domains · 4
PAK5 → CDC42/Rac1, CRIB, PAK4, Similar
related to Upstream regulators · 4
PAK5 → Aurora-A, CRNDE, RNA Colorectal, The
Band · 2
PAK5 → 20p12.2, 2|2 F3
Chr. · 2
PAK5 → Chromosome 2 (mouse), Chromosome 20 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene kinase bp chr human band protein pak serine enzyme chromosome 20 cell family activity expression binding location kinases rac1

PAK5 relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around PAK5. Examples in this analysis include PAK5 → 2.7.11.1 → ↗ and PAK5 → Aliases → PAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PAK52.7.11.11.00infobox
PAK5AliasesPAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 51.00infobox
PAK5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F571.00infobox
PAK5Band20p12.21.00infobox
PAK5Band2|2 F31.00infobox
PAK5Bgeemiddle temporal gyrus1.00infobox
PAK5Bgeeganglionic eminence1.00infobox
PAK5BgeeBrodmann area 231.00infobox
PAK5Bgeecerebellar vermis1.00infobox
PAK5Bgeeendothelial cell1.00infobox
PAK5Bgeeprimary visual cortex1.00infobox
PAK5BgeeBrodmann area 461.00infobox
PAK5Bgeebuccal mucosa cell1.00infobox
PAK5Bgeecerebellar hemisphere1.00infobox
PAK5Bgeeprefrontal cortex1.00infobox
PAK5Bgeelumbar subsegment of spinal cord1.00infobox
PAK5Bgeezygote1.00infobox
PAK5BgeeRostral migratory stream1.00infobox
PAK5Bgeesecondary oocyte1.00infobox
PAK5Bgeeprimary motor cortex1.00infobox
PAK5Bgeeprimary oocyte1.00infobox
PAK5Bgeeretinal pigment epithelium1.00infobox
PAK5Bgeesuperior frontal gyrus1.00infobox
PAK5BioGPSMore reference expression data1.00infobox
PAK5Chr.Chromosome 20 (human)1.00infobox
PAK5Chr.Chromosome 2 (mouse)1.00infobox
PAK5DatabasesNCBI: entry; OMA: entry1.00infobox
PAK5End9,839,076 bp1.00infobox
PAK5End136,229,887 bp1.00infobox
PAK5EnsemblENSG000001013491.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PAK5 bring nearby vocabulary together. In this analysis, examples include Gene, Activity and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PAK5
    • Gene
    • Activity
    • Cancer
    • Cells
    • Protein
    • Expression
    • One
    • Rna
    • Serine
    • Three
    • Binding
    • Cell
  • pak5
    • Gene
    • Activity
    • Cancer
    • Cells
    • Protein
    • Expression
    • One
    • Rna
    • Serine
    • Three
    • Binding
    • Cell
  • gene
    • Protein
    • Pak5
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Pak
    • Function
    • Mouse
    • Synapse
    • Kinase
  • serine
    • Species
    • Threonine
    • Cytoplasm
    • Function
    • Learning
    • Memory
    • Mouse
    • Synapse
    • Expressed
    • Expression
    • Location
    • Phosphorylation
  • threonine
    • Species
    • Serine
    • Cytoplasm
    • Function
    • Learning
    • Memory
    • Mouse
    • Synapse
    • Enzyme
    • Expressed
    • Expression
    • Kinases
  • neuronal cells
    • Expressed
    • Expression
    • Rna
    • Cancer
    • Cytoplasm
    • Function
    • Learning
    • Memory
    • Mouse
    • Species
    • Synapse
    • Threonine
  • jnk kinase
    • Rac1
    • Binding
    • Function
    • Cdc42
    • Enzyme
    • Expressed
    • Location
    • Serine
    • Signaling
    • Pak5
    • Gene
    • Activity
  • cell survival
    • Signaling
    • Cancer
    • Cells
    • Cytoplasm
    • Function
    • Kinase
    • Learning
    • Memory
    • Mouse
    • Species
    • Synapse
    • Threonine

Connections between topic areas Semantic bridges

For PAK5, one of the stronger structural bridges in this analysis connects PAK5 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PAK5Function · splits 53 ⟂ 15
PAK5Clinical significance · splits 59 ⟂ 9
PAK5Discovery · splits 60 ⟂ 8
PAK5Gene and spliced variants · splits 60 ⟂ 8
PAK5Upstream regulators · splits 60 ⟂ 8
PAK5Downstream targets · splits 60 ⟂ 8
PAK5Overview · splits 61 ⟂ 7
PAK5Protein domains · splits 64 ⟂ 4

Map overview Semantic statistics

PAK5

Nodes68
Edges67
Triples125
Avg. degree1.97
Density0.029412
Components1

Source & methodology

TTTA analyzes the structure around PAK5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PAK5 · EN edition · Analysis: TopicsToTalkAbout

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