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PAK5

Serine/threonine-protein kinase PAK 5 is an enzyme that in humans is encoded by the PAK5 gene.

Function, Clinical significance & Discovery

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2.7.11.1
Aliases
PAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F57
Band
20p12.2 · 2|2 F3
Bgee
middle temporal gyrus · ganglionic eminence · Brodmann area 23 · cerebellar vermis · endothelial cell
BioGPS
More reference expression data

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Overview

Discovery

Gene and spliced variants

Protein domains

Function

Upstream regulators

Downstream targets

Clinical significance

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Map overview Semantic statistics

PAK5

Nodes68
Edges67
Triples125
Avg. degree1.97
Density0.029412
Components1

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PAK5

Top relations

Gene ontology · 32
PAK5 → actin cytoskeleton organization, activation of protein kinase activity, apoptotic process, ATP binding, cell growth, cell migration, cell population proliferation, cytoplasm, cytoskeleton organization, kinase activity, learning, locomotory behavior, memory, mitochondrion, negative regulation of extrinsic apoptotic signaling pathway, nucleoplasm, nucleotide binding, nucleus, phosphorylation, protein binding
Bgee · 18
PAK5 → Brodmann area 23, Brodmann area 46, buccal mucosa cell, cerebellar hemisphere, cerebellar vermis, endothelial cell, ganglionic eminence, lumbar subsegment of spinal cord, middle temporal gyrus, prefrontal cortex, primary motor cortex, primary oocyte, primary visual cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, superior frontal gyrus, zygote
RNA expression pattern · 18
PAK5 → Brodmann area 23, Brodmann area 46, buccal mucosa cell, cerebellar hemisphere, cerebellar vermis, endothelial cell, ganglionic eminence, lumbar subsegment of spinal cord, middle temporal gyrus, prefrontal cortex, primary motor cortex, primary oocyte, primary visual cortex, retinal pigment epithelium, Rostral migratory stream, secondary oocyte, superior frontal gyrus, zygote
related to Downstream targets · 12
PAK5 → BAD, Epithelial-mesenchymal, GATA1, In, MARK2/Par1, Pacsin-1, PAK5-mediated, S112, S161, S187, S288, Synaptojanin-1
related to Gene and spliced variants · 7
PAK5 → Alternative, Gene, PAK, RNA, The, The PAK5, UTR
related to Discovery · 4
PAK5 → ERK, JNK, Selectivity, The PAK5
related to Protein domains · 4
PAK5 → CDC42/Rac1, CRIB, PAK4, Similar
related to Upstream regulators · 4
PAK5 → Aurora-A, CRNDE, RNA Colorectal, The
Band · 2
PAK5 → 20p12.2, 2|2 F3
Chr. · 2
PAK5 → Chromosome 2 (mouse), Chromosome 20 (human)

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Important terminology

gene kinase bp chr human band protein pak serine enzyme chromosome 20 cell family activity expression binding location kinases rac1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PAK52.7.11.11.00infobox
PAK5AliasesPAK5, PAK7, p21 (RAC1) activated kinase 7, p21 (RAC1) activated kinase 51.00infobox
PAK5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F571.00infobox
PAK5Band20p12.21.00infobox
PAK5Band2|2 F31.00infobox
PAK5Bgeemiddle temporal gyrus1.00infobox
PAK5Bgeeganglionic eminence1.00infobox
PAK5BgeeBrodmann area 231.00infobox
PAK5Bgeecerebellar vermis1.00infobox
PAK5Bgeeendothelial cell1.00infobox
PAK5Bgeeprimary visual cortex1.00infobox
PAK5BgeeBrodmann area 461.00infobox
PAK5Bgeebuccal mucosa cell1.00infobox
PAK5Bgeecerebellar hemisphere1.00infobox
PAK5Bgeeprefrontal cortex1.00infobox
PAK5Bgeelumbar subsegment of spinal cord1.00infobox
PAK5Bgeezygote1.00infobox
PAK5BgeeRostral migratory stream1.00infobox
PAK5Bgeesecondary oocyte1.00infobox
PAK5Bgeeprimary motor cortex1.00infobox
PAK5Bgeeprimary oocyte1.00infobox
PAK5Bgeeretinal pigment epithelium1.00infobox
PAK5Bgeesuperior frontal gyrus1.00infobox
PAK5BioGPSMore reference expression data1.00infobox
PAK5Chr.Chromosome 20 (human)1.00infobox
PAK5Chr.Chromosome 2 (mouse)1.00infobox
PAK5DatabasesNCBI: entry; OMA: entry1.00infobox
PAK5End9,839,076 bp1.00infobox
PAK5End136,229,887 bp1.00infobox
PAK5EnsemblENSG000001013491.00infobox

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