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Regulatory T cell

The regulatory T cells (Tregs /ˈtiːrɛɡ/ or Treg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. Treg cells are immunosuppressive and generally suppress or downregulate induction and proliferation of effector T cells. Treg…

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Development

Bone marrowThymusCD8TCRMHC
26 related topics

Natural and induced regulatory T cells

OntogenyLymph nodesInflammationNeuropilin-1Epigenetic
21 related topics

Function

Autoimmune diseasesIPEX syndromeIn vitroInterleukin 35Interleukin 10
18 related topics

Disease

RetroviralTuberculosisLeishmaniaMalariaHIV
15 related topics

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Overview

Populations

  • Tr1 Type 1 regulatory T cell

Development

Function

Natural and induced regulatory T cells

Disease

Molecular characterization

Genetic deficiency

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Regulatory T cell

Nodes143
Edges142
Triples129
Avg. degree1.99
Density0.013986
Components1

How this topic connects Entity context

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Regulatory T cell

Top relations

related to Molecular characterization · 34
Regulatory T cell → As, CD127, CD25, CD3, CD4, CD4-expressing, CD8, CTLA-4, Expression, FOXP3, Foxp3-expressing, FOXP3-expressing CD4, GITR, However, If, II, IL-17-mediated, IL-2, IL-7RA, In
related to Induced T regulatory cells · 26
Regulatory T cell → Acute, CD161, CD25, CD4, CTLA4, Epigenetic, FOXP3, FOXP3 Treg-Specific, Heligmosomoides, Hp-TGM, Hp-TGM-induced, IL-6, Induced, It, TCR, TGF-beta, TGF-β, TGF-β-induced Tregs, Th1, Th17
related to Populations · 17
Regulatory T cell → Additional, Another, CD25, CD28, CD4, CD8, FOXP3, In, Qa-1, Regulatory, Th3, The, These Treg, This, Tr1, Treg17, Tregs
related to Genetic deficiency · 14
Regulatory T cell → An, Coombs-positive, Enteropathy X-linked, FOXP3, FOXP3-mutant, Genetic, Humans, Immune, IPEX, Most, Polyendocrinopathy, The, The IPEX, This
related to Infections · 13
Regulatory T cell → Additionally, CD4, CD8, Experimental, For, HIV, Leishmania, SIV, Some Treg, They, Thus, Treg, Upon
related to Cancer · 6
Regulatory T cell → CD25, CD4, CD70, FOXP3, Hodgkin, Increased
related to Epitopes · 5
Regulatory T cell → IgG, Potential, Regulatory, Since, Tregitopes
related to Disease · 2
Regulatory T cell → An, While
related to Pregnancy · 2
Regulatory T cell → Research, While

Important terminology Word statistics

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Important terminology

cells treg regulatory foxp3 cd25 tregs cell rorγt cd4 immune expression thymus also cancer development high express may effector il-2

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
the intestinal barrierinstance ofThese cells are associated with the functions of mucosal lymphoid tissues0.80text
the cytokine IL-10instance ofOne mechanism is the production of suppressive molecules0.80text
colorectal carcinomainstance ofThis trend is seen in cancers0.80text
follicular lymphomainstance ofThis trend is seen in cancers0.80text
IL-10instance ofmight be involved in the gastric cancer progression through influencing Treg function and the secretion of immunomodulatory cytokines0.80text
IL-35instance ofmight be involved in the gastric cancer progression through influencing Treg function and the secretion of immunomodulatory cytokines0.80text
and TGF-β.Treg cells present in the TME can be either induced Tregs or naturalinstance ofmight be involved in the gastric cancer progression through influencing Treg function and the secretion of immunomodulatory cytokines0.80text
CTLA-4instance ofmany immunotherapy treatments are now incorporating Treg depletion.Cancer therapies targeting regulatory T lymphocytesTregs in the TME are abundantly effector Tregs that over-ex…0.80text
CTLA-4instance ofCancer therapies targeting regulatory T lymphocytesTregs in the TME are abundantly effector Tregs that over-express immunosuppressive molecules0.80text
during an immune response to a pathogeninstance ofThis is problematic as CD25 is also expressed on non-regulatory T cells in the setting of immune activation0.80text
Regulatory T cellrelated to CancerCD40.60section
Regulatory T cellrelated to CancerIncreased0.60section

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