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Dicer: Applications & Art

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments…

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Dicer topic overview

The analysis highlights Applications and Art as prominent areas in the source structure around Dicer.

Related topics
90
Source areas
8
Connected nodes
98
Extracted relationships
245
Concept neighborhoods
28
Bridge connections
98

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Roles in mammalian disease · 18 topics
Discovery · 16 topics
Overview · 13 topics
Diagnostic and therapeutic applications · 10 topics
Dicer proteins in insects · 10 topics
Roles in RNA interference · 9 topics
Plant Dicer-like (DCL) proteins · 8 topics
Functional domains · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.26.3
Aliases
DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
Band
14q32.13 · 12 E|12 54.83 cM
Bgee
tail of epididymis · caput epididymis · optic nerve · trabecular bone · corpus epididymis
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Functional domains

Roles in RNA interference

Roles in mammalian disease

Diagnostic and therapeutic applications

Dicer proteins in insects

Plant Dicer-like (DCL) proteins

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dicer connects Entity context

The extracted context around Dicer shows recurring relationship patterns in the source. For example, Dicer → apoptotic DNA fragmentation, ARC complex, ATP binding, axon, cytoplasm, cytosol, dendrite, deoxyribonuclease I activity, DNA binding, double-stranded RNA binding, endonuclease activity, endoplasmic reticulum-Golgi intermediate compartment, endoribonuclease activity, endoribonuclease activity, producing 5'-phosphomonoesters, extracellular exosome, gene silencing, growth cone, helicase activity, hydrolase activity, metal ion binding Another extracted example is Dicer → abdominal wall, caput epididymis, corpus epididymis, genital tubercle, inferior ganglion of vagus nerve, mandibular prominence, medullary collecting duct, mucosa of paranasal sinus, optic nerve, oral cavity, parietal pleura, primary oocyte, primitive streak, renal corpuscle, secondary oocyte, tail of embryo, tail of epididymis, trabecular bone, visceral pleura, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dicer

Top relations

Gene ontology · 48
Dicer → apoptotic DNA fragmentation, ARC complex, ATP binding, axon, cytoplasm, cytosol, dendrite, deoxyribonuclease I activity, DNA binding, double-stranded RNA binding, endonuclease activity, endoplasmic reticulum-Golgi intermediate compartment, endoribonuclease activity, endoribonuclease activity, producing 5'-phosphomonoesters, extracellular exosome, gene silencing, growth cone, helicase activity, hydrolase activity, metal ion binding
Bgee · 20
Dicer → abdominal wall, caput epididymis, corpus epididymis, genital tubercle, inferior ganglion of vagus nerve, mandibular prominence, medullary collecting duct, mucosa of paranasal sinus, optic nerve, oral cavity, parietal pleura, primary oocyte, primitive streak, renal corpuscle, secondary oocyte, tail of embryo, tail of epididymis, trabecular bone, visceral pleura, zygote
RNA expression pattern · 20
Dicer → abdominal wall, caput epididymis, corpus epididymis, genital tubercle, inferior ganglion of vagus nerve, mandibular prominence, medullary collecting duct, mucosa of paranasal sinus, optic nerve, oral cavity, parietal pleura, primary oocyte, primitive streak, renal corpuscle, secondary oocyte, tail of embryo, tail of epididymis, trabecular bone, visceral pleura, zygote
related to Dicer proteins in insects · 19
Dicer → Aedes, As, Dicer-1, Dicer-2, Drosophila, Heliothis, In Drosophila, Insects, RISC, RNA, RNAi, RNAs, RNase III, Similarly, The RNAi, This, Transmission, West Nile, While
related to Discovery · 17
Dicer → Bernstein, Cold Spring Harbor Laboratory, DCL1b, Dicer's, Drosophila CG4792, Emily Bernstein, Gregory Hannon's, In, Physcomitrella, RISC, RNA, RNAi, RNase III, Stony Brook PhD, Subsequent, This, Thus
related to Functional domains · 17
Dicer → Current, DICER1, Drosophila, DUF283, Human Dicer, In, It, Loqs, PAZ, Piwi/Argonaute/Zwille, R2D2, Ribonuclease III, RNA, RNaseIII, The, This, TRBP
related to Plant Dicer-like (DCL) proteins · 16
Dicer → Arabidopsis, DCL, DCL1, DCL2, DCL3, DCL3b, DCL4, DCL5, Dicer-like, Dicer-like-encoding, Dicers, DNA, For, Originally, Plant, The
related to Macular degeneration · 13
Dicer → Age, Alu RNA, Dicer's, Dicer-knockout, Drosha, However, Mice, Pasha, RNA, RNAi, RPE, These, This
related to Cancer · 10
Dicer → Accumulation, Additionally, Altered, Decreased Dicer, DNA, For, However, In, RNAi, This
related to Viral pathogenesis · 9
Dicer → Another, HIV-1, In, Infection, Inhibition, It, RISC, RNA, RNAi

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rna risc mirna expression sirna mrna gene dsrna rnai domains small mirnas human interference iii proteins domain fragments bp viral

Dicer relationships Subject–Predicate–Object triples

TTTA extracted 245 structured relationships around Dicer. Examples in this analysis include Dicer → 3.1.26.3 → ↗ and Dicer → Aliases → DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dicer3.1.26.31.00infobox
DicerAliasesDICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW1.00infobox
DicerAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ1.00infobox
DicerBand14q32.131.00infobox
DicerBand12 E|12 54.83 cM1.00infobox
DicerBgeetail of epididymis1.00infobox
DicerBgeecaput epididymis1.00infobox
DicerBgeeoptic nerve1.00infobox
DicerBgeetrabecular bone1.00infobox
DicerBgeecorpus epididymis1.00infobox
DicerBgeemucosa of paranasal sinus1.00infobox
DicerBgeevisceral pleura1.00infobox
DicerBgeeoral cavity1.00infobox
DicerBgeeparietal pleura1.00infobox
DicerBgeeinferior ganglion of vagus nerve1.00infobox
DicerBgeezygote1.00infobox
DicerBgeesecondary oocyte1.00infobox
DicerBgeeprimary oocyte1.00infobox
DicerBgeetail of embryo1.00infobox
DicerBgeegenital tubercle1.00infobox
DicerBgeemandibular prominence1.00infobox
DicerBgeemedullary collecting duct1.00infobox
DicerBgeerenal corpuscle1.00infobox
DicerBgeeabdominal wall1.00infobox
DicerBgeeprimitive streak1.00infobox
DicerBioGPSn/a1.00infobox
DicerChr.Chromosome 14 (human)1.00infobox
DicerChr.Chromosome 12 (mouse)1.00infobox
DicerDatabasesNCBI: entry; OMA: entry1.00infobox
DicerEnd95,158,010 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dicer bring nearby vocabulary together. In this analysis, examples include Rna, Expression and Iii. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dicer
    • Rna
    • Expression
    • Iii
    • Mirna
    • Sirna
    • Dsrna
    • Risc
    • Cancer
    • Function
    • Human
    • Involved
    • Protein
  • dicer
    • Rna
    • Expression
    • Iii
    • Mirna
    • Sirna
    • Dsrna
    • Risc
    • Cancer
    • Function
    • Human
    • Involved
    • Protein
  • enzyme
    • Dicer1
    • Rnase
    • Fragments
    • Iii
    • Small
    • Domains
    • Gene
    • Dsrna
    • Risc
    • Rna
    • Bp
    • Chr
  • gene
    • Interference
    • Human
    • Mrna
    • Bp
    • Chr
    • Specific
    • Expression
    • Mirnas
    • Silencing
    • Iii
    • Band
    • Rna
  • rnase iii
    • Rnase
    • Human
    • Interfering
    • Double-stranded
    • Interference
    • Rna
    • Small
    • Domains
    • Risc
    • Bp
    • Chr
    • Pre-mirna
  • double-stranded rna
    • Interfering
    • Small
    • Pre-mirna
    • Interference
    • Fragments
    • Iii
    • Risc
    • Rna
    • Mrna
    • Function
    • Complex
    • Human
  • small interfering rna
    • Small
    • Interference
    • Risc
    • Pre-mirna
    • Mrna
    • Human
    • Interfering
    • Rna
    • Complex
    • Fragments
    • Dsrna
    • Mirnas
  • rna-induced silencing complex
    • Risc
    • Silencing
    • Rna
    • Domain
    • Mirnas
    • Sirna
    • Interference
    • Mrna
    • Rnai
    • Band
    • Dicer1
    • Bp

Connections between topic areas Semantic bridges

For Dicer, one of the stronger structural bridges in this analysis connects Dicer with Roles in mammalian disease. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DicerRoles in mammalian disease · splits 80 ⟂ 19
DicerDiscovery · splits 82 ⟂ 17
DicerOverview · splits 85 ⟂ 14
DicerDiagnostic and therapeutic applications · splits 88 ⟂ 11
DicerDicer proteins in insects · splits 88 ⟂ 11
DicerRoles in RNA interference · splits 89 ⟂ 10
DicerPlant Dicer-like (DCL) proteins · splits 90 ⟂ 9
DicerFunctional domains · splits 92 ⟂ 7

Map overview Semantic statistics

Dicer

Nodes99
Edges98
Triples245
Avg. degree1.98
Density0.020202
Components1

Source & methodology

TTTA analyzes the structure around Dicer to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dicer · EN edition · Analysis: TopicsToTalkAbout

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