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Dicer

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments…

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3.1.26.3
Aliases
DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
Band
14q32.13 · 12 E|12 54.83 cM
Bgee
tail of epididymis · caput epididymis · optic nerve · trabecular bone · corpus epididymis
BioGPS
n/a

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Overview

Discovery

Functional domains

Roles in RNA interference

Roles in mammalian disease

Diagnostic and therapeutic applications

Dicer proteins in insects

Plant Dicer-like (DCL) proteins

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Map overview Semantic statistics

Dicer

Nodes99
Edges98
Triples245
Avg. degree1.98
Density0.020202
Components1

How this topic connects Entity context

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Dicer

Top relations

Gene ontology · 48
Dicer → apoptotic DNA fragmentation, ARC complex, ATP binding, axon, cytoplasm, cytosol, dendrite, deoxyribonuclease I activity, DNA binding, double-stranded RNA binding, endonuclease activity, endoplasmic reticulum-Golgi intermediate compartment, endoribonuclease activity, endoribonuclease activity, producing 5'-phosphomonoesters, extracellular exosome, gene silencing, growth cone, helicase activity, hydrolase activity, metal ion binding
Bgee · 20
Dicer → abdominal wall, caput epididymis, corpus epididymis, genital tubercle, inferior ganglion of vagus nerve, mandibular prominence, medullary collecting duct, mucosa of paranasal sinus, optic nerve, oral cavity, parietal pleura, primary oocyte, primitive streak, renal corpuscle, secondary oocyte, tail of embryo, tail of epididymis, trabecular bone, visceral pleura, zygote
RNA expression pattern · 20
Dicer → abdominal wall, caput epididymis, corpus epididymis, genital tubercle, inferior ganglion of vagus nerve, mandibular prominence, medullary collecting duct, mucosa of paranasal sinus, optic nerve, oral cavity, parietal pleura, primary oocyte, primitive streak, renal corpuscle, secondary oocyte, tail of embryo, tail of epididymis, trabecular bone, visceral pleura, zygote
related to Dicer proteins in insects · 19
Dicer → Aedes, As, Dicer-1, Dicer-2, Drosophila, Heliothis, In Drosophila, Insects, RISC, RNA, RNAi, RNAs, RNase III, Similarly, The RNAi, This, Transmission, West Nile, While
related to Discovery · 17
Dicer → Bernstein, Cold Spring Harbor Laboratory, DCL1b, Dicer's, Drosophila CG4792, Emily Bernstein, Gregory Hannon's, In, Physcomitrella, RISC, RNA, RNAi, RNase III, Stony Brook PhD, Subsequent, This, Thus
related to Functional domains · 17
Dicer → Current, DICER1, Drosophila, DUF283, Human Dicer, In, It, Loqs, PAZ, Piwi/Argonaute/Zwille, R2D2, Ribonuclease III, RNA, RNaseIII, The, This, TRBP
related to Plant Dicer-like (DCL) proteins · 16
Dicer → Arabidopsis, DCL, DCL1, DCL2, DCL3, DCL3b, DCL4, DCL5, Dicer-like, Dicer-like-encoding, Dicers, DNA, For, Originally, Plant, The
related to Macular degeneration · 13
Dicer → Age, Alu RNA, Dicer's, Dicer-knockout, Drosha, However, Mice, Pasha, RNA, RNAi, RPE, These, This
related to Cancer · 10
Dicer → Accumulation, Additionally, Altered, Decreased Dicer, DNA, For, However, In, RNAi, This
related to Viral pathogenesis · 9
Dicer → Another, HIV-1, In, Infection, Inhibition, It, RISC, RNA, RNAi

Important terminology Word statistics

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Important terminology

rna risc mirna expression sirna mrna gene dsrna rnai domains small mirnas human interference iii proteins domain fragments bp viral

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dicer3.1.26.31.00infobox
DicerAliasesDICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW1.00infobox
DicerAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ1.00infobox
DicerBand14q32.131.00infobox
DicerBand12 E|12 54.83 cM1.00infobox
DicerBgeetail of epididymis1.00infobox
DicerBgeecaput epididymis1.00infobox
DicerBgeeoptic nerve1.00infobox
DicerBgeetrabecular bone1.00infobox
DicerBgeecorpus epididymis1.00infobox
DicerBgeemucosa of paranasal sinus1.00infobox
DicerBgeevisceral pleura1.00infobox
DicerBgeeoral cavity1.00infobox
DicerBgeeparietal pleura1.00infobox
DicerBgeeinferior ganglion of vagus nerve1.00infobox
DicerBgeezygote1.00infobox
DicerBgeesecondary oocyte1.00infobox
DicerBgeeprimary oocyte1.00infobox
DicerBgeetail of embryo1.00infobox
DicerBgeegenital tubercle1.00infobox
DicerBgeemandibular prominence1.00infobox
DicerBgeemedullary collecting duct1.00infobox
DicerBgeerenal corpuscle1.00infobox
DicerBgeeabdominal wall1.00infobox
DicerBgeeprimitive streak1.00infobox
DicerBioGPSn/a1.00infobox
DicerChr.Chromosome 14 (human)1.00infobox
DicerChr.Chromosome 12 (mouse)1.00infobox
DicerDatabasesNCBI: entry; OMA: entry1.00infobox
DicerEnd95,158,010 bp1.00infobox

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