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Microprocessor complex subunit DGCR8

The microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) is a protein that in humans is encoded by the DGCR8 gene. In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha). It is a required component of the RNA interference pathway.

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Aliases
DGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X47, 2YT4, 3LE4, 5B16
Band
22q11.21
Bgee
right hemisphere of cerebellum · sural nerve · right testis · left testis · body of uterus
BioGPS
More reference expression data
Chr.
Chromosome 22 (human)

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Microprocessor complex subunit DGCR8

Nodes24
Edges23
Triples59
Avg. degree1.92
Density0.083333
Components1

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Microprocessor complex subunit DGCR8

Top relations

Gene ontology · 20
Microprocessor complex subunit DGCR8 → cytoplasm, double-stranded RNA binding, heme binding, identical protein binding, metal ion binding, microprocessor complex, miRNA metabolic process, nucleolus, nucleoplasm, nucleus, postsynaptic density, primary miRNA binding, primary miRNA processing, protein binding, protein homodimerization activity, regulation of stem cell proliferation, ribonuclease III activity, RNA binding, RNA phosphodiester bond hydrolysis, RNA phosphodiester bond hydrolysis, endonucleolytic
Bgee · 10
Microprocessor complex subunit DGCR8 → apex of heart, body of pancreas, body of uterus, left ovary, left testis, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, right testis, sural nerve
RNA expression pattern · 10
Microprocessor complex subunit DGCR8 → apex of heart, body of pancreas, body of uterus, left ovary, left testis, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, right testis, sural nerve
Aliases · 1
Microprocessor complex subunit DGCR8 → DGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit
Available structures · 1
Microprocessor complex subunit DGCR8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X47, 2YT4, 3LE4, 5B16
Band · 1
Microprocessor complex subunit DGCR8 → 22q11.21
BioGPS · 1
Microprocessor complex subunit DGCR8 → More reference expression data
Chr. · 1
Microprocessor complex subunit DGCR8 → Chromosome 22 (human)
Databases · 1
Microprocessor complex subunit DGCR8 → NCBI: entry; OMA: entry
End · 1
Microprocessor complex subunit DGCR8 → 20,111,877 bp

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Important terminology

dgcr8 protein microprocessor complex subunit human bp gene required drosha chr chromosome 22 function known rna band mirna processing pasha

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Microprocessor complex subunit DGCR8AliasesDGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit1.00infobox
Microprocessor complex subunit DGCR8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X47, 2YT4, 3LE4, 5B161.00infobox
Microprocessor complex subunit DGCR8Band22q11.211.00infobox
Microprocessor complex subunit DGCR8Bgeeright hemisphere of cerebellum1.00infobox
Microprocessor complex subunit DGCR8Bgeesural nerve1.00infobox
Microprocessor complex subunit DGCR8Bgeeright testis1.00infobox
Microprocessor complex subunit DGCR8Bgeeleft testis1.00infobox
Microprocessor complex subunit DGCR8Bgeebody of uterus1.00infobox
Microprocessor complex subunit DGCR8Bgeeright ovary1.00infobox
Microprocessor complex subunit DGCR8Bgeeright lobe of thyroid gland1.00infobox
Microprocessor complex subunit DGCR8Bgeebody of pancreas1.00infobox
Microprocessor complex subunit DGCR8Bgeeleft ovary1.00infobox
Microprocessor complex subunit DGCR8Bgeeapex of heart1.00infobox
Microprocessor complex subunit DGCR8BioGPSMore reference expression data1.00infobox
Microprocessor complex subunit DGCR8Chr.Chromosome 22 (human)1.00infobox
Microprocessor complex subunit DGCR8DatabasesNCBI: entry; OMA: entry1.00infobox
Microprocessor complex subunit DGCR8End20,111,877 bp1.00infobox
Microprocessor complex subunit DGCR8EnsemblENSG000001281911.00infobox
Microprocessor complex subunit DGCR8Entrez544871.00infobox
Microprocessor complex subunit DGCR8External IDsOMIM: 609030; MGI: 2151114; GeneCards: DGCR81.00infobox
Microprocessor complex subunit DGCR8Gene location (Human)Gene location (Human)Chr.Chromosome 22 (human)Band22q11.21Start20,080,232 bpEnd20,111,877 bp1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyprimary miRNA binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyribonuclease III activity1.00infobox
Microprocessor complex subunit DGCR8Gene ontologydouble-stranded RNA binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyprotein binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyheme binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyprotein homodimerization activity1.00infobox
Microprocessor complex subunit DGCR8Gene ontologymetal ion binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyRNA binding1.00infobox
Microprocessor complex subunit DGCR8Gene ontologyidentical protein binding1.00infobox

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