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Neuronal calcium sensor-1: History, Function & Structure

Neuronal calcium sensor-1 (NCS-1) also known as frequenin homolog (Drosophila) (freq) is a protein that is encoded by the FREQ gene in humans. NCS-1 is a member of the neuronal calcium sensor family, a class of EF hand containing calcium-myristoyl-switch proteins.

Language: English [EN]
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Neuronal calcium sensor-1 topic overview

The analysis highlights History, Function and Structure as prominent areas in the source structure around Neuronal calcium sensor-1.

Related topics
32
Source areas
5
Connected nodes
37
Extracted relationships
94
Concept neighborhoods
11
Bridge connections
37

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 21 topics
Overview · 4 topics
History · 3 topics
Clinical significance · 2 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NCS1, FLUP, FREQ, neuronal calcium sensor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GUK, 1G8I, 2LCP, 5AER, 5AFP, 5AEQ
Band
9q34.11 · 2|2 B
Bgee
right frontal lobe · anterior cingulate cortex · nucleus accumbens · amygdala · dorsolateral prefrontal cortex
BioGPS
n/a
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Clinical significance

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Neuronal calcium sensor-1 connects Entity context

The extracted context around Neuronal calcium sensor-1 shows recurring relationship patterns in the source. For example, Neuronal calcium sensor-1 → axon, calcium ion binding, calcium ion transmembrane transport, calyx of Held, cell junction, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dense core granule, glutamatergic synapse, Golgi apparatus, intracellular membrane-bounded organelle, magnesium ion binding, membrane, metal ion binding, perinuclear region of cytoplasm, phosphatidylinositol-mediated signaling, plasma membrane, positive regulation of exocytosis Another extracted example is Neuronal calcium sensor-1 → amygdala, anterior cingulate cortex, Brodmann area 9, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, dorsomedial hypothalamic nucleus, hippocampus proper, medial dorsal nucleus, medial geniculate nucleus, nucleus accumbens, olfactory tubercle, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, subiculum, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Neuronal calcium sensor-1

Top relations

Gene ontology · 33
Neuronal calcium sensor-1 → axon, calcium ion binding, calcium ion transmembrane transport, calyx of Held, cell junction, cytoplasm, cytoplasmic vesicle, cytosol, dendrite, dense core granule, glutamatergic synapse, Golgi apparatus, intracellular membrane-bounded organelle, magnesium ion binding, membrane, metal ion binding, perinuclear region of cytoplasm, phosphatidylinositol-mediated signaling, plasma membrane, positive regulation of exocytosis
Bgee · 19
Neuronal calcium sensor-1 → amygdala, anterior cingulate cortex, Brodmann area 9, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, dorsomedial hypothalamic nucleus, hippocampus proper, medial dorsal nucleus, medial geniculate nucleus, nucleus accumbens, olfactory tubercle, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, subiculum, superior frontal gyrus
RNA expression pattern · 19
Neuronal calcium sensor-1 → amygdala, anterior cingulate cortex, Brodmann area 9, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, dorsomedial hypothalamic nucleus, hippocampus proper, medial dorsal nucleus, medial geniculate nucleus, nucleus accumbens, olfactory tubercle, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, subiculum, superior frontal gyrus
Band · 2
Neuronal calcium sensor-1 → 2|2 B, 9q34.11
Chr. · 2
Neuronal calcium sensor-1 → Chromosome 2 (mouse), Chromosome 9 (human)
End · 2
Neuronal calcium sensor-1 → 130,237,303 bp, 31,186,001 bp
Aliases · 1
Neuronal calcium sensor-1 → NCS1, FLUP, FREQ, neuronal calcium sensor 1
Available structures · 1
Neuronal calcium sensor-1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GUK, 1G8I, 2LCP, 5AER, 5AFP, 5AEQ
BioGPS · 1
Neuronal calcium sensor-1 → n/a
Databases · 1
Neuronal calcium sensor-1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ncs-1 calcium bp protein also neuronal chr human band gene chromosome drosophila mouse sensor location function known containing proteins neurotransmission

Neuronal calcium sensor-1 relationships Subject–Predicate–Object triples

TTTA extracted 94 structured relationships around Neuronal calcium sensor-1. Examples in this analysis include Neuronal calcium sensor-1 → Aliases → NCS1, FLUP, FREQ, neuronal calcium sensor 1 and Neuronal calcium sensor-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GUK, 1G8I, 2LCP, 5AER, 5AFP, 5AEQ. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Neuronal calcium sensor-1AliasesNCS1, FLUP, FREQ, neuronal calcium sensor 11.00infobox
Neuronal calcium sensor-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GUK, 1G8I, 2LCP, 5AER, 5AFP, 5AEQ1.00infobox
Neuronal calcium sensor-1Band9q34.111.00infobox
Neuronal calcium sensor-1Band2|2 B1.00infobox
Neuronal calcium sensor-1Bgeeright frontal lobe1.00infobox
Neuronal calcium sensor-1Bgeeanterior cingulate cortex1.00infobox
Neuronal calcium sensor-1Bgeenucleus accumbens1.00infobox
Neuronal calcium sensor-1Bgeeamygdala1.00infobox
Neuronal calcium sensor-1Bgeedorsolateral prefrontal cortex1.00infobox
Neuronal calcium sensor-1Bgeepostcentral gyrus1.00infobox
Neuronal calcium sensor-1BgeeBrodmann area 91.00infobox
Neuronal calcium sensor-1Bgeeprefrontal cortex1.00infobox
Neuronal calcium sensor-1Bgeecaudate nucleus1.00infobox
Neuronal calcium sensor-1Bgeehippocampus proper1.00infobox
Neuronal calcium sensor-1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Neuronal calcium sensor-1Bgeesuperior frontal gyrus1.00infobox
Neuronal calcium sensor-1Bgeemedial geniculate nucleus1.00infobox
Neuronal calcium sensor-1Bgeesubiculum1.00infobox
Neuronal calcium sensor-1Bgeemedial dorsal nucleus1.00infobox
Neuronal calcium sensor-1Bgeedorsomedial hypothalamic nucleus1.00infobox
Neuronal calcium sensor-1Bgeeolfactory tubercle1.00infobox
Neuronal calcium sensor-1Bgeeprimary visual cortex1.00infobox
Neuronal calcium sensor-1Bgeecerebellar cortex1.00infobox
Neuronal calcium sensor-1BioGPSn/a1.00infobox
Neuronal calcium sensor-1Chr.Chromosome 9 (human)1.00infobox
Neuronal calcium sensor-1Chr.Chromosome 2 (mouse)1.00infobox
Neuronal calcium sensor-1DatabasesNCBI: entry; OMA: entry1.00infobox
Neuronal calcium sensor-1End130,237,303 bp1.00infobox
Neuronal calcium sensor-1End31,186,001 bp1.00infobox
Neuronal calcium sensor-1EnsemblENSG000001071301.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Neuronal calcium sensor-1 bring nearby vocabulary together. In this analysis, examples include Sensor, Gene and Neuronal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Neuronal calcium sensor-1
    • Sensor
    • Gene
    • Neuronal
    • Freq
    • Binding
    • Ef-hand
    • External
    • Kinase
    • Known
    • Ncs-1
    • Protein
    • Ef
  • neuronal calcium sensor-1
    • Protein
    • Sensor
    • Gene
    • Neuronal
    • Ef
    • Freq
    • Member
    • Ncs1
    • Search
    • Binding
    • Containing
    • Ef-hand
  • neuronal calcium sensor
    • Calcium
    • External
    • Neuronal
    • Protein
    • Sensor
    • Gene
    • Ef
    • Freq
    • Member
    • Ncs1
    • Search
    • Binding
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Mouse
    • Ncs1
    • Search
    • Function
    • Band
    • Neuronal
  • function
    • Dentate
    • Gyrus
    • Ncs1
    • Search
    • Location
    • Chromosome
    • Gene
    • Human
    • Bp
    • Chr
    • End
    • Mouse
  • dentate gyrus
    • Dentate
    • Gyrus
    • Function
    • End
    • Mouse
    • Ncs1
    • Search
    • Forms
    • Increases
    • Kinase
    • Location
    • Gene
  • drosophila
    • Neurotransmission
    • Freq
    • Frq
    • Increases
    • Known
    • Gene
    • Neuronal
    • Ncs-1
    • Protein
  • ef hand
    • Member
    • Containing
    • Ef-hand
    • Proteins
    • Sensor
    • Neuronal
    • Ncs-1

Connections between topic areas Semantic bridges

For Neuronal calcium sensor-1, one of the stronger structural bridges in this analysis connects Neuronal calcium sensor-1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Neuronal calcium sensor-1Function · splits 16 ⟂ 22
Neuronal calcium sensor-1Overview · splits 33 ⟂ 5
Neuronal calcium sensor-1History · splits 34 ⟂ 4
Neuronal calcium sensor-1Structure · splits 35 ⟂ 3
Neuronal calcium sensor-1Clinical significance · splits 35 ⟂ 3

Map overview Semantic statistics

Neuronal calcium sensor-1

Nodes38
Edges37
Triples94
Avg. degree1.95
Density0.052632
Components1

Source & methodology

TTTA analyzes the structure around Neuronal calcium sensor-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Neuronal calcium sensor-1 · EN edition · Analysis: TopicsToTalkAbout

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