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UH-232: History, Applications & Research

UH-232, or (+)-UH-232, also known as 5-hydroxy-1-methyl-2-(dipropylamino)tetralin methyl ether (5-HMDPTME), is a dopamine and serotonin receptor modulator of the 2-aminotetralin family which was under development for the treatment of schizophrenia but was never marketed. It is taken orally. Contrary to expectations, the drug did not end up producing…

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UH-232 topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around UH-232.

Related topics
83
Source areas
6
Connected nodes
89
Extracted relationships
64
Concept neighborhoods
27
Bridge connections
89

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 35 topics
Chemistry · 20 topics
Overview · 10 topics
Use and effects · 8 topics
Research · 6 topics
History · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
3.7% (rats)
CAS Number
95999-12-5 Y
ChEBI
CHEBI:114198
ChEMBL
ChEMBL278751

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Use and effects

Pharmacology

Chemistry

History

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How UH-232 connects Entity context

The extracted context around UH-232 shows recurring relationship patterns in the source. For example, UH-232 → AJ-76, Another, DOM-AT, DPT, HMDPT, In, OH-DPAT, OH-MDAT, Other, PNU-99, RDS-127, RU-28251, The N-monopropyl, UH-232RU-28251NDTDILSD, UH-242, UH-301 Another extracted example is UH-232 → Accordingly, D1, D2, D2Sh, D3, D4, However, HT1A, HT2, HT2A, In, It, Its, Ki, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

UH-232

Top relations

related to Analogues · 16
UH-232 → AJ-76, Another, DOM-AT, DPT, HMDPT, In, OH-DPAT, OH-MDAT, Other, PNU-99, RDS-127, RU-28251, The N-monopropyl, UH-232RU-28251NDTDILSD, UH-242, UH-301
related to Pharmacodynamics · 15
UH-232 → Accordingly, D1, D2, D2Sh, D3, D4, However, HT1A, HT2, HT2A, In, It, Its, Ki, The
related to Research · 5
UH-232 → Besides, Instead, It, Parkinson's, The
has effect · 3
UH-232 → Based, HT2A, The
related to history · 3
UH-232 → Arvid Carlsson, AstraZeneca, It
is a · 2
UH-232 → functional antagonist or partial agonist of the dopamine receptors in humans.In addition to the dopamine D2 and D3 receptors, substituted 2-aminotetralin
3D model (JSmol) · 1
UH-232 → Interactive image
ATC code · 1
UH-232 → None
Bioavailability · 1
UH-232 → 3.7% (rats)
CAS Number · 1
UH-232 → 95999-12-5 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dopamine effects receptor serotonin d2 hallucinogenic also d3 drug schizophrenia antagonist partial 5-ht2a treatment reported agonist 2-aminotetralin receptors 5-ht2 stimulant-like

UH-232 relationships Subject–Predicate–Object triples

TTTA extracted 64 structured relationships around UH-232. Examples in this analysis include UH-232 → 3D model (JSmol) → Interactive image and UH-232 → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
UH-2323D model (JSmol)Interactive image1.00infobox
UH-232ATC codeNone1.00infobox
UH-232Bioavailability3.7% (rats)1.00infobox
UH-232CAS Number95999-12-5 Y1.00infobox
UH-232ChEBICHEBI:1141981.00infobox
UH-232ChEMBLChEMBL2787511.00infobox
UH-232ChemSpider50370171.00infobox
UH-232CompTox Dashboard (EPA)DTXSID708751011.00infobox
UH-232Drug classDopamine D2 receptor antagonist; Dopamine D3 receptor weak partial agonist; Serotonin 5-HT2A receptor agonist; Hallucinogen; Serotonergic psychedelic1.00infobox
UH-232Elimination half-life2.5 hours (rats)1.00infobox
UH-232FormulaC18H29NO1.00infobox
UH-232MetabolitesAJ-761.00infobox
UH-232Molar mass275.436 g·mol−11.00infobox
UH-232Other namesUH232; (+)-UH-232; (+)-UH232; (+)-cis-5-Methoxy-1-methyl-2-(dipropylamino)tetralin; 5-HMDPTME; 5-Hydroxy-1-methyl-2-(dipropylamino)tetralin methyl ether1.00infobox
UH-232PubChem CID66047561.00infobox
UH-232Routes of administrationOral1.00infobox
UH-232UNIIQQYOR9S5871.00infobox
UH-232is afunctional antagonist or partial agonist of the dopamine receptors in humans.In addition to the dopamine D2 and D3 receptors0.90text
UH-232is asubstituted 2-aminotetralin0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around UH-232 bring nearby vocabulary together. In this analysis, examples include Partial, Humans and Hyperlocomotion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • dopamine
    • D2
    • Receptor
    • D3
    • Antagonist
    • Serotonin
    • Receptors
    • Uh-232
    • Affinity
    • Ki
    • 5-ht2
    • Agonist
    • Partial
  • serotonin receptor modulator
    • D2
    • D3
    • Receptor
    • Serotonin
    • 5-ht2
    • 5-ht2a
    • May
    • Tetralin
    • Affinity
    • Agonist
    • Ki
    • Receptors
  • serotonin
    • Receptor
    • 5-ht2
    • 5-ht2a
    • May
    • D2
    • Tetralin
    • D3
    • Affinity
    • Agonist
    • Receptors
    • Reported
    • Uh-232
  • 5-ht2a receptor
    • May
    • D2
    • D3
    • Serotonin
    • 5-ht2a
    • Receptor
    • Agonist
    • Reported
    • 5-ht2
    • Hallucinogenic
    • Partial
    • Affinity
  • d2
    • D3
    • Dopamine
    • Receptor
    • Affinity
    • 5-ht2
    • Receptors
    • Serotonin
    • Antagonist
    • Ki
    • Weak
    • Agonist
    • Partial
  • d3 receptor
    • D2
    • D3
    • Receptor
    • Serotonin
    • Dopamine
    • Affinity
    • 5-ht2a
    • Receptors
    • 5-ht2
    • Ki
    • Weak
    • Agonist
  • antagonist
    • Agonist
    • Dopamine
    • Partial
    • Humans
    • Weak
    • D2
    • Drug
    • D3
    • Serotonin
    • Receptor
    • Dipropylamino
    • Ether
  • partial agonist
    • Antagonist
    • Partial
    • Humans
    • Weak
    • Reported
    • 5-ht2a
    • Drug
    • Dopamine
    • Uh-232
    • D2
    • D3
    • Dipropylamino

Connections between topic areas Semantic bridges

For UH-232, one of the stronger structural bridges in this analysis connects UH-232 with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
UH-232Pharmacology · splits 54 ⟂ 36
UH-232Chemistry · splits 69 ⟂ 21
UH-232Overview · splits 79 ⟂ 11
UH-232Use and effects · splits 81 ⟂ 9
UH-232Research · splits 83 ⟂ 7
UH-232History · splits 85 ⟂ 5

Map overview Semantic statistics

UH-232

Nodes90
Edges89
Triples64
Avg. degree1.98
Density0.022222
Components1

Source & methodology

TTTA analyzes the structure around UH-232 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — UH-232 · EN edition · Analysis: TopicsToTalkAbout

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