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UH-232

UH-232, or (+)-UH-232, also known as 5-hydroxy-1-methyl-2-(dipropylamino)tetralin methyl ether (5-HMDPTME), is a dopamine and serotonin receptor modulator of the 2-aminotetralin family which was under development for the treatment of schizophrenia but was never marketed. It is taken orally. Contrary to expectations, the drug did not end up producing…

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3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
3.7% (rats)
CAS Number
95999-12-5 Y
ChEBI
CHEBI:114198
ChEMBL
ChEMBL278751

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UH-232

Nodes90
Edges89
Triples64
Avg. degree1.98
Density0.022222
Components1

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UH-232

Top relations

related to Analogues · 16
UH-232 → AJ-76, Another, DOM-AT, DPT, HMDPT, In, OH-DPAT, OH-MDAT, Other, PNU-99, RDS-127, RU-28251, The N-monopropyl, UH-232RU-28251NDTDILSD, UH-242, UH-301
related to Pharmacodynamics · 15
UH-232 → Accordingly, D1, D2, D2Sh, D3, D4, However, HT1A, HT2, HT2A, In, It, Its, Ki, The
related to Research · 5
UH-232 → Besides, Instead, It, Parkinson's, The
has effect · 3
UH-232 → Based, HT2A, The
related to history · 3
UH-232 → Arvid Carlsson, AstraZeneca, It
is a · 2
UH-232 → functional antagonist or partial agonist of the dopamine receptors in humans.In addition to the dopamine D2 and D3 receptors, substituted 2-aminotetralin
3D model (JSmol) · 1
UH-232 → Interactive image
ATC code · 1
UH-232 → None
Bioavailability · 1
UH-232 → 3.7% (rats)
CAS Number · 1
UH-232 → 95999-12-5 Y

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Important terminology

dopamine effects receptor serotonin d2 hallucinogenic also d3 drug schizophrenia antagonist partial 5-ht2a treatment reported agonist 2-aminotetralin receptors 5-ht2 stimulant-like

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
UH-2323D model (JSmol)Interactive image1.00infobox
UH-232ATC codeNone1.00infobox
UH-232Bioavailability3.7% (rats)1.00infobox
UH-232CAS Number95999-12-5 Y1.00infobox
UH-232ChEBICHEBI:1141981.00infobox
UH-232ChEMBLChEMBL2787511.00infobox
UH-232ChemSpider50370171.00infobox
UH-232CompTox Dashboard (EPA)DTXSID708751011.00infobox
UH-232Drug classDopamine D2 receptor antagonist; Dopamine D3 receptor weak partial agonist; Serotonin 5-HT2A receptor agonist; Hallucinogen; Serotonergic psychedelic1.00infobox
UH-232Elimination half-life2.5 hours (rats)1.00infobox
UH-232FormulaC18H29NO1.00infobox
UH-232MetabolitesAJ-761.00infobox
UH-232Molar mass275.436 g·mol−11.00infobox
UH-232Other namesUH232; (+)-UH-232; (+)-UH232; (+)-cis-5-Methoxy-1-methyl-2-(dipropylamino)tetralin; 5-HMDPTME; 5-Hydroxy-1-methyl-2-(dipropylamino)tetralin methyl ether1.00infobox
UH-232PubChem CID66047561.00infobox
UH-232Routes of administrationOral1.00infobox
UH-232UNIIQQYOR9S5871.00infobox
UH-232is afunctional antagonist or partial agonist of the dopamine receptors in humans.In addition to the dopamine D2 and D3 receptors0.90text
UH-232is asubstituted 2-aminotetralin0.90text

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