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Ankyrin repeat: Clinical significance, Role in protein folding & Overview

The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandem repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. They appear in bacterial…

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Ankyrin repeat topic overview

The analysis highlights Clinical significance, Role in protein folding and Overview as prominent areas in the source structure around Ankyrin repeat.

Related topics
166
Source areas
3
Connected nodes
169
Extracted relationships
29
Related term clusters
20
Bridge connections
169

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 127 topics
Overview · 26 topics
Role in protein folding · 13 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR002110 · PF00023
Available protein structures:
IPR002110 · PF00023
InterPro
IPR002110
PDB
1a5e​, 1ap7​, 1awc​, 1bd8​, 1bi7​, 1bi8​, 1blx​, 1bu9​, 1d9s​, 1dc2​, 1dcq​, 1g3n​, 1ihb​, 1ikn​, 1ixv​, 1k1a​, 1k1b​, 1k3z​, 1mx2​, 1mx4​, 1mx6​, 1myo​, 1n11​, 1nfi​, 1ot8​, 1o…
Pfam
PF00023
PROSITE
PDOC50088

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Role in protein folding

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Ankyrin repeat connects Entity context

The extracted context around Ankyrin repeat shows recurring relationship patterns in the source. For example, Ankyrin repeat → Ankyrin-repeat, CADASIL, MARPs, Notch Another extracted example is Ankyrin repeat → Ankyrin, Ankyrin-repeat, C-terminus, TPLX. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ankyrin repeat

Top relations

related to Clinical significance · 4
Ankyrin repeat → Ankyrin-repeat, CADASIL, MARPs, Notch
related to Role in protein folding · 4
Ankyrin repeat → Ankyrin, Ankyrin-repeat, C-terminus, TPLX
AlphaFold · 2
Ankyrin repeat → IPR002110, PF00023
Available protein structures: · 2
Ankyrin repeat → IPR002110, PF00023
InterPro · 1
Ankyrin repeat → IPR002110
PDB · 1
Ankyrin repeat → 1a5e​, 1ap7​, 1awc​, 1bd8​, 1bi7​, 1bi8​, 1blx​, 1bu9​, 1d9s​, 1dc2​, 1dcq​, 1g3n​, 1ihb​, 1ikn​, 1ixv​, 1k1a​, 1k1b​, 1k3z​, 1mx2​, 1mx4​, 1mx6​, 1myo​, 1n11​, 1nfi​, 1ot8​, 1o…
Pfam · 1
Ankyrin repeat → PF00023
PROSITE · 1
Ankyrin repeat → PDOC50088
SCOP2 · 1
Ankyrin repeat → 1awc / SCOPe / SUPFAM
SMART · 1
Ankyrin repeat → SM00248

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ankyrin proteins repeat protein repeats known common folding motif fold interactions structure domains structures sequence among number function eukaryotes found

Ankyrin repeat relationships Subject–Predicate–Object triples

TTTA extracted 29 structured relationships around Ankyrin repeat. Examples in this analysis include Ankyrin repeat → AlphaFold → IPR002110 and Ankyrin repeat → AlphaFold → PF00023. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ankyrin repeatAlphaFoldIPR0021101.00infobox
Ankyrin repeatAlphaFoldPF000231.00infobox
Ankyrin repeatAvailable protein structures:IPR0021101.00infobox
Ankyrin repeatAvailable protein structures:PF000231.00infobox
Ankyrin repeatInterProIPR0021101.00infobox
Ankyrin repeatPDB1a5e​, 1ap7​, 1awc​, 1bd8​, 1bi7​, 1bi8​, 1blx​, 1bu9​, 1d9s​, 1dc2​, 1dcq​, 1g3n​, 1ihb​, 1ikn​, 1ixv​, 1k1a​, 1k1b​, 1k3z​, 1mx2​, 1mx4​, 1mx6​, 1myo​, 1n11​, 1nfi​, 1ot8​, 1o…1.00infobox
Ankyrin repeatPfamPF000231.00infobox
Ankyrin repeatPROSITEPDOC500881.00infobox
Ankyrin repeatSCOP21awc / SCOPe / SUPFAM1.00infobox
Ankyrin repeatSMARTSM002481.00infobox
Ankyrin repeatSymbolAnk1.00infobox
Ankyrin repeatis a33-residue motif in proteins consisting of two alpha helices separated by loops0.90text

Related concept clusters Related term clusters

The concept neighborhoods around Ankyrin repeat bring nearby vocabulary together. In this analysis, examples include Repeats, Repeat and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ankyrin repeat
    • Repeats
    • Repeat
    • Protein
    • Motif
    • Proteins
    • Interactions
    • Known
    • Structures
    • Folding
    • Cell
    • Cycle
    • Among
  • ankyrin repeat
    • Repeats
    • Repeat
    • Protein
    • Motif
    • Proteins
    • Interactions
    • Known
    • Structures
    • Folding
    • Ankk1
    • Cell
    • Cycle
  • protein–protein interactions
    • Known
    • Motifs
    • Study
    • Repeat
    • Structures
    • Proteins
    • Repeats
    • Interactions
    • Protein
    • Folding
    • Ankk1
    • Ankyrin-repeat
  • protein design
    • Repeat
    • Proteins
    • Repeats
    • Interactions
    • Known
    • Folding
    • Ankk1
    • Ankyrin-repeat
    • Based
    • Sequence
    • Structure
    • Structures
  • role in protein folding
    • Repeat
    • Ankyrin-repeat
    • Contacts
    • Study
    • Proteins
    • Repeats
    • Sequence
    • Structures
    • Interactions
    • Known
    • Motif
    • Folding
  • proteins
    • Repeat
    • Known
    • Protein
    • Folding
    • Among
    • Number
    • Common
    • Cell
    • Consisting
    • Cycle
    • Diverse
    • Eukaryotes
  • ankyrin
    • Repeats
    • Repeat
    • Protein
    • Motif
    • Proteins
    • Interactions
    • Known
    • Structures
    • Folding
    • Among
    • Fold
    • Sequence
  • globular proteins
    • Repeat
    • Known
    • Protein
    • Folding
    • Among
    • Number
    • Common
    • Cell
    • Consisting
    • Cycle
    • Diverse
    • Eukaryotes

Connections between topic areas Semantic bridges

For Ankyrin repeat, one of the stronger structural bridges in this analysis connects Ankyrin repeat with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Ankyrin repeat — Clinical significance · splits 42 ⟂ 128
Ankyrin repeat — Overview · splits 143 ⟂ 27
Ankyrin repeat — Role in protein folding · splits 156 ⟂ 14

Map overview Semantic statistics

Ankyrin repeat

Nodes170
Edges169
Triples29
Avg. degree1.99
Density0.011765
Components1

Source & methodology

TTTA analyzes the structure around Ankyrin repeat to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Role in protein folding & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ankyrin repeat · EN edition · Analysis: TopicsToTalkAbout

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