Ankyrin repeat

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Ankyrin repeat topic overview

The analysis highlights Clinical significance, Role in protein folding and Overview as prominent areas in the source structure around Ankyrin repeat.

Related topics: 269
Source areas: 3
Connected nodes: 272
Extracted relationships: 37
Concept neighborhoods: 20
Bridge connections: 272

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 229 topics

Overview · 26 topics

Role in protein folding · 14 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold: IPR002110 · PF00023
Available protein structures:: IPR002110 · PF00023
InterPro: IPR002110
PDB: 1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…
Pfam: PF00023
PROSITE: PDOC50088

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Motif Protein motif
Proteins Protein
Alpha helices Alpha helix
Loops Loop (biochemistry)
Signaling Cell signaling
Yeast
Drosophila
Notch Notch pathway
Tandem repeats Protein tandem repeats
Protein–protein interactions Protein–protein interaction
Bacterial Bacteria
Archaeal Archaea
Eukaryotes Eukaryote
Poxviruses
Ankyrin
Giardia lamblia
Fold Protein folding
Solenoid Solenoid protein domain
Prokaryotes Prokaryote
Cell cycle
Cytoskeletal Cytoskeleton
Ion transporters Ion transporter
Signal transducers Signal transduction
Beta bulge loop
Schellman loop
N-terminus

Role in protein folding

Multiple sequence alignment
Conserved Conservation (genetics)
Amino acid
Hydrophobic
Protein design
Consensus sequence
Antibody
Globular proteins Globular protein
Tertiary structure
Residue-residue contacts Native contact
Contact order
Two-state folding Two-state folding?action=edit&redlink=1
Phi values Phi value analysis
C-terminus

Clinical significance

Diseases Disease
CDKN2A P16 (gene)
Cancer
CADASIL
Muscle
Glutamine
Lysine
ANKK1
Love style
ABTB1
ABTB2 ABTB2?action=edit&redlink=1
ACBD6 ACBD6?action=edit&redlink=1
ACTBL1 ACTBL1?action=edit&redlink=1
ANK1
ANK2
ANK3
ANKAR ANKAR?action=edit&redlink=1
ANKDD1A ANKDD1A?action=edit&redlink=1
ANKEF1 ANKEF1?action=edit&redlink=1
ANKFY1
ANKHD1
ANKIB1 ANKIB1?action=edit&redlink=1
ANKMY1
ANKMY2 ANKMY2?action=edit&redlink=1
ANKRA2 ANKRA2?action=edit&redlink=1
ANKRD1
ANKRD10 ANKRD10?action=edit&redlink=1
ANKRD11
ANKRD12 ANKRD12?action=edit&redlink=1
ANKRD13 ANKRD13?action=edit&redlink=1
ANKRD13A ANKRD13A?action=edit&redlink=1
ANKRD13B ANKRD13B?action=edit&redlink=1
ANKRD13C
ANKRD13D ANKRD13D?action=edit&redlink=1
ANKRD15
ANKRD16 ANKRD16?action=edit&redlink=1
ANKRD17
ANKRD18A ANKRD18A?action=edit&redlink=1
ANKRD18B ANKRD18B?action=edit&redlink=1
ANKRD19 ANKRD19?action=edit&redlink=1
ANKRD2
ANKRD20A1 ANKRD20A1?action=edit&redlink=1
ANKRD20A2 ANKRD20A2?action=edit&redlink=1
ANKRD20A3 ANKRD20A3?action=edit&redlink=1
ANKRD20A4 ANKRD20A4?action=edit&redlink=1
ANKRD21 ANKRD21?action=edit&redlink=1
ANKRD22
ANKRD23
ANKRD25
ANKRD26
ANKRD27
ANKRD28 ANKRD28?action=edit&redlink=1
ANKRD30A ANKRD30A?action=edit&redlink=1
ANKRD30B ANKRD30B?action=edit&redlink=1
ANKRD30BL ANKRD30BL?action=edit&redlink=1
ANKRD32 ANKRD32?action=edit&redlink=1
ANKRD33
ANKRD35
ANKRD36 ANKRD36?action=edit&redlink=1
ANKRD36B ANKRD36B?action=edit&redlink=1
ANKRD37 ANKRD37?action=edit&redlink=1
ANKRD38 ANKRD38?action=edit&redlink=1
ANKRD39 ANKRD39?action=edit&redlink=1
ANKRD40 ANKRD40?action=edit&redlink=1
ANKRD41 ANKRD41?action=edit&redlink=1
ANKRD42 ANKRD42?action=edit&redlink=1
ANKRD43 ANKRD43?action=edit&redlink=1
ANKRD44 ANKRD44?action=edit&redlink=1
ANKRD45 ANKRD45?action=edit&redlink=1
ANKRD46 ANKRD46?action=edit&redlink=1
ANKRD47 ANKRD47?action=edit&redlink=1
ANKRD49 ANKRD49?action=edit&redlink=1
Uk ANKRD49
ANKRD50 ANKRD50?action=edit&redlink=1
ANKRD52 ANKRD52?action=edit&redlink=1
ANKRD53 ANKRD53?action=edit&redlink=1
ANKRD54 ANKRD54?action=edit&redlink=1
ANKRD55 ANKRD55?action=edit&redlink=1
ANKRD56 ANKRD56?action=edit&redlink=1
ANKRD57 ANKRD57?action=edit&redlink=1
ANKRD58 ANKRD58?action=edit&redlink=1
ANKRD60 ANKRD60?action=edit&redlink=1
ANKRD6 ANKRD6?action=edit&redlink=1
ANKRD7 ANKRD7?action=edit&redlink=1
ANKRD9 ANKRD9?action=edit&redlink=1
ANKS1A
ANKS3 ANKS3?action=edit&redlink=1
ANKS4B
ANKS6 ANKS6?action=edit&redlink=1
ANKZF1
ASB1
ASB10 ASB10?action=edit&redlink=1
ASB11 ASB11?action=edit&redlink=1
ASB12 ASB12?action=edit&redlink=1
ASB13
ASB14 ASB14?action=edit&redlink=1
ASB15 ASB15?action=edit&redlink=1
ASB16 ASB16?action=edit&redlink=1
ASB2
ASB3
ASB4 ASB4?action=edit&redlink=1
ASB5 ASB5?action=edit&redlink=1
ASB6
ASB7 ASB7?action=edit&redlink=1
ASB8 ASB8?action=edit&redlink=1
ASB9 ASB9?action=edit&redlink=1
ASZ1
BARD1
BAT4
BAT8 BAT8?action=edit&redlink=1
BCL3
BCOR BCL-6 corepressor
BCORL1 BCORL1?action=edit&redlink=1
BTBD11 BTBD11?action=edit&redlink=1
CAMTA1
CAMTA2 CAMTA2?action=edit&redlink=1
CASKIN1 CASKIN1?action=edit&redlink=1
CASKIN2 CASKIN2?action=edit&redlink=1
CCM1
CDKN2B
CDKN2C
CDKN2D
CENTB1
CENTB2
CENTB5 CENTB5?action=edit&redlink=1
CENTG1
CENTG2
CENTG3
CLIP3 CLIP3?action=edit&redlink=1
CLIP4
CLPB
CTGLF1 CTGLF1?action=edit&redlink=1
CTGLF2 CTGLF2?action=edit&redlink=1
CTGLF3 CTGLF3?action=edit&redlink=1
CTGLF4 CTGLF4?action=edit&redlink=1
CTGLF5 CTGLF5?action=edit&redlink=1
CTTNBP2
DAPK1
DDEF1
ASAP2
DDEFL1 DDEFL1?action=edit&redlink=1
DGKI DGKI?action=edit&redlink=1
DGKZ
DP58 DP58?action=edit&redlink=1
DYSFIP1 DYSFIP1?action=edit&redlink=1
DZANK DZANK?action=edit&redlink=1
EHMT1
EHMT2
ESPN
FANK1 FANK1?action=edit&redlink=1
FEM1A
FEM1B FEM1B?action=edit&redlink=1
GABPB2
GIT1
GIT2
GLS GLS (gene)?action=edit&redlink=1
GLS2
HACE1
HECTD1 HECTD1?action=edit&redlink=1
IBTK IBTK?action=edit&redlink=1
ILK
INVS
KIDINS220
KRIT1
LRRK1
MAIL MAIL?action=edit&redlink=1
MIB1 MIB1 (gene)
MIB2
MPHOSPH8
MTPN
MYO16 MYO16?action=edit&redlink=1
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIL1
NFKBIL2 NFKBIL2?action=edit&redlink=1
NOTCH1
NOTCH2
NOTCH3
NOTCH4
NRARP
NUDT12
OSBPL1A
OSTF1
PLA2G6
POTE14 POTE14?action=edit&redlink=1
POTE15 POTE15?action=edit&redlink=1
POTE8 POTE8?action=edit&redlink=1
PPP1R12A
PPP1R12B
PPP1R12C
PPP1R13B
PPP1R13L
PPP1R16A PPP1R16A?action=edit&redlink=1
PPP1R16B PPP1R16B?action=edit&redlink=1
PSMD10
RAI14
RFXANK
RIPK4
RNASEL
SHANK1
SHANK2
SHANK3
SNCAIP
TA-NFKBH TA-NFKBH?action=edit&redlink=1
TEX14
TNKS
TNKS2
TNNI3K
TP53BP2
TRP7 TRP7?action=edit&redlink=1
TRPA1
TRPC3
TRPC4
TRPC5
TRPC6
TRPC7
TRPV1
TRPV2
TRPV3
TRPV4
TRPV5
TRPV6
UACA
USH1G
ZDHHC13 ZDHHC13?action=edit&redlink=1
ZDHHC17

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ankyrin repeat connects Entity context

The extracted context around Ankyrin repeat shows recurring relationship patterns in the source. For example, Ankyrin repeat → An, Ankyrin, Ankyrin-repeat, C-terminus, More, Most, Some, The, These, TPLX Another extracted example is Ankyrin repeat → Ankyrin-repeat, CADASIL, MARPs, Notch, These. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Role in protein folding · 10

Ankyrin repeat → An, Ankyrin, Ankyrin-repeat, C-terminus, More, Most, Some, The, These, TPLX

related to Clinical significance · 5

Ankyrin repeat → Ankyrin-repeat, CADASIL, MARPs, Notch, These

AlphaFold · 2

Ankyrin repeat → IPR002110, PF00023

Available protein structures: · 2

Ankyrin repeat → IPR002110, PF00023

InterPro · 1

Ankyrin repeat → IPR002110

PDB · 1

Ankyrin repeat → 1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…

Pfam · 1

Ankyrin repeat → PF00023

PROSITE · 1

Ankyrin repeat → PDOC50088

SCOP2 · 1

Ankyrin repeat → 1awc / SCOPe / SUPFAM

SMART · 1

Ankyrin repeat → SM00248

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ankyrin proteins repeat protein repeats known common folding motif fold interactions structure domains structures sequence among number function eukaryotes found

Ankyrin repeat relationships Subject–Predicate–Object triples

TTTA extracted 37 structured relationships around Ankyrin repeat. Examples in this analysis include Ankyrin repeat → AlphaFold → IPR002110 and Ankyrin repeat → AlphaFold → PF00023. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Ankyrin repeat	AlphaFold	IPR002110	1.00	infobox
Ankyrin repeat	AlphaFold	PF00023	1.00	infobox
Ankyrin repeat	Available protein structures:	IPR002110	1.00	infobox
Ankyrin repeat	Available protein structures:	PF00023	1.00	infobox
Ankyrin repeat	InterPro	IPR002110	1.00	infobox
Ankyrin repeat	PDB	1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…	1.00	infobox
Ankyrin repeat	Pfam	PF00023	1.00	infobox
Ankyrin repeat	PROSITE	PDOC50088	1.00	infobox
Ankyrin repeat	SCOP2	1awc / SCOPe / SUPFAM	1.00	infobox
Ankyrin repeat	SMART	SM00248	1.00	infobox
Ankyrin repeat	Symbol	Ank	1.00	infobox
Ankyrin repeat	is a	33-residue motif in proteins consisting of two alpha helices separated by loops	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ankyrin repeat bring nearby vocabulary together. In this analysis, examples include Repeats, Repeat and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Ankyrin repeat
- Repeats
- Repeat
- Protein
- Motif
- Proteins
- Interactions
- Known
- Structures
- Folding
- Cell
- Cycle
- Among
ankyrin repeat
- Repeats
- Repeat
- Protein
- Motif
- Proteins
- Interactions
- Known
- Structures
- Folding
- Ankk1
- Cell
- Cycle
proteins
- Repeat
- Known
- Protein
- Folding
- Among
- Number
- Common
- Cell
- Consisting
- Cycle
- Diverse
- Eukaryotes
protein–protein interactions
- Known
- Motifs
- Study
- Repeat
- Structures
- Proteins
- Repeats
- Interactions
- Protein
- Folding
- Ankk1
- Ankyrin-repeat
ankyrin
- Repeats
- Repeat
- Protein
- Motif
- Proteins
- Interactions
- Known
- Structures
- Folding
- Among
- Fold
- Sequence
protein design
- Repeat
- Proteins
- Repeats
- Interactions
- Known
- Folding
- Ankk1
- Ankyrin-repeat
- Based
- Sequence
- Structure
- Structures
globular proteins
- Repeat
- Known
- Protein
- Folding
- Among
- Number
- Common
- Cell
- Consisting
- Cycle
- Diverse
- Eukaryotes
role in protein folding
- Repeat
- Ankyrin-repeat
- Contacts
- Study
- Proteins
- Repeats
- Sequence
- Structures
- Interactions
- Known
- Motif
- Folding

Connections between topic areas Semantic bridges

For Ankyrin repeat, one of the stronger structural bridges in this analysis connects Ankyrin repeat with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Ankyrin repeat — Clinical significance · splits 43 ⟂ 230

Ankyrin repeat — Overview · splits 246 ⟂ 27

Ankyrin repeat — Role in protein folding · splits 258 ⟂ 15

Map overview Semantic statistics

Ankyrin repeat

Nodes273

Edges272

Triples37

Avg. degree1.99

Density0.007326

Components1

Source & methodology

TTTA analyzes the structure around Ankyrin repeat to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Role in protein folding & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ankyrin repeat · EN edition · Analysis: TopicsToTalkAbout