Ankyrin repeat

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Clinical significance

Diseases CDKN2A Cancer CADASIL Muscle

229 related topics

Role in protein folding

Multiple sequence alignment Conserved Amino acid Hydrophobic Protein design

14 related topics

Overview

Motif Proteins Alpha helices Loops Signaling

26 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold: IPR002110 · PF00023
Available protein structures:: IPR002110 · PF00023
InterPro: IPR002110
PDB: 1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…
Pfam: PF00023
PROSITE: PDOC50088

Topics to explore

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Overview

Motif Protein motif
Proteins Protein
Alpha helices Alpha helix
Loops Loop (biochemistry)
Signaling Cell signaling
Yeast
Drosophila
Notch Notch pathway
Tandem repeats Protein tandem repeats
Protein–protein interactions Protein–protein interaction
Bacterial Bacteria
Archaeal Archaea
Eukaryotes Eukaryote
Poxviruses
Ankyrin
Giardia lamblia
Fold Protein folding
Solenoid Solenoid protein domain
Prokaryotes Prokaryote
Cell cycle
Cytoskeletal Cytoskeleton
Ion transporters Ion transporter
Signal transducers Signal transduction
Beta bulge loop
Schellman loop
N-terminus

Role in protein folding

Multiple sequence alignment
Conserved Conservation (genetics)
Amino acid
Hydrophobic
Protein design
Consensus sequence
Antibody
Globular proteins Globular protein
Tertiary structure
Residue-residue contacts Native contact
Contact order
Two-state folding Two-state folding?action=edit&redlink=1
Phi values Phi value analysis
C-terminus

Clinical significance

Diseases Disease
CDKN2A P16 (gene)
Cancer
CADASIL
Muscle
Glutamine
Lysine
ANKK1
Love style
ABTB1
ABTB2 ABTB2?action=edit&redlink=1
ACBD6 ACBD6?action=edit&redlink=1
ACTBL1 ACTBL1?action=edit&redlink=1
ANK1
ANK2
ANK3
ANKAR ANKAR?action=edit&redlink=1
ANKDD1A ANKDD1A?action=edit&redlink=1
ANKEF1 ANKEF1?action=edit&redlink=1
ANKFY1
ANKHD1
ANKIB1 ANKIB1?action=edit&redlink=1
ANKMY1
ANKMY2 ANKMY2?action=edit&redlink=1
ANKRA2 ANKRA2?action=edit&redlink=1
ANKRD1
ANKRD10 ANKRD10?action=edit&redlink=1
ANKRD11
ANKRD12 ANKRD12?action=edit&redlink=1
ANKRD13 ANKRD13?action=edit&redlink=1

Advanced semantic analysis

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Map overview Semantic statistics

Nodes273

Edges272

Triples37

Avg. degree1.99

Density0.007326

Components1

How this topic connects Entity context

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Ankyrin repeat

Top relations

related to Role in protein folding · 10

Ankyrin repeat → An, Ankyrin, Ankyrin-repeat, C-terminus, More, Most, Some, The, These, TPLX

related to Clinical significance · 5

Ankyrin repeat → Ankyrin-repeat, CADASIL, MARPs, Notch, These

AlphaFold · 2

Ankyrin repeat → IPR002110, PF00023

Available protein structures: · 2

Ankyrin repeat → IPR002110, PF00023

InterPro · 1

Ankyrin repeat → IPR002110

PDB · 1

Ankyrin repeat → 1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…

Pfam · 1

Ankyrin repeat → PF00023

PROSITE · 1

Ankyrin repeat → PDOC50088

SCOP2 · 1

Ankyrin repeat → 1awc / SCOPe / SUPFAM

SMART · 1

Ankyrin repeat → SM00248

Important terminology Word statistics

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Important terminology

ankyrin proteins repeat protein repeats known common folding motif fold interactions structure domains structures sequence among number function eukaryotes found

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Ankyrin repeat	AlphaFold	IPR002110	1.00	infobox
Ankyrin repeat	AlphaFold	PF00023	1.00	infobox
Ankyrin repeat	Available protein structures:	IPR002110	1.00	infobox
Ankyrin repeat	Available protein structures:	PF00023	1.00	infobox
Ankyrin repeat	InterPro	IPR002110	1.00	infobox
Ankyrin repeat	PDB	1a5e, 1ap7, 1awc, 1bd8, 1bi7, 1bi8, 1blx, 1bu9, 1d9s, 1dc2, 1dcq, 1g3n, 1ihb, 1ikn, 1ixv, 1k1a, 1k1b, 1k3z, 1mx2, 1mx4, 1mx6, 1myo, 1n11, 1nfi, 1ot8, 1o…	1.00	infobox
Ankyrin repeat	Pfam	PF00023	1.00	infobox
Ankyrin repeat	PROSITE	PDOC50088	1.00	infobox
Ankyrin repeat	SCOP2	1awc / SCOPe / SUPFAM	1.00	infobox
Ankyrin repeat	SMART	SM00248	1.00	infobox
Ankyrin repeat	Symbol	Ank	1.00	infobox
Ankyrin repeat	is a	33-residue motif in proteins consisting of two alpha helices separated by loops	0.90	text

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