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TRPC3: Function, Modulators & Overview

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growth, proliferation and pathological hypertrophy. These are diacylglycerol-sensitive cation channels known to…

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TRPC3 topic overview

The analysis highlights Function, Modulators and Overview as prominent areas in the source structure around TRPC3.

Related topics
19
Source areas
3
Connected nodes
22
Extracted relationships
107
Concept neighborhoods
6
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics
Modulators · 5 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 3
Band
4q27 · 3 B|3 17.93 cM
Bgee
buccal mucosa cell · secondary oocyte · endothelial cell · pituitary gland · testicle
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Modulators

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TRPC3 connects Entity context

The extracted context around TRPC3 shows recurring relationship patterns in the source. For example, TRPC3 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation channel complex, inositol 1,4,5 trisphosphate binding, integral component of membrane, integral component of plasma membrane, ion channel activity, ion transport, manganese ion transport, membrane, phototransduction, plasma membrane, platelet activation, positive regulation of calcium ion transport into cytosol, positive regulation of cardiac muscle hypertrophy in response to stress, protein binding, regulation of cytosolic calcium ion concentration, response to ATP, response to calcium ion Another extracted example is TRPC3 → anterior pituitary, buccal mucosa cell, cerebellar vermis, endothelial cell, gastric mucosa, gonad, lateral geniculate nucleus, lateral septal nucleus, lobe of cerebellum, lumbar spinal ganglion, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, nucleus of stria terminalis, pituitary gland, putamen, secondary oocyte, superior colliculus, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

TRPC3

Top relations

Gene ontology · 23
TRPC3 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation channel complex, inositol 1,4,5 trisphosphate binding, integral component of membrane, integral component of plasma membrane, ion channel activity, ion transport, manganese ion transport, membrane, phototransduction, plasma membrane, platelet activation, positive regulation of calcium ion transport into cytosol, positive regulation of cardiac muscle hypertrophy in response to stress, protein binding, regulation of cytosolic calcium ion concentration, response to ATP, response to calcium ion
Bgee · 20
TRPC3 → anterior pituitary, buccal mucosa cell, cerebellar vermis, endothelial cell, gastric mucosa, gonad, lateral geniculate nucleus, lateral septal nucleus, lobe of cerebellum, lumbar spinal ganglion, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, nucleus of stria terminalis, pituitary gland, putamen, secondary oocyte, superior colliculus, testicle, ventricular zone
RNA expression pattern · 20
TRPC3 → anterior pituitary, buccal mucosa cell, cerebellar vermis, endothelial cell, gastric mucosa, gonad, lateral geniculate nucleus, lateral septal nucleus, lobe of cerebellum, lumbar spinal ganglion, medial dorsal nucleus, medial geniculate nucleus, medial vestibular nucleus, nucleus of stria terminalis, pituitary gland, putamen, secondary oocyte, superior colliculus, testicle, ventricular zone
related to Function · 12
TRPC3 → BDNF, BG, CNS, Conversely, EPSPs, However, Non-specific, The TRPC3, TrkB, TRPC, TRPC3-dependent, While
related to External links · 6
TRPC3 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Modulators · 6
TRPC3 → GSK1702934A, GSK2293017A, GSK417651A, Pyr3 TRPC3, TRPC1, TRPC6
Band · 2
TRPC3 → 3 B|3 17.93 cM, 4q27
Chr. · 2
TRPC3 → Chromosome 3 (mouse), Chromosome 4 (human)
End · 2
TRPC3 → 121,952,060 bp, 36,744,316 bp
Aliases · 1
TRPC3 → TRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp potential human chr band channel gene channels cation chromosome cell calcium protein also transient receptor activation location role known

TRPC3 relationships Subject–Predicate–Object triples

TTTA extracted 107 structured relationships around TRPC3. Examples in this analysis include TRPC3 → Aliases → TRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 3 and TRPC3 → Band → 4q27. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TRPC3AliasesTRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 31.00infobox
TRPC3Band4q271.00infobox
TRPC3Band3 B|3 17.93 cM1.00infobox
TRPC3Bgeebuccal mucosa cell1.00infobox
TRPC3Bgeesecondary oocyte1.00infobox
TRPC3Bgeeendothelial cell1.00infobox
TRPC3Bgeepituitary gland1.00infobox
TRPC3Bgeetesticle1.00infobox
TRPC3Bgeeanterior pituitary1.00infobox
TRPC3Bgeeventricular zone1.00infobox
TRPC3Bgeegastric mucosa1.00infobox
TRPC3Bgeegonad1.00infobox
TRPC3Bgeeputamen1.00infobox
TRPC3Bgeelobe of cerebellum1.00infobox
TRPC3Bgeelumbar spinal ganglion1.00infobox
TRPC3Bgeecerebellar vermis1.00infobox
TRPC3Bgeemedial dorsal nucleus1.00infobox
TRPC3Bgeelateral geniculate nucleus1.00infobox
TRPC3Bgeemedial geniculate nucleus1.00infobox
TRPC3Bgeelateral septal nucleus1.00infobox
TRPC3Bgeemedial vestibular nucleus1.00infobox
TRPC3Bgeenucleus of stria terminalis1.00infobox
TRPC3Bgeesuperior colliculus1.00infobox
TRPC3BioGPSMore reference expression data1.00infobox
TRPC3Chr.Chromosome 4 (human)1.00infobox
TRPC3Chr.Chromosome 3 (mouse)1.00infobox
TRPC3DatabasesNCBI: entry; OMA: entry1.00infobox
TRPC3End121,952,060 bp1.00infobox
TRPC3End36,744,316 bp1.00infobox
TRPC3EnsemblENSG000001387411.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TRPC3 bring nearby vocabulary together. In this analysis, examples include Channel, Potential and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TRPC3
    • Channel
    • Potential
    • Cell
    • Cellular
    • Protein
    • Receptor
    • Transient
    • Gene
    • Channels
    • Human
    • Function
    • Hypertrophy
  • trpc3
    • Channel
    • Potential
    • Cell
    • Cellular
    • Protein
    • Receptor
    • Transient
    • Gene
    • Channels
    • Human
    • Function
    • Hypertrophy
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • End
    • Function
    • Human
    • Mouse
    • Cation
    • Protein
    • Receptor
    • Transient
  • cation channels
    • Activation
    • Function
    • Calcium
    • Location
    • Chromosome
    • Gene
    • Bp
    • Channel
    • Chr
    • External
    • Human
    • Trpc
  • protein
    • Receptor
    • Transient
    • Gene
    • Human
    • Activation
    • End
    • Function
    • Hypertrophy
    • Membrane
    • Mouse
    • Regulation
    • Trpc3
  • function
    • Location
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Human
    • End
    • Hypertrophy
    • Membrane
    • Mouse
    • Regulation
    • Subfamily

Connections between topic areas Semantic bridges

For TRPC3, one of the stronger structural bridges in this analysis connects TRPC3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TRPC3 — Function · splits 12 ⟂ 11
TRPC3 — Modulators · splits 17 ⟂ 6
TRPC3 — Overview · splits 18 ⟂ 5

Map overview Semantic statistics

TRPC3

Nodes23
Edges22
Triples107
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around TRPC3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Modulators & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TRPC3 · EN edition · Analysis: TopicsToTalkAbout

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