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Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around CDKN2B.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CDKN2B shows recurring relationship patterns in the source. For example, CDKN2B → cell cycle, cellular response to extracellular stimulus, cellular response to nutrient, cellular senescence, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytosol, G2/M transition of mitotic cell cycle, megakaryocyte differentiation, mitotic cell cycle checkpoint signaling, negative regulation of cell population proliferation, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of epithelial cell proliferation, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of phosphorylation, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, protein binding, protein kinase binding Another extracted example is CDKN2B → buccal mucosa cell, calvaria, conjunctival fornix, duodenum, endothelial cell of lymphatic vessel, epithelium of stomach, gums, ileum, jejunal mucosa, jejunum, left colon, mucosa of colon, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, oral cavity, rectum, right lung lobe, skin of hip, transitional epithelium of urinary bladder. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene human bp chr band cyclin-dependent kinase inhibitor chromosome location protein p15ink4b tumor suppressor mouse growth ucsc function external also
TTTA extracted 86 structured relationships around CDKN2B. Examples in this analysis include CDKN2B → Aliases → CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B and CDKN2B → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D9S. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CDKN2B | Aliases | CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B | 1.00 | infobox |
| CDKN2B | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D9S | 1.00 | infobox |
| CDKN2B | Band | 9p21.3 | 1.00 | infobox |
| CDKN2B | Band | 4 C4|4 42.15 cM | 1.00 | infobox |
| CDKN2B | Bgee | jejunal mucosa | 1.00 | infobox |
| CDKN2B | Bgee | mucosa of colon | 1.00 | infobox |
| CDKN2B | Bgee | mucosa of sigmoid colon | 1.00 | infobox |
| CDKN2B | Bgee | oral cavity | 1.00 | infobox |
| CDKN2B | Bgee | mucosa of transverse colon | 1.00 | infobox |
| CDKN2B | Bgee | rectum | 1.00 | infobox |
| CDKN2B | Bgee | buccal mucosa cell | 1.00 | infobox |
| CDKN2B | Bgee | duodenum | 1.00 | infobox |
| CDKN2B | Bgee | skin of hip | 1.00 | infobox |
| CDKN2B | Bgee | gums | 1.00 | infobox |
| CDKN2B | Bgee | epithelium of stomach | 1.00 | infobox |
| CDKN2B | Bgee | jejunum | 1.00 | infobox |
| CDKN2B | Bgee | left colon | 1.00 | infobox |
| CDKN2B | Bgee | calvaria | 1.00 | infobox |
| CDKN2B | Bgee | ileum | 1.00 | infobox |
| CDKN2B | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| CDKN2B | Bgee | mucous cell of stomach | 1.00 | infobox |
| CDKN2B | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| CDKN2B | Bgee | right lung lobe | 1.00 | infobox |
| CDKN2B | Bgee | conjunctival fornix | 1.00 | infobox |
| CDKN2B | BioGPS | More reference expression data | 1.00 | infobox |
| CDKN2B | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| CDKN2B | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| CDKN2B | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CDKN2B | End | 22,009,305 bp | 1.00 | infobox |
| CDKN2B | End | 89,229,276 bp | 1.00 | infobox |
The concept neighborhoods around CDKN2B bring nearby vocabulary together. In this analysis, examples include Gene, Cyclin-dependent and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CDKN2B, one of the stronger structural bridges in this analysis connects CDKN2B with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CDKN2B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CDKN2B · EN edition · Analysis: TopicsToTalkAbout