SHANK1

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Clinical significance

Scaffold protein Autism spectrum disorder Schizophrenia Intellectual disability Chromosome 19

8 related topics

Interactions

Interact ARHGEF7 BAIAP2 DNM2 SPTAN1

6 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
Band: 19q13.33 · 7|7 B3
Bgee: anterior cingulate cortex · right frontal lobe · prefrontal cortex · amygdala · right hemisphere of cerebellum
BioGPS: n/a
Chr.: Chromosome 19 (human) · Chromosome 7 (mouse)
Databases: NCBI: entry; OMA: entry

Topics to explore

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Overview

Interactions

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Nodes20

Edges19

Triples131

Avg. degree1.9

Density0.1

Components1

How this topic connects Entity context

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SHANK1

Top relations

Gene ontology · 56

SHANK1 → adult behavior, ankyrin repeat binding, associative learning, brain morphogenesis, cell differentiation, cell junction, cytoplasm, cytosol, dendrite, dendritic spine, dendritic spine morphogenesis, determination of affect, excitatory synapse, glutamatergic synapse, habituation, identical protein binding, intracellular anatomical structure, ionotropic glutamate receptor binding, ionotropic glutamate receptor complex, long-term memory

Bgee · 17

SHANK1 → amygdala, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dorsolateral prefrontal cortex, hippocampus proper, lateral geniculate nucleus, medial dorsal nucleus, middle temporal gyrus, piriform cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, temporal lobe

RNA expression pattern · 17

related to Clinical significance · 13

SHANK1 → ASD, Canadian, European, In, Mutations, Researchers, Sato, SHANK, SHANK2, SHANK3, The, These, This

related to Interactions · 4

SHANK1 → ARHGEF7, BAIAP2, DNM2, SPTAN1

Band · 2

SHANK1 → 19q13.33, 7|7 B3

Chr. · 2

SHANK1 → Chromosome 19 (human), Chromosome 7 (mouse)

End · 2

SHANK1 → 44,009,996 bp, 50,719,802 bp

Aliases · 1

SHANK1 → SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1

BioGPS · 1

SHANK1 → n/a

Important terminology Word statistics

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Important terminology

gene asd deletion chromosome bp human individuals 19 chr band mutations protein also males found individual sh3 ankyrin repeat location

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SHANK1	Aliases	SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1	1.00	infobox
SHANK1	Band	19q13.33	1.00	infobox
SHANK1	Band	7\|7 B3	1.00	infobox
SHANK1	Bgee	anterior cingulate cortex	1.00	infobox
SHANK1	Bgee	right frontal lobe	1.00	infobox
SHANK1	Bgee	prefrontal cortex	1.00	infobox
SHANK1	Bgee	amygdala	1.00	infobox
SHANK1	Bgee	right hemisphere of cerebellum	1.00	infobox
SHANK1	Bgee	primary visual cortex	1.00	infobox
SHANK1	Bgee	dorsolateral prefrontal cortex	1.00	infobox
SHANK1	Bgee	Brodmann area 9	1.00	infobox
SHANK1	Bgee	hippocampus proper	1.00	infobox
SHANK1	Bgee	middle temporal gyrus	1.00	infobox
SHANK1	Bgee	primary motor cortex	1.00	infobox
SHANK1	Bgee	temporal lobe	1.00	infobox
SHANK1	Bgee	subiculum	1.00	infobox
SHANK1	Bgee	cingulate gyrus	1.00	infobox
SHANK1	Bgee	lateral geniculate nucleus	1.00	infobox
SHANK1	Bgee	piriform cortex	1.00	infobox
SHANK1	Bgee	medial dorsal nucleus	1.00	infobox
SHANK1	BioGPS	n/a	1.00	infobox
SHANK1	Chr.	Chromosome 19 (human)	1.00	infobox
SHANK1	Chr.	Chromosome 7 (mouse)	1.00	infobox
SHANK1	Databases	NCBI: entry; OMA: entry	1.00	infobox
SHANK1	End	50,719,802 bp	1.00	infobox
SHANK1	End	44,009,996 bp	1.00	infobox
SHANK1	Ensembl	ENSG00000161681	1.00	infobox
SHANK1	Entrez	50944	1.00	infobox
SHANK1	External IDs	OMIM: 604999; MGI: 3613677; GeneCards: SHANK1	1.00	infobox
SHANK1	Gene location (Human)	Gene location (Human)Chr.Chromosome 19 (human)Band19q13.33Start50,659,255 bpEnd50,719,802 bp	1.00	infobox

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