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SHANK1: Clinical significance, Interactions & Overview

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.

Language: English [EN]
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SHANK1 topic overview

The analysis highlights Clinical significance, Interactions and Overview as prominent areas in the source structure around SHANK1.

Related topics
16
Source areas
3
Connected nodes
19
Extracted relationships
131
Concept neighborhoods
10
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 8 topics
Interactions · 6 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
Band
19q13.33 · 7|7 B3
Bgee
anterior cingulate cortex · right frontal lobe · prefrontal cortex · amygdala · right hemisphere of cerebellum
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SHANK1 connects Entity context

The extracted context around SHANK1 shows recurring relationship patterns in the source. For example, SHANK1 → adult behavior, ankyrin repeat binding, associative learning, brain morphogenesis, cell differentiation, cell junction, cytoplasm, cytosol, dendrite, dendritic spine, dendritic spine morphogenesis, determination of affect, excitatory synapse, glutamatergic synapse, habituation, identical protein binding, intracellular anatomical structure, ionotropic glutamate receptor binding, ionotropic glutamate receptor complex, long-term memory Another extracted example is SHANK1 → amygdala, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dorsolateral prefrontal cortex, hippocampus proper, lateral geniculate nucleus, medial dorsal nucleus, middle temporal gyrus, piriform cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, temporal lobe. Use these groups to spot repeated connection types before inspecting the individual relationships.

SHANK1

Top relations

Gene ontology · 56
SHANK1 → adult behavior, ankyrin repeat binding, associative learning, brain morphogenesis, cell differentiation, cell junction, cytoplasm, cytosol, dendrite, dendritic spine, dendritic spine morphogenesis, determination of affect, excitatory synapse, glutamatergic synapse, habituation, identical protein binding, intracellular anatomical structure, ionotropic glutamate receptor binding, ionotropic glutamate receptor complex, long-term memory
Bgee · 17
SHANK1 → amygdala, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dorsolateral prefrontal cortex, hippocampus proper, lateral geniculate nucleus, medial dorsal nucleus, middle temporal gyrus, piriform cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, temporal lobe
RNA expression pattern · 17
SHANK1 → amygdala, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dorsolateral prefrontal cortex, hippocampus proper, lateral geniculate nucleus, medial dorsal nucleus, middle temporal gyrus, piriform cortex, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, subiculum, temporal lobe
related to Clinical significance · 13
SHANK1 → ASD, Canadian, European, In, Mutations, Researchers, Sato, SHANK, SHANK2, SHANK3, The, These, This
related to Interactions · 4
SHANK1 → ARHGEF7, BAIAP2, DNM2, SPTAN1
Band · 2
SHANK1 → 19q13.33, 7|7 B3
Chr. · 2
SHANK1 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
SHANK1 → 44,009,996 bp, 50,719,802 bp
Aliases · 1
SHANK1 → SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
BioGPS · 1
SHANK1 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene asd deletion chromosome bp human individuals 19 chr band mutations protein also males found individual sh3 ankyrin repeat location

SHANK1 relationships Subject–Predicate–Object triples

TTTA extracted 131 structured relationships around SHANK1. Examples in this analysis include SHANK1 → Aliases → SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1 and SHANK1 → Band → 19q13.33. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SHANK1AliasesSHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 11.00infobox
SHANK1Band19q13.331.00infobox
SHANK1Band7|7 B31.00infobox
SHANK1Bgeeanterior cingulate cortex1.00infobox
SHANK1Bgeeright frontal lobe1.00infobox
SHANK1Bgeeprefrontal cortex1.00infobox
SHANK1Bgeeamygdala1.00infobox
SHANK1Bgeeright hemisphere of cerebellum1.00infobox
SHANK1Bgeeprimary visual cortex1.00infobox
SHANK1Bgeedorsolateral prefrontal cortex1.00infobox
SHANK1BgeeBrodmann area 91.00infobox
SHANK1Bgeehippocampus proper1.00infobox
SHANK1Bgeemiddle temporal gyrus1.00infobox
SHANK1Bgeeprimary motor cortex1.00infobox
SHANK1Bgeetemporal lobe1.00infobox
SHANK1Bgeesubiculum1.00infobox
SHANK1Bgeecingulate gyrus1.00infobox
SHANK1Bgeelateral geniculate nucleus1.00infobox
SHANK1Bgeepiriform cortex1.00infobox
SHANK1Bgeemedial dorsal nucleus1.00infobox
SHANK1BioGPSn/a1.00infobox
SHANK1Chr.Chromosome 19 (human)1.00infobox
SHANK1Chr.Chromosome 7 (mouse)1.00infobox
SHANK1DatabasesNCBI: entry; OMA: entry1.00infobox
SHANK1End50,719,802 bp1.00infobox
SHANK1End44,009,996 bp1.00infobox
SHANK1EnsemblENSG000001616811.00infobox
SHANK1Entrez509441.00infobox
SHANK1External IDsOMIM: 604999; MGI: 3613677; GeneCards: SHANK11.00infobox
SHANK1Gene location (Human)Gene location (Human)Chr.Chromosome 19 (human)Band19q13.33Start50,659,255 bpEnd50,719,802 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SHANK1 bring nearby vocabulary together. In this analysis, examples include Deletion, Male and Mutation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Shank1
    • Deletion
    • Chromosome
    • Asd
    • Males
    • Location
    • Repeat
    • Sh3
    • Mutation
    • Bp
    • Chr
    • Found
  • chromosome 19
    • Bp
    • Human
    • Location
    • Band
    • Mouse
    • Gene
    • Repeat
    • Sh3
    • Protein
    • Shank1
    • Domains
    • Multiple
  • chromosome 11
    • Bp
    • Human
    • Location
    • Band
    • Mouse
    • Gene
    • Repeat
    • Sh3
    • Protein
    • Shank1
    • Domains
    • Multiple
  • protein
    • Brain
    • Repeat
    • Sh3
    • Shank1
    • Chromosome
    • Mouse
    • Gene
    • Location
    • Band
    • Male
    • Mutation
    • Study
  • scaffold protein
    • Brain
    • Repeat
    • Sh3
    • Shank1
    • Chromosome
    • Mouse
    • Gene
    • Location
    • Band
    • Male
    • Mutation
    • Study
  • SHANK1
    • Deletion
    • Male
    • Mutation
    • Individual
    • Inherited
    • Present
    • Shank2
    • Shank3
    • Unrelated
    • Study
    • Found
    • Order
  • shank1
    • Deletion
    • Male
    • Mutation
    • Individual
    • Inherited
    • Present
    • Shank2
    • Shank3
    • Unrelated
    • Study
    • Found
    • Order
  • autism spectrum disorder
    • Disorders
    • Brain
    • Including
    • Group
    • Study
    • Asd
    • Human
    • Individual
    • Also
    • Mutations
    • Gene
    • Shank1

Connections between topic areas Semantic bridges

For SHANK1, one of the stronger structural bridges in this analysis connects SHANK1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SHANK1Clinical significance · splits 11 ⟂ 9
SHANK1Interactions · splits 13 ⟂ 7
SHANK1Overview · splits 17 ⟂ 3

Map overview Semantic statistics

SHANK1

Nodes20
Edges19
Triples131
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around SHANK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SHANK1 · EN edition · Analysis: TopicsToTalkAbout

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