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SNCAIP: Function, Ubiquitination & Structure

Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene. SNCAIP stands for "synuclein, alpha interacting protein".

Language: English [EN]
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SNCAIP topic overview

The analysis highlights Function, Ubiquitination and Structure as prominent areas in the source structure around SNCAIP.

Related topics
34
Source areas
6
Connected nodes
40
Extracted relationships
98
Concept neighborhoods
19
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Ubiquitination · 11 topics
Structure · 7 topics
Interactions · 2 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SNCAIP, SYPH1, Sph1, synuclein alpha interacting protein
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KES
Band
5q23.2 · 18|18 D1
Bgee
ventricular zone · ganglionic eminence · germinal epithelium · periodontal fiber · endometrium
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Ubiquitination

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SNCAIP connects Entity context

The extracted context around SNCAIP shows recurring relationship patterns in the source. For example, SNCAIP → bronchial epithelial cell, endometrium, epithelium of bronchus, external carotid artery, ganglionic eminence, genital tubercle, germinal epithelium, internal carotid artery, lumbar subsegment of spinal cord, myometrium, neural tube, parietal pleura, periodontal fiber, renal corpuscle, Rostral migratory stream, saccule, stromal cell of endometrium, ventricular zone Another extracted example is SNCAIP → cell death, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, dopamine metabolic process, identical protein binding, nucleoplasm, presynaptic membrane, protein binding, regulation of inclusion body assembly, regulation of neurotransmitter secretion, soma, synaptic vesicle, ubiquitin protein ligase binding. Use these groups to spot repeated connection types before inspecting the individual relationships.

SNCAIP

Top relations

Bgee · 18
SNCAIP → bronchial epithelial cell, endometrium, epithelium of bronchus, external carotid artery, ganglionic eminence, genital tubercle, germinal epithelium, internal carotid artery, lumbar subsegment of spinal cord, myometrium, neural tube, parietal pleura, periodontal fiber, renal corpuscle, Rostral migratory stream, saccule, stromal cell of endometrium, ventricular zone
RNA expression pattern · 18
SNCAIP → bronchial epithelial cell, endometrium, epithelium of bronchus, external carotid artery, ganglionic eminence, genital tubercle, germinal epithelium, internal carotid artery, lumbar subsegment of spinal cord, myometrium, neural tube, parietal pleura, periodontal fiber, renal corpuscle, Rostral migratory stream, saccule, stromal cell of endometrium, ventricular zone
Gene ontology · 14
SNCAIP → cell death, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, dopamine metabolic process, identical protein binding, nucleoplasm, presynaptic membrane, protein binding, regulation of inclusion body assembly, regulation of neurotransmitter secretion, soma, synaptic vesicle, ubiquitin protein ligase binding
related to Clinical significance · 12
SNCAIP → Beyond Parkinson's, Clinically, Genetic, It, Lewy, Parkinson's, PD, RNA, This, Thus, Transcriptomic, While
related to Structure · 7
SNCAIP → Lewy, N-terminal, SNCA, Structurally, The, The SNCAIP, These
related to Function · 4
SNCAIP → Experimental, It, Synphilin-1, Synphilin-1's
Band · 2
SNCAIP → 18|18 D1, 5q23.2
Chr. · 2
SNCAIP → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
SNCAIP → 122,464,219 bp, 53,049,007 bp
Aliases · 1
SNCAIP → SNCAIP, SYPH1, Sph1, synuclein alpha interacting protein

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

synphilin-1 protein gene bp chr human band α-synuclein bodies alpha-synuclein inclusions lewy chromosome synaptic cytoplasmic function neuronal disease formation binding

SNCAIP relationships Subject–Predicate–Object triples

TTTA extracted 98 structured relationships around SNCAIP. Examples in this analysis include SNCAIP → Aliases → SNCAIP, SYPH1, Sph1, synuclein alpha interacting protein and SNCAIP → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KES. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SNCAIPAliasesSNCAIP, SYPH1, Sph1, synuclein alpha interacting protein1.00infobox
SNCAIPAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KES1.00infobox
SNCAIPBand5q23.21.00infobox
SNCAIPBand18|18 D11.00infobox
SNCAIPBgeeventricular zone1.00infobox
SNCAIPBgeeganglionic eminence1.00infobox
SNCAIPBgeegerminal epithelium1.00infobox
SNCAIPBgeeperiodontal fiber1.00infobox
SNCAIPBgeeendometrium1.00infobox
SNCAIPBgeeparietal pleura1.00infobox
SNCAIPBgeestromal cell of endometrium1.00infobox
SNCAIPBgeeepithelium of bronchus1.00infobox
SNCAIPBgeebronchial epithelial cell1.00infobox
SNCAIPBgeemyometrium1.00infobox
SNCAIPBgeegenital tubercle1.00infobox
SNCAIPBgeelumbar subsegment of spinal cord1.00infobox
SNCAIPBgeeexternal carotid artery1.00infobox
SNCAIPBgeesaccule1.00infobox
SNCAIPBgeeinternal carotid artery1.00infobox
SNCAIPBgeeneural tube1.00infobox
SNCAIPBgeeRostral migratory stream1.00infobox
SNCAIPBgeerenal corpuscle1.00infobox
SNCAIPBioGPSMore reference expression data1.00infobox
SNCAIPChr.Chromosome 5 (human)1.00infobox
SNCAIPChr.Chromosome 18 (mouse)1.00infobox
SNCAIPDatabasesNCBI: entry; OMA: entry1.00infobox
SNCAIPEnd122,464,219 bp1.00infobox
SNCAIPEnd53,049,007 bp1.00infobox
SNCAIPEnsemblENSG000000646921.00infobox
SNCAIPEntrez96271.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SNCAIP bring nearby vocabulary together. In this analysis, examples include Gene, Function and Related. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SNCAIP
    • Gene
    • Function
    • Related
    • Alpha
    • Interacting
    • Synuclein
    • Expression
    • Ligase
    • Location
    • Chromosome
    • Cytoplasmic
    • Human
  • sncaip
    • Gene
    • Function
    • Related
    • Alpha
    • Interacting
    • Synuclein
    • Expression
    • Ligase
    • Location
    • Chromosome
    • Cytoplasmic
    • Human
  • protein
    • Sncaip
    • Function
    • Synphilin-1
    • Cytoplasmic
    • Neuronal
    • Synaptic
    • Gene
    • Alpha
    • Interacting
    • Synuclein
    • Binding
    • Cellular
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Sncaip
    • Mouse
    • Function
    • Band
    • Protein
    • Alpha
    • Interacting
  • synaptic vesicle trafficking
    • Synaptic
    • Vesicle
    • Binding
    • Alpha-synuclein
    • Localized
    • Mouse
    • Synphilin-1
    • Cellular
    • Expression
    • Function
    • Implicated
    • Ligase
  • scaffold protein
    • Sncaip
    • Function
    • Synphilin-1
    • Cytoplasmic
    • Neuronal
    • Synaptic
    • Gene
    • Alpha
    • Interacting
    • Synuclein
    • Binding
    • Cellular
  • protein degradation
    • Sncaip
    • Function
    • Synphilin-1
    • Cytoplasmic
    • Neuronal
    • Synaptic
    • Gene
    • Alpha
    • Interacting
    • Synuclein
    • Binding
    • Cellular
  • function
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Neuronal
    • Sncaip
    • Synaptic
    • Gene
    • Protein
    • Interacting
    • Mouse

Connections between topic areas Semantic bridges

For SNCAIP, one of the stronger structural bridges in this analysis connects SNCAIP with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SNCAIPFunction · splits 29 ⟂ 12
SNCAIPUbiquitination · splits 29 ⟂ 12
SNCAIPStructure · splits 33 ⟂ 8
SNCAIPOverview · splits 38 ⟂ 3
SNCAIPInteractions · splits 38 ⟂ 3

Map overview Semantic statistics

SNCAIP

Nodes41
Edges40
Triples98
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around SNCAIP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Ubiquitination & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SNCAIP · EN edition · Analysis: TopicsToTalkAbout

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