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Notch signaling pathway

The Notch signaling pathway is a highly conserved cell signaling system present in most animals. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a…

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Overview

Discovery

Mechanism

Function

Role in embryogenesis

Role in central nervous system development and function

Role in cardiovascular development

Role in endocrine development

Role in cell cycle control

Role in cancer

Role in Long-lived bat

Notch inhibitors

Mathematical modeling

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Notch signaling pathway

Nodes166
Edges165
Triples88
Avg. degree1.99
Density0.012048
Components1

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Notch signaling pathway

Top relations

related to Role in somitogenesis · 15
Notch signaling pathway → Delta1, Dll1, Dll3, During, Experiments, Further, Hes7, In, Lfng, Notch, Notch1, Several, Similarly, These, This
related to Neuron cell differentiation · 12
Notch signaling pathway → Activation, Conversely, Hes3, In, Modulators, Notch, NPC, NPCs, Numb, STAT3, STAT3-Ser/Hes3 Signaling Axis, The Notch
related to External links · 9
Notch signaling pathway → Diagram, Drosophila Archived, Homo, Medicine Medical Subject Headings, MeSH, National Library, Notch, Receptors, Wayback MachineNotch
related to Role in central nervous system development and function · 9
Notch signaling pathway → CNS, Drosophila, Early, Epidermal, For, In, Notch, NPC, The Notch
related to Angiogenesis · 8
Notch signaling pathway → Activation, Delta-like, Dll4, Endothelial, Notch, VEGF, VEGF3, Zebrafish
related to Pancreatic development · 7
Notch signaling pathway → Evidence, Fibroblast, Here, Lateral, Notch, One, The
related to Bone development · 5
Notch signaling pathway → Early, Notch, Notch1, Overall, Overexpression
related to Function · 5
Notch signaling pathway → AblRegulation, Hedgehog, Notch, SclT, The Notch
related to Intestinal development · 5
Notch signaling pathway → Hes1, Mutations, Notch, The, Transcriptional
related to Liver cancer · 4
Notch signaling pathway → AXIN1, In, Notch, Thus

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Important terminology

notch signaling cell cells development pathway role expression differentiation ligand drosophila also ligands intracellular domain model protein notch1 extracellular ventricular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Notch signaling pathwayis ahighly conserved cell signaling system present in most animals0.90text
Notch signaling pathwayis acritical component of cardiovascular formation and morphogenesis in both development and disease0.90text
ribosomeinstance ofNotch activity cooperates with additional oncogenic lesions such as c-MYC to activate anabolic pathways0.80text
protein biosynthesis thereby promoting leukemia cell growth.Urothelial bladder cancerLoss of Notch activity is a driving event in urothelial cancerinstance ofNotch activity cooperates with additional oncogenic lesions such as c-MYC to activate anabolic pathways0.80text
protein biosynthesis thereby promoting leukemia cell growthinstance ofNotch activity cooperates with additional oncogenic lesions such as c-MYC to activate anabolic pathways0.80text
Notch to this trait is only beginning to be exploredinstance ofyet the contribution of modified intercellular signaling pathways0.80text
Notch signaling pathwayrelated to AngiogenesisEndothelial0.60section
Notch signaling pathwayrelated to AngiogenesisNotch0.60section
Notch signaling pathwayrelated to AngiogenesisActivation0.60section
Notch signaling pathwayrelated to AngiogenesisDelta-like0.60section
Notch signaling pathwayrelated to AngiogenesisDll40.60section
Notch signaling pathwayrelated to AngiogenesisVEGF0.60section

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