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BAG3

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy.

Interactions, Function & Clinical significance

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Interactions

27 related topics

Function

10 related topics

Clinical significance

7 related topics

Overview

3 related topics

Key facts & relationships

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Aliases
BAG3, BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UK5
Band
10q26.11 · 7|7 F3
Bgee
gastrocnemius muscle · Skeletal muscle tissue of rectus abdominis · body of tongue · glutes · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 7 (mouse)

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Overview

Function

Clinical significance

Interactions

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Map overview Semantic statistics

BAG3

Nodes52
Edges51
Triples125
Avg. degree1.96
Density0.038462
Components1

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BAG3

Top relations

Gene ontology · 27
BAG3 → adenyl-nucleotide exchange factor activity, apoptotic process, brain development, cadherin binding, cellular response to heat, cellular response to mechanical stimulus, chaperone binding, cytoplasm, cytosol, extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of apoptotic process, negative regulation of striated muscle cell apoptotic process, negative regulation of transcription from RNA polymerase II promoter in response to stress, neuron projection, nucleus, plasma membrane, positive regulation of protein export from nucleus, positive regulation of protein import into nucleus, protein binding
Bgee · 19
BAG3 → ankle, body of tongue, cardiac muscle tissue of left ventricle, digastric muscle, extraocular muscle, gastrocnemius muscle, gastrula, glutes, interventricular septum, muscle of thigh, plantaris muscle, quadriceps femoris muscle, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle, vena cava
RNA expression pattern · 19
BAG3 → ankle, body of tongue, cardiac muscle tissue of left ventricle, digastric muscle, extraocular muscle, gastrocnemius muscle, gastrula, glutes, interventricular septum, muscle of thigh, plantaris muscle, quadriceps femoris muscle, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle, vena cava
related to Function · 15
BAG3 → All, ATPase, BAG, BAG1, BAG2, C-terminal, Hip-1, Hip-repressible, Hsc70, Hsc70 ATPase, Hsc70/Hsp70 ATPase, N-terminal, The, The BAG, WW
related to Clinical significance · 12
BAG3 → Alzheimer's, BAG, BAG1, Hsc70, HSPB7, HspB8, In, It, Moreover, Stops, That BAG3, This
related to External links · 9
BAG3 → GeneReviews/NIH/NCBI/UW, Mouse BAG, Myofibrillar MyopathyHuman BAG3, Overview, PDB, PDBe-KB, Q9JLV1, UCSC Genome Browser, UniProt
Band · 2
BAG3 → 10q26.11, 7|7 F3
Chr. · 2
BAG3 → Chromosome 10 (human), Chromosome 7 (mouse)
End · 2
BAG3 → 119,677,819 bp, 128,148,705 bp
Aliases · 1
BAG3 → BAG3, BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 3

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Important terminology

gene bag bp human protein chr band domain molecular chromosome 10 chaperone location hsc70 mouse proteins atpase muscle activity mechanical

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BAG3AliasesBAG3, BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 31.00infobox
BAG3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1UK51.00infobox
BAG3Band10q26.111.00infobox
BAG3Band7|7 F31.00infobox
BAG3Bgeegastrocnemius muscle1.00infobox
BAG3BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
BAG3Bgeebody of tongue1.00infobox
BAG3Bgeeglutes1.00infobox
BAG3Bgeemuscle of thigh1.00infobox
BAG3Bgeequadriceps femoris muscle1.00infobox
BAG3Bgeevastus lateralis muscle1.00infobox
BAG3Bgeetibialis anterior muscle1.00infobox
BAG3Bgeetriceps brachii muscle1.00infobox
BAG3Bgeevena cava1.00infobox
BAG3Bgeecardiac muscle tissue of left ventricle1.00infobox
BAG3Bgeegastrula1.00infobox
BAG3Bgeeankle1.00infobox
BAG3Bgeeplantaris muscle1.00infobox
BAG3Bgeeinterventricular septum1.00infobox
BAG3Bgeeright ventricle1.00infobox
BAG3Bgeesoleus muscle1.00infobox
BAG3Bgeeextraocular muscle1.00infobox
BAG3Bgeedigastric muscle1.00infobox
BAG3BioGPSMore reference expression data1.00infobox
BAG3Chr.Chromosome 10 (human)1.00infobox
BAG3Chr.Chromosome 7 (mouse)1.00infobox
BAG3DatabasesNCBI: entry; OMA: entry1.00infobox
BAG3End119,677,819 bp1.00infobox
BAG3End128,148,705 bp1.00infobox
BAG3EnsemblENSG000001519291.00infobox

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