Platelet-derived growth factor receptor A

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Platelet-derived growth factor receptor A. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Clinical significance

Gain-of-function Histone H3 Polycomb repressive complex 2 Methyltransferase Methylation

12 related topics

Overview

Receptor Gene Isoforms Platelet-derived growth factors Cell signaling

47 related topics

Modes of activation

Dimer PDGF-A PDGF-B PDGF-C Phosphorylates itself

9 related topics

Interactions

Interact CRK Caveolin 1 Cbl gene PDGFC

8 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1: ↗
Aliases: PDGFRA, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor α, PDGFRα, CD140a, PDGFR 2, RHEPDGFRA
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GQ5
Band: 4q12 · 5 C3.3|5 39.55 cM
Bgee: tibia · decidua · synovial joint · pericardium · lower lobe of lung
BioGPS: More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Receptor Receptor (biochemistry)
Gene
Isoforms Isoform
Platelet-derived growth factors Platelet-derived growth factor
Cell signaling
Cellular growth Cell growth
Differentiation Cellular differentiation
Embryonic development
Hematologic
Somatic mutations Mutation
Neoplasms
Clonal hypereosinophilia
Gastrointestinal stromal tumors Gastrointestinal stromal tumor
Hematopoietic stem cells Hematopoietic stem cell
Hematological malignancy Tumors of the hematopoietic and lymphoid tissues
Fused genes Fusion gene
Chimeric proteins Fusion protein
Tyrosine kinase
Leukemias Leukemia
Lymphomas Lymphoma
Myelodysplastic syndromes
Hypereosinophilia
FIP1L1-PDGFRA fusion genes FIP1L1
LNX LNX1
Eosinophilia
Chronic eosinophilic leukemia
Myeloproliferative neoplasm
Myeloblastic leukemia
T-lymphoblastic leukemia/lymphoma
Myeloid sarcoma

Overall structure

Modes of activation

Dimer Protein dimer
PDGF-A
PDGF-B
PDGF-C
Phosphorylates itself Autophosphorylation
Intracellular signaling pathways Intracellular signaling pathway
Constitutive activation
Reactive oxygen species
Src family kinases Src family kinase

Role in physiology/pathology

Clinical significance

Interactions

Interact Protein-protein interaction
CRK CRK (gene)
Caveolin 1
Cbl gene
PDGFC
PDGFR-β
PLCG1
Sodium-hydrogen antiporter 3 regulator 1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Platelet-derived growth factor receptor A

Nodes91

Edges90

Triples163

Avg. degree1.98

Density0.021978

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Platelet-derived growth factor receptor A

Top relations

Gene ontology · 92

Platelet-derived growth factor receptor A → adrenal gland development, anatomical structure morphogenesis, animal organ morphogenesis, ATP binding, cardiac myofibril assembly, cell activation, cell chemotaxis, cell junction, cell migration, cell projection, cell surface, cellular response to amino acid stimulus, cellular response to reactive oxygen species, chemotaxis, cilium, cytoplasm, embryonic cranial skeleton morphogenesis, embryonic digestive tract morphogenesis, embryonic skeletal system morphogenesis, estrogen metabolic process

Bgee · 20

Platelet-derived growth factor receptor A → ankle, caput epididymis, decidua, dermis, efferent ductule, epithelium of lens, gastrula, Gonadal ridge, left ovary, lower lobe of lung, molar, parietal pleura, pericardium, pylorus, stroma of kidney, stromal cell of endometrium, synovial joint, tibia, vas deferens, vestibular sensory epithelium

RNA expression pattern · 20

Band · 2

Platelet-derived growth factor receptor A → 4q12, 5 C3.3|5 39.55 cM

Chr. · 2

Platelet-derived growth factor receptor A → Chromosome 4 (human), Chromosome 5 (mouse)

End · 2

Platelet-derived growth factor receptor A → 54,298,245 bp, 75,358,876 bp

2.7.10.1 · 1

Platelet-derived growth factor receptor A → ↗

Aliases · 1

Platelet-derived growth factor receptor A → PDGFRA, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor α, PDGFRα, CD140a, PDGFR 2, RHEPDGFRA

Available structures · 1

Platelet-derived growth factor receptor A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GQ5

BioGPS · 1

Platelet-derived growth factor receptor A → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pdgfra gene mutations receptor pdgfrα tumors kinase gist human growth chromosome tyrosine protein platelet-derived bp also development cell chr band

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Platelet-derived growth factor receptor A	2.7.10.1	↗	1.00	infobox
Platelet-derived growth factor receptor A	Aliases	PDGFRA, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor α, PDGFRα, CD140a, PDGFR 2, RHEPDGFRA	1.00	infobox
Platelet-derived growth factor receptor A	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GQ5	1.00	infobox
Platelet-derived growth factor receptor A	Band	4q12	1.00	infobox
Platelet-derived growth factor receptor A	Band	5 C3.3\|5 39.55 cM	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	tibia	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	decidua	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	synovial joint	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	pericardium	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	lower lobe of lung	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	pylorus	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	stromal cell of endometrium	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	parietal pleura	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	caput epididymis	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	left ovary	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	vas deferens	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	gastrula	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	efferent ductule	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	stroma of kidney	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	Gonadal ridge	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	vestibular sensory epithelium	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	dermis	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	molar	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	epithelium of lens	1.00	infobox
Platelet-derived growth factor receptor A	Bgee	ankle	1.00	infobox
Platelet-derived growth factor receptor A	BioGPS	More reference expression data	1.00	infobox
Platelet-derived growth factor receptor A	Chr.	Chromosome 4 (human)	1.00	infobox
Platelet-derived growth factor receptor A	Chr.	Chromosome 5 (mouse)	1.00	infobox
Platelet-derived growth factor receptor A	Databases	NCBI: entry; OMA: entry	1.00	infobox
Platelet-derived growth factor receptor A	End	54,298,245 bp	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3