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FOXP3

FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of…

Pathophysiology, Physiology & Role in cancer

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Aliases
FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QRF, 4WK8
Band
Xp11.23 · X A1.1|X 3.41 cM
Bgee
gonad · testicle · tendon of biceps brachii · lymph node · cecum
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Overview

Structure

Identification

Physiology

Pathophysiology

Role in cancer

Autoimmune

Advanced semantic analysis

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Map overview Semantic statistics

FOXP3

Nodes89
Edges88
Triples224
Avg. degree1.98
Density0.022472
Components1

How this topic connects Entity context

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FOXP3

Top relations

Gene ontology · 81
FOXP3 → anatomical structure morphogenesis, B cell homeostasis, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment, chromatin remodeling, cytokine production, cytoplasm, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, histone acetyltransferase binding, histone deacetylase binding, intracellular anatomical structure, metal ion binding, myeloid cell homeostasis, negative regulation of activated T cell proliferation, negative regulation of cell population proliferation, negative regulation of chronic inflammatory response, negative regulation of CREB transcription factor activity, negative regulation of DNA-binding transcription factor activity
related to Pathophysiology · 22
FOXP3 → CD4, Conversely, CTLA-4, DNA-binding, Enteropathy, For, Histologic, Immunodysregulation, In, IPEX, Many, Polyendocrinopathy, Scurfy, SLE, T-cell, T-lymphocytes, TGF-β, The, The FOXP3, These
Bgee · 20
FOXP3 → appendix, blastocyst, blood, cecum, dentate gyrus of hippocampal formation granule cell, embryo, gallbladder, gonad, granulocyte, lymph node, male urethra, meninges, neural layer of retina, pharynx, tail of embryo, tendon of biceps brachii, testicle, thymus, tonsil, urethra
RNA expression pattern · 20
FOXP3 → appendix, blastocyst, blood, cecum, dentate gyrus of hippocampal formation granule cell, embryo, gallbladder, gonad, granulocyte, lymph node, male urethra, meninges, neural layer of retina, pharynx, tail of embryo, tendon of biceps brachii, testicle, thymus, tonsil, urethra
related to Autoimmune · 11
FOXP3 → ADP, Another, ATP, CD39, For, It, Mutations, Regulated, SLE, These, Treg
related to Physiology · 6
FOXP3 → CD25, CD45RB, Human, In, The, Tregs
related to External links · 5
FOXP3 → GeneReviews/NIH/NCBI/UW, IPEX SyndromeFOXP3, Medicine Medical Subject Headings, MeSH, National Library
related to Role in cancer · 5
FOXP3 → Down-regulation, Expression, FOXP3's, However, In
is a · 4
FOXP3 → major transcription factor controlling T-regulatory cells, potential tumour suppressor gene, pro- or anti-tumourigeneic molecule in these tumours, recruiter of other anti-tumor enzymes such as CD39 and CD8
related to Structure · 4
FOXP3 → By, Exon-intron, The, Xp11

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Important terminology

cells regulatory cancer cell human transcription gene immune autoimmune treg also protein system bp function forkhead disease ipex expression activity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FOXP3AliasesFOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P31.00infobox
FOXP3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QRF, 4WK81.00infobox
FOXP3BandXp11.231.00infobox
FOXP3BandX A1.1|X 3.41 cM1.00infobox
FOXP3Bgeegonad1.00infobox
FOXP3Bgeetesticle1.00infobox
FOXP3Bgeetendon of biceps brachii1.00infobox
FOXP3Bgeelymph node1.00infobox
FOXP3Bgeececum1.00infobox
FOXP3Bgeeappendix1.00infobox
FOXP3Bgeeblood1.00infobox
FOXP3Bgeetonsil1.00infobox
FOXP3Bgeegallbladder1.00infobox
FOXP3Bgeegranulocyte1.00infobox
FOXP3Bgeeurethra1.00infobox
FOXP3Bgeemale urethra1.00infobox
FOXP3Bgeeblastocyst1.00infobox
FOXP3Bgeeembryo1.00infobox
FOXP3Bgeepharynx1.00infobox
FOXP3Bgeethymus1.00infobox
FOXP3Bgeemeninges1.00infobox
FOXP3Bgeetail of embryo1.00infobox
FOXP3Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
FOXP3Bgeeneural layer of retina1.00infobox
FOXP3BioGPSMore reference expression data1.00infobox
FOXP3Chr.X chromosome (human)1.00infobox
FOXP3Chr.X chromosome (mouse)1.00infobox
FOXP3DatabasesNCBI: entry; OMA: entry1.00infobox
FOXP3End49,270,477 bp1.00infobox
FOXP3End7,461,484 bp1.00infobox

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