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LRRK2: Function, Clinical significance & Overview

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a large, multifunctional kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene…

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LRRK2 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around LRRK2.

Related topics
23
Source areas
3
Connected nodes
26
Extracted relationships
258
Concept neighborhoods
16
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Clinical significance · 6 topics
Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1
Aliases
LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZEJ, 3D6T
Band
12q12 · 15|15 E3
Bgee
buccal mucosa cell · monocyte · lower lobe of lung · blood · upper lobe of lung
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LRRK2 connects Entity context

The extracted context around LRRK2 shows recurring relationship patterns in the source. For example, LRRK2 → actin binding, amphisome, ATP binding, autolysosome, autophagy, axon, beta-catenin destruction complex binding, calcium-mediated signaling, canonical Wnt signaling pathway, caveola neck, cell differentiation, cell junction, cell projection, cellular response to dopamine, cellular response to manganese ion, cellular response to organic cyclic compound, cellular response to oxidative stress, cellular response to starvation, clathrin binding, co-receptor binding Another extracted example is LRRK2 → Achilles tendon, blood, buccal mucosa cell, granulocyte, human kidney, left lung, left lung lobe, lower lobe of lung, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lung, spleen, superior frontal gyrus, upper lobe of left lung, upper lobe of lung, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

LRRK2

Top relations

Gene ontology · 171
LRRK2 → actin binding, amphisome, ATP binding, autolysosome, autophagy, axon, beta-catenin destruction complex binding, calcium-mediated signaling, canonical Wnt signaling pathway, caveola neck, cell differentiation, cell junction, cell projection, cellular response to dopamine, cellular response to manganese ion, cellular response to organic cyclic compound, cellular response to oxidative stress, cellular response to starvation, clathrin binding, co-receptor binding
Bgee · 18
LRRK2 → Achilles tendon, blood, buccal mucosa cell, granulocyte, human kidney, left lung, left lung lobe, lower lobe of lung, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lung, spleen, superior frontal gyrus, upper lobe of left lung, upper lobe of lung, visceral pleura
RNA expression pattern · 18
LRRK2 → Achilles tendon, blood, buccal mucosa cell, granulocyte, human kidney, left lung, left lung lobe, lower lobe of lung, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lung, spleen, superior frontal gyrus, upper lobe of left lung, upper lobe of lung, visceral pleura
related to Function · 11
LRRK2 → ANK, ARM, C-terminal R2 RING, COR, Expression, GTPase, LRR, Possible, RAS, The LRRK2, WD40
related to Therapeutics development · 9
LRRK2 → ASOs, BIIB122, Biogen, Denali, In May, Multiple, Other, Parkinson's, There
related to External links · 5
LRRK2 → GeneReviews/NCBI/NIH/UW, LRRK2-Related Parkinson DiseaseLRRK2, Medicine Medical Subject Headings, MeSH, National Library
Band · 2
LRRK2 → 12q12, 15|15 E3
Chr. · 2
LRRK2 → Chromosome 12 (human), Chromosome 15 (mouse)
End · 2
LRRK2 → 40,369,285 bp, 91,700,323 bp
2.7.11.1 · 1
LRRK2 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

disease parkinson's kinase gene bp human activity chr band protein mutations leucine-rich repeat g2019s chromosome 12 development 40 mouse location

LRRK2 relationships Subject–Predicate–Object triples

TTTA extracted 258 structured relationships around LRRK2. Examples in this analysis include LRRK2 → 2.7.11.1 → ↗ and LRRK2 → Aliases → LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LRRK22.7.11.11.00infobox
LRRK2AliasesLRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 21.00infobox
LRRK2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZEJ, 3D6T1.00infobox
LRRK2Band12q121.00infobox
LRRK2Band15|15 E31.00infobox
LRRK2Bgeebuccal mucosa cell1.00infobox
LRRK2Bgeemonocyte1.00infobox
LRRK2Bgeelower lobe of lung1.00infobox
LRRK2Bgeeblood1.00infobox
LRRK2Bgeeupper lobe of lung1.00infobox
LRRK2Bgeeupper lobe of left lung1.00infobox
LRRK2Bgeeright lung1.00infobox
LRRK2BgeeAchilles tendon1.00infobox
LRRK2Bgeegranulocyte1.00infobox
LRRK2Bgeevisceral pleura1.00infobox
LRRK2Bgeehuman kidney1.00infobox
LRRK2Bgeeproximal tubule1.00infobox
LRRK2Bgeeleft lung1.00infobox
LRRK2Bgeeleft lung lobe1.00infobox
LRRK2Bgeeright kidney1.00infobox
LRRK2Bgeesuperior frontal gyrus1.00infobox
LRRK2Bgeelumbar spinal ganglion1.00infobox
LRRK2Bgeespleen1.00infobox
LRRK2BioGPSMore reference expression data1.00infobox
LRRK2Chr.Chromosome 12 (human)1.00infobox
LRRK2Chr.Chromosome 15 (mouse)1.00infobox
LRRK2DatabasesNCBI: entry; OMA: entry1.00infobox
LRRK2End40,369,285 bp1.00infobox
LRRK2End91,700,323 bp1.00infobox
LRRK2EnsemblENSG000001889061.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LRRK2 bring nearby vocabulary together. In this analysis, examples include Parkinson's, Activity and Development. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • LRRK2
    • Parkinson's
    • Activity
    • Development
    • Repeat
    • Expression
    • Function
    • Protein
    • Human
    • G2019s
    • Park8
    • Autophagy
    • Clinical
  • lrrk2
    • Parkinson's
    • Activity
    • Development
    • Repeat
    • Expression
    • Function
    • Protein
    • Human
    • G2019s
    • Park8
    • Autophagy
    • Clinical
  • kinase
    • Leucine-rich
    • Repeat
    • Activity
    • Development
    • Lrrk2
    • Gene
    • Dardarin
    • Enzyme
    • Park8
    • Autophagy
    • Clinical
    • Function
  • gene
    • Location
    • Chromosome
    • Development
    • Leucine-rich
    • Repeat
    • Bp
    • Chr
    • Human
    • Park8
    • Associated
    • Function
    • Mouse
  • leucine-rich repeat
    • Repeat
    • Dardarin
    • Enzyme
    • Park8
    • Kinase
    • Function
    • Location
    • Gene
    • Chromosome
    • Development
    • Bp
    • Chr
  • parkinson's disease
    • Parkinson's
    • Lrrk2
    • Gene
    • Associated
    • Cause
    • Mutation
    • Common
    • Mutations
    • G2019s
    • May
    • North
    • Activity
  • crohn's disease
    • Parkinson's
    • Lrrk2
    • Gene
    • Associated
    • Cause
    • Mutation
    • Common
    • Mutations
    • G2019s
    • May
    • North
    • Activity
  • mitochondrial function
    • Location
    • Mitochondrial
    • Chromosome
    • Leucine-rich
    • Repeat
    • Bp
    • Chr
    • Human
    • Activity
    • Gene
    • Park8
    • Autophagy

Connections between topic areas Semantic bridges

For LRRK2, one of the stronger structural bridges in this analysis connects LRRK2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LRRK2Function · splits 15 ⟂ 12
LRRK2Overview · splits 20 ⟂ 7
LRRK2Clinical significance · splits 20 ⟂ 7

Map overview Semantic statistics

LRRK2

Nodes27
Edges26
Triples258
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around LRRK2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LRRK2 · EN edition · Analysis: TopicsToTalkAbout

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