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LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a large, multifunctional kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene…

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2.7.11.1
↗
Aliases
LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZEJ, 3D6T
Band
12q12 · 15|15 E3
Bgee
buccal mucosa cell · monocyte · lower lobe of lung · blood · upper lobe of lung
BioGPS
More reference expression data

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Map overview Semantic statistics

LRRK2

Nodes27
Edges26
Triples258
Avg. degree1.93
Density0.074074
Components1

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LRRK2

Top relations

Gene ontology · 171
LRRK2 → actin binding, amphisome, ATP binding, autolysosome, autophagy, axon, beta-catenin destruction complex binding, calcium-mediated signaling, canonical Wnt signaling pathway, caveola neck, cell differentiation, cell junction, cell projection, cellular response to dopamine, cellular response to manganese ion, cellular response to organic cyclic compound, cellular response to oxidative stress, cellular response to starvation, clathrin binding, co-receptor binding
Bgee · 18
LRRK2 → Achilles tendon, blood, buccal mucosa cell, granulocyte, human kidney, left lung, left lung lobe, lower lobe of lung, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lung, spleen, superior frontal gyrus, upper lobe of left lung, upper lobe of lung, visceral pleura
RNA expression pattern · 18
LRRK2 → Achilles tendon, blood, buccal mucosa cell, granulocyte, human kidney, left lung, left lung lobe, lower lobe of lung, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lung, spleen, superior frontal gyrus, upper lobe of left lung, upper lobe of lung, visceral pleura
related to Function · 11
LRRK2 → ANK, ARM, C-terminal R2 RING, COR, Expression, GTPase, LRR, Possible, RAS, The LRRK2, WD40
related to Therapeutics development · 9
LRRK2 → ASOs, BIIB122, Biogen, Denali, In May, Multiple, Other, Parkinson's, There
related to External links · 5
LRRK2 → GeneReviews/NCBI/NIH/UW, LRRK2-Related Parkinson DiseaseLRRK2, Medicine Medical Subject Headings, MeSH, National Library
Band · 2
LRRK2 → 12q12, 15|15 E3
Chr. · 2
LRRK2 → Chromosome 12 (human), Chromosome 15 (mouse)
End · 2
LRRK2 → 40,369,285 bp, 91,700,323 bp
2.7.11.1 · 1
LRRK2 → ↗

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Important terminology

disease parkinson's kinase gene bp human activity chr band protein mutations leucine-rich repeat g2019s chromosome 12 development 40 mouse location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LRRK22.7.11.1↗1.00infobox
LRRK2AliasesLRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 21.00infobox
LRRK2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZEJ, 3D6T1.00infobox
LRRK2Band12q121.00infobox
LRRK2Band15|15 E31.00infobox
LRRK2Bgeebuccal mucosa cell1.00infobox
LRRK2Bgeemonocyte1.00infobox
LRRK2Bgeelower lobe of lung1.00infobox
LRRK2Bgeeblood1.00infobox
LRRK2Bgeeupper lobe of lung1.00infobox
LRRK2Bgeeupper lobe of left lung1.00infobox
LRRK2Bgeeright lung1.00infobox
LRRK2BgeeAchilles tendon1.00infobox
LRRK2Bgeegranulocyte1.00infobox
LRRK2Bgeevisceral pleura1.00infobox
LRRK2Bgeehuman kidney1.00infobox
LRRK2Bgeeproximal tubule1.00infobox
LRRK2Bgeeleft lung1.00infobox
LRRK2Bgeeleft lung lobe1.00infobox
LRRK2Bgeeright kidney1.00infobox
LRRK2Bgeesuperior frontal gyrus1.00infobox
LRRK2Bgeelumbar spinal ganglion1.00infobox
LRRK2Bgeespleen1.00infobox
LRRK2BioGPSMore reference expression data1.00infobox
LRRK2Chr.Chromosome 12 (human)1.00infobox
LRRK2Chr.Chromosome 15 (mouse)1.00infobox
LRRK2DatabasesNCBI: entry; OMA: entry1.00infobox
LRRK2End40,369,285 bp1.00infobox
LRRK2End91,700,323 bp1.00infobox
LRRK2EnsemblENSG000001889061.00infobox

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