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GSK-3: Inhibitors, Overview & Function

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety…

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GSK-3 topic overview

The analysis highlights Inhibitors, Overview and Function as prominent areas in the source structure around GSK-3.

Related topics
112
Source areas
6
Connected nodes
118
Extracted relationships
69
Concept neighborhoods
27
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 58 topics
Inhibitors · 32 topics
Function · 9 topics
Disease relevance · 8 topics
Glycogen synthase · 4 topics
Mechanism · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR039192
Available protein structures:
IPR039192
CDD
cd14137
InterPro
IPR039192
PDB
IPR039192
Symbol
STKc_GSK3

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanism

Glycogen synthase

Function

Disease relevance

Inhibitors

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GSK-3 connects Entity context

The extracted context around GSK-3 shows recurring relationship patterns in the source. For example, GSK-3 → AR-A014418, Ellison, Famotidine, GERD, GSK-3β, H2, H2-receptor, It, LEU-188, PRO-136, Strong, The, VAL, Zollinger Another extracted example is GSK-3 → Alzheimer's, Due, Elements, GSK-3's, Inhibition, Rev-ErbA, T2DM, The, There. Use these groups to spot repeated connection types before inspecting the individual relationships.

GSK-3

Top relations

related to Famotidine · 14
GSK-3 → AR-A014418, Ellison, Famotidine, GERD, GSK-3β, H2, H2-receptor, It, LEU-188, PRO-136, Strong, The, VAL, Zollinger
related to Disease relevance · 9
GSK-3 → Alzheimer's, Due, Elements, GSK-3's, Inhibition, Rev-ErbA, T2DM, The, There
related to Function · 7
GSK-3 → After, C-terminal, CK2, However, In, IRS1, Phosphorylation
related to Lithium · 6
GSK-3 → Also, Alzheimer's, GS, In, It, Lithium
related to Naproxen and Cromolyn · 6
GSK-3 → ARA014418, Both, C-peptide, GSK-3β, Naproxen, To
related to Pyrimidine derivatives · 4
GSK-3 → ATP-binding, GSK-3β, Pyrimidine, Some
related to Benefits of GSK-3β inhibitors · 3
GSK-3 → Alzheimer's, GSK-3β, In
related to Mechanism · 3
GSK-3 → ATP, C-terminal, The
is a · 2
GSK-3 → only type of glycogen synthase kinase named and recognized, serine/threonine protein kinase that phosphorylate either threonine or serine
AlphaFold · 1
GSK-3 → IPR039192

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

glycogen also gsk-3β glucose phosphorylation synthase activity kinase inhibitors shown cancer effects serine gsk3 protein inhibition disease insulin apoptosis residues

GSK-3 relationships Subject–Predicate–Object triples

TTTA extracted 69 structured relationships around GSK-3. Examples in this analysis include GSK-3 → AlphaFold → IPR039192 and GSK-3 → CDD → cd14137. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GSK-3AlphaFoldIPR0391921.00infobox
GSK-3Available protein structures:IPR0391921.00infobox
GSK-3CDDcd141371.00infobox
GSK-3InterProIPR0391921.00infobox
GSK-3PDBIPR0391921.00infobox
GSK-3SymbolSTKc_GSK31.00infobox
GSK-3is aserine/threonine protein kinase that phosphorylate either threonine or serine0.90text
GSK-3is aonly type of glycogen synthase kinase named and recognized0.90text
insulininstance ofIt is active in resting cells and is inhibited by several hormones0.80text
endothelial growth factorinstance ofIt is active in resting cells and is inhibited by several hormones0.80text
and platelet-derived growth factorinstance ofIt is active in resting cells and is inhibited by several hormones0.80text
p53instance ofGSK-3 can promote apoptosis by both activating pro-apoptotic factors0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around GSK-3 bring nearby vocabulary together. In this analysis, examples include Phosphorylation, Also and Inhibitors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GSK-3
    • Phosphorylation
    • Also
    • Inhibitors
    • Shown
    • Apoptosis
    • Signaling
    • Protein
    • Activity
    • Pathways
    • Cancer
    • Inhibition
    • Cellular
  • gsk-3
    • Phosphorylation
    • Also
    • Inhibitors
    • Shown
    • Apoptosis
    • Signaling
    • Protein
    • Activity
    • Pathways
    • Cancer
    • Inhibition
    • Cellular
  • serine/threonine protein kinase
    • Serine
    • Threonine
    • Residues
    • Phosphorylation
    • Synthase
    • Protein
    • Gsk3
    • Cellular
    • Kinase
    • Insulin
    • Glycogen
    • Addition
  • glycogen synthase
    • Synthase
    • Glucose
    • Kinase
    • Gsk-3β
    • Protein
    • Addition
    • Metabolism
    • Levels
    • Insulin
    • Serine
    • Threonine
    • Effects
  • alzheimer's disease
    • Disease
    • Diabetes
    • Bipolar
    • Disorder
    • Cancer
    • Inhibitors
    • Gsk-3β
    • Including
    • Citation
    • Famotidine
    • Needed
    • Effects
  • glycogen
    • Synthase
    • Glucose
    • Kinase
    • Gsk-3β
    • Addition
    • Metabolism
    • Levels
    • Insulin
    • Protein
    • Serine
    • Effects
    • Threonine
  • glucose 6-phosphate
    • Levels
    • Glycogen
    • Metabolism
    • Insulin
    • Gsk-3β
    • Effects
    • Shown
    • Including
    • Citation
    • Needed
    • Also
    • Famotidine
  • glycogen synthase kinases
    • Synthase
    • Glucose
    • Kinase
    • Gsk-3β
    • Protein
    • Addition
    • Metabolism
    • Levels
    • Insulin
    • Serine
    • Threonine
    • Effects

Connections between topic areas Semantic bridges

For GSK-3, one of the stronger structural bridges in this analysis connects GSK-3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GSK-3 — Overview · splits 60 ⟂ 59
GSK-3 — Inhibitors · splits 86 ⟂ 33
GSK-3 — Function · splits 109 ⟂ 10
GSK-3 — Disease relevance · splits 110 ⟂ 9
GSK-3 — Glycogen synthase · splits 114 ⟂ 5

Map overview Semantic statistics

GSK-3

Nodes119
Edges118
Triples69
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around GSK-3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Inhibitors, Overview & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GSK-3 · EN edition · Analysis: TopicsToTalkAbout

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