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RNF128: Regions, Interactions & Overview

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.

Language: English [EN]
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RNF128 topic overview

The analysis highlights Regions, Interactions and Overview as prominent areas in the source structure around RNF128.

Related topics
50
Source areas
9
Connected nodes
59
Extracted relationships
198
Concept neighborhoods
20
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics
Interactions · 10 topics
Protein Level Regulation · 6 topics
Transcript (mRNA) · 5 topics
Gene Level Regulation · 4 topics
Gene · 3 topics
Homology & Evolution · 3 topics
Clinical significance · 1 topics
Transcript Level Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27
Aliases
RNF128, GRAIL, ring finger protein 128, E3 ubiquitin protein ligase, ring finger protein 128
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ICU
Band
Xq22.3 · X|X F1
Bgee
jejunal mucosa · parotid gland · kidney tubule · duodenum · mucosa of colon
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Transcript (mRNA)

Gene Level Regulation

Transcript Level Regulation

Protein Level Regulation

Homology & Evolution

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RNF128 connects Entity context

The extracted context around RNF128 shows recurring relationship patterns in the source. For example, RNF128 → duodenum, epithelium of small intestine, epithelium of stomach, glomerulus, ileum, intestinal villus, jejunal mucosa, jejunum, kidney tubule, liver, mucosa of colon, mucosa of sigmoid colon, mucous cell of stomach, olfactory epithelium, pancreatic epithelial cell, parotid gland, pyloric antrum, right lobe of liver, seminal vesicula, transitional epithelium of urinary bladder Another extracted example is RNF128 → cytoplasm, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, Golgi apparatus, integral component of membrane, late endosome, membrane, metal ion binding, perinuclear region of cytoplasm, positive regulation of protein catabolic process in the vacuole, protein binding, protein deubiquitination, protein localization to lysosome, protein ubiquitination, regulation of protein stability, transferase activity, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process. Use these groups to spot repeated connection types before inspecting the individual relationships.

RNF128

Top relations

Bgee · 20
RNF128 → duodenum, epithelium of small intestine, epithelium of stomach, glomerulus, ileum, intestinal villus, jejunal mucosa, jejunum, kidney tubule, liver, mucosa of colon, mucosa of sigmoid colon, mucous cell of stomach, olfactory epithelium, pancreatic epithelial cell, parotid gland, pyloric antrum, right lobe of liver, seminal vesicula, transitional epithelium of urinary bladder
Gene ontology · 20
RNF128 → cytoplasm, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, Golgi apparatus, integral component of membrane, late endosome, membrane, metal ion binding, perinuclear region of cytoplasm, positive regulation of protein catabolic process in the vacuole, protein binding, protein deubiquitination, protein localization to lysosome, protein ubiquitination, regulation of protein stability, transferase activity, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process
RNA expression pattern · 20
RNF128 → duodenum, epithelium of small intestine, epithelium of stomach, glomerulus, ileum, intestinal villus, jejunal mucosa, jejunum, kidney tubule, liver, mucosa of colon, mucosa of sigmoid colon, mucous cell of stomach, olfactory epithelium, pancreatic epithelial cell, parotid gland, pyloric antrum, right lobe of liver, seminal vesicula, transitional epithelium of urinary bladder
related to Gene · 20
RNF128 → Anergy, E3, FLJ23516, Gene Related, GRAIL, Lymphocytes, Paralogs, RING, RNF13, RNF130, RNF133, RNF148, RNF149, RNF150, RNF167, RNF215, The, This, Xq22, ZNRF4
related to Interactions · 11
RNF128 → CD151, CD154, CD81, NSP8, OTUB1, SARS-Coronavirus RNA, TBK1, The NSP7, TP53, USP7, USP8
related to Protein Level Regulation · 11
RNF128 → At, Myristoylation, Out, Phosphorylation, Research, RGA, Sugars, The RNF128, There, These, This
related to Clinical significance · 9
RNF128 → CD4, CD83, Downregulation, IL2, IL4, In, It, Overexpression, P53
related to Orthologs · 8
RNF128 → EMBOSS Global, H2, Many, Moderately, RNF128's, Table, The, Then
related to Transcription Binding sites · 8
RNF128 → EGRF, HNF6, NFAT, RNF128's, Some, There, UTR, Wilms
related to Paralogs · 7
RNF128 → Although, Below, EMBOSS Needle, Percent, Table, The, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene expression ligase sites e3 orthologs ring human contains bp related isoform also transmembrane isoforms chr band peptide domain

RNF128 relationships Subject–Predicate–Object triples

TTTA extracted 198 structured relationships around RNF128. Examples in this analysis include RNF128 → 2.3.2.27 → ↗ and RNF128 → Aliases → RNF128, GRAIL, ring finger protein 128, E3 ubiquitin protein ligase, ring finger protein 128. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RNF1282.3.2.271.00infobox
RNF128AliasesRNF128, GRAIL, ring finger protein 128, E3 ubiquitin protein ligase, ring finger protein 1281.00infobox
RNF128Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ICU1.00infobox
RNF128BandXq22.31.00infobox
RNF128BandX|X F11.00infobox
RNF128Bgeejejunal mucosa1.00infobox
RNF128Bgeeparotid gland1.00infobox
RNF128Bgeekidney tubule1.00infobox
RNF128Bgeeduodenum1.00infobox
RNF128Bgeemucosa of colon1.00infobox
RNF128Bgeemucosa of sigmoid colon1.00infobox
RNF128Bgeepancreatic epithelial cell1.00infobox
RNF128Bgeeliver1.00infobox
RNF128Bgeeright lobe of liver1.00infobox
RNF128Bgeeglomerulus1.00infobox
RNF128Bgeetransitional epithelium of urinary bladder1.00infobox
RNF128Bgeeepithelium of small intestine1.00infobox
RNF128Bgeeepithelium of stomach1.00infobox
RNF128Bgeeolfactory epithelium1.00infobox
RNF128Bgeepyloric antrum1.00infobox
RNF128Bgeemucous cell of stomach1.00infobox
RNF128Bgeeileum1.00infobox
RNF128Bgeeintestinal villus1.00infobox
RNF128Bgeejejunum1.00infobox
RNF128Bgeeseminal vesicula1.00infobox
RNF128BioGPSMore reference expression data1.00infobox
RNF128Chr.X chromosome (human)1.00infobox
RNF128Chr.X chromosome (mouse)1.00infobox
RNF128DatabasesNCBI: entry; OMA: entry1.00infobox
RNF128End106,797,016 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RNF128 bring nearby vocabulary together. In this analysis, examples include Gene, Related and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • RNF128
    • Gene
    • Related
    • Expression
    • Ubiquitin-protein
    • Paralogs
    • Protein
    • Sites
    • Chromosome
    • Finger
    • Isoforms
    • Region
    • Human
  • rnf128
    • Gene
    • Related
    • Expression
    • Ubiquitin-protein
    • Paralogs
    • Protein
    • Sites
    • Chromosome
    • Finger
    • Isoforms
    • Region
    • Human
  • gene
    • Chromosome
    • Human
    • Ligase
    • Expression
    • Ubiquitin
    • Bp
    • Chr
    • Protein
    • Rnf128
    • Orthologs
    • Band
    • Ubiquitin-protein
  • protein
    • Sites
    • Ubiquitin
    • Glycosylation
    • Contains
    • Ring
    • Endocytic
    • Peptide
    • Transmembrane
    • Rnf128
    • Bp
    • Chr
    • Chromosome
  • type i transmembrane protein
    • Associated
    • Domain
    • Signal
    • Peptide
    • Ring
    • Endocytic
    • Finger
    • Sites
    • Ubiquitin
    • Glycosylation
    • Contains
    • Isoform
  • ring zinc-finger motif
    • Finger
    • Domain
    • Ubiquitin
    • Associated
    • Signal
    • Peptide
    • Transmembrane
    • Bp
    • Chr
    • Chromosome
    • Human
    • Isoform
  • e3 ubiquitin ligase
    • Ligase
    • Ubiquitin
    • Ubiquitin-protein
    • Ring
    • Liver
    • Bp
    • Chr
    • Chromosome
    • Expression
    • Finger
    • Gene
    • Transcription
  • ring finger domain
    • Finger
    • Ring
    • Transmembrane
    • Domain
    • Signal
    • Ubiquitin
    • Associated
    • Peptide
    • Bp
    • Chr
    • Chromosome
    • Human

Connections between topic areas Semantic bridges

For RNF128, one of the stronger structural bridges in this analysis connects RNF128 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RNF128Overview · splits 42 ⟂ 18
RNF128Interactions · splits 49 ⟂ 11
RNF128Protein Level Regulation · splits 53 ⟂ 7
RNF128Transcript (mRNA) · splits 54 ⟂ 6
RNF128Gene Level Regulation · splits 55 ⟂ 5
RNF128Gene · splits 56 ⟂ 4
RNF128Homology & Evolution · splits 56 ⟂ 4

Map overview Semantic statistics

RNF128

Nodes60
Edges59
Triples198
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around RNF128 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RNF128 · EN edition · Analysis: TopicsToTalkAbout

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