Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

IRF4

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation…

Immune cell development, Overview & Clinical significance

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around IRF4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLL
Band
6p25.3 · 13|13 A3.2
Bgee
lymph node · canal of the cervix · appendix · bone marrow cell · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Immune cell development

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

IRF4

Nodes72
Edges71
Triples158
Avg. degree1.97
Density0.027778
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

IRF4

Top relations

Gene ontology · 34
IRF4 → cytokine-mediated signaling pathway, cytosol, defense response to protozoan, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, histone H3 acetylation, histone H4 acetylation, immune system process, interferon-gamma-mediated signaling pathway, membrane, myeloid dendritic cell differentiation, negative regulation of toll-like receptor signaling pathway, nucleoplasm, nucleus, peptidyl-lysine methylation, positive regulation of cold-induced thermogenesis, positive regulation of DNA binding, positive regulation of transcription by RNA polymerase II
Bgee · 19
IRF4 → appendix, blood, bone marrow, bone marrow cell, brown adipose tissue, canal of the cervix, cartilage tissue, ectocervix, embryo, epithelium of colon, granulocyte, lymph node, mammary gland, mesenteric lymph nodes, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery
RNA expression pattern · 19
IRF4 → appendix, blood, bone marrow, bone marrow cell, brown adipose tissue, canal of the cervix, cartilage tissue, ectocervix, embryo, epithelium of colon, granulocyte, lymph node, mammary gland, mesenteric lymph nodes, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery
related to Interactions · 13
IRF4 → Aiolos, BATF3, BCL6, Blimp-1, CD40, GM-CSF, Ikaros, IL-4, IRF8, JMJD3, MMP12, NFATC2, SPI1
related to T cell differentiation · 12
IRF4 → BATF, BLIMP-1, CD4, CD8, For, In, RORγt, T-bet, Th17, Th2, Th2-associated, While
related to B cell differentiation · 11
IRF4 → Aiolos, B-cell-receptor, BCL6, BCR, GC, GCs, Ikaros, In, IRF8, POU2AF1, When IRF4
related to Immune cell development · 10
IRF4 → B-cell, BCL6, CD40, IL-4, In, Interferon Regulatory Factor, IRF, LPS, NFATs, T-cells
related to Clinical significance · 7
IRF4 → B-cell, IGH, In, MITF, The, The World Health Organization, This
related to External links · 7
IRF4 → FactorBookIRF4IRF4, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
IRF4 → 13|13 A3.2, 6p25.3

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells expression differentiation factor gene plasma development also transcription regulatory human cell irf8 essential bp chromosome chr band immune myeloid

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IRF4AliasesIRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 41.00infobox
IRF4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLL1.00infobox
IRF4Band6p25.31.00infobox
IRF4Band13|13 A3.21.00infobox
IRF4Bgeelymph node1.00infobox
IRF4Bgeecanal of the cervix1.00infobox
IRF4Bgeeappendix1.00infobox
IRF4Bgeebone marrow cell1.00infobox
IRF4Bgeecartilage tissue1.00infobox
IRF4Bgeespleen1.00infobox
IRF4Bgeeepithelium of colon1.00infobox
IRF4Bgeeectocervix1.00infobox
IRF4Bgeerectum1.00infobox
IRF4Bgeesuperficial temporal artery1.00infobox
IRF4Bgeemesenteric lymph nodes1.00infobox
IRF4Bgeeblood1.00infobox
IRF4Bgeesubcutaneous adipose tissue1.00infobox
IRF4Bgeegranulocyte1.00infobox
IRF4Bgeebrown adipose tissue1.00infobox
IRF4Bgeemammary gland1.00infobox
IRF4Bgeesubmandibular gland1.00infobox
IRF4Bgeebone marrow1.00infobox
IRF4Bgeeembryo1.00infobox
IRF4BioGPSMore reference expression data1.00infobox
IRF4Chr.Chromosome 6 (human)1.00infobox
IRF4Chr.Chromosome 13 (mouse)1.00infobox
IRF4DatabasesNCBI: entry; OMA: entry1.00infobox
IRF4End411,443 bp1.00infobox
IRF4End30,950,959 bp1.00infobox
IRF4EnsemblENSG000001372651.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.