IRF4

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IRF4 topic overview

The analysis highlights Immune cell development, Overview and Clinical significance as prominent areas in the source structure around IRF4.

Related topics: 67
Source areas: 4
Connected nodes: 71
Extracted relationships: 158
Concept neighborhoods: 30
Bridge connections: 71

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Immune cell development · 30 topics

Overview · 25 topics

Clinical significance · 6 topics

Interactions · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLL
Band: 6p25.3 · 13|13 A3.2
Bgee: lymph node · canal of the cervix · appendix · bone marrow cell · cartilage tissue
BioGPS: More reference expression data
Chr.: Chromosome 6 (human) · Chromosome 13 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Transcription factor
T lymphocytes T cell
B lymphocytes B cell
Myeloid cells
Oncogene
Tumor-suppressor Tumor suppressor gene
Long-lived plasma cells Plasma cell
Antibodies Antibody
Immunological memory
BLIMP-1 PRDM1
Zbtb20
Isotype class switch recombination Immunoglobulin class switching
AID enzyme Activation-induced cytidine deaminase
Immunoglobulin switch regions Immunoglobulin switch region
Somatic hypermutation
CD4+ DCs CD4
CD8+ DCs CD8
GM-CSF Granulocyte-macrophage colony-stimulating factor
Monocyte-derived dendritic cells (Mo-DCs) Dendritic cell
Common myeloid progenitors (CMPs) CFU-GEMM
M2 macrophages M2 macrophage
JMJD3 KDM6B
M2 macrophage polarization Macrophage polarization

Immune cell development

Interferon Regulatory Factor (IRF) Interferon regulatory factors
Lipopolysaccharide (LPS) Lipopolysaccharide
IL-4 Interleukin-4 receptor
CD40 CD40 (protein)
B-cell lymphoma 6 protein (BCL6) BCL6
Nuclear factor of activated T-cells (NFATs) NFAT
Macrophages Macrophage
CD4+ T helper cells CD4+ helper cells
Th2 cells T helper cell
Th17 cells Th17 cell
Apoptosis
Cytokine production Cytokine
Naïve T cells Naive T cell
Effector Effector T Cell
Memory T cells Memory T cell
CD8+ cytotoxic T cell differentiation Cytotoxic T cell
BATF BATF (gene)
T-bet TBX21
RORγt RAR-related orphan receptor gamma
T regulatory cells T regulatory cell
IRF8
Ikaros Ikaros transcription factor
Aiolos IKZF3
Κ and λ chains Immunoglobulin light chain
BCR B-cell receptor
Adaptive immune response
Germinal centers (GCs) Germinal center
Spleen
Lymph nodes Lymph node
POU2AF1

Clinical significance

MITF Microphthalmia-associated transcription factor
Large B-cell lymphoma
Large B-cell lymphoma with IRF4 rearrangement Pediatric-type follicular lymphoma
Overexpression Glossary of genetics
Translocation Chromosomal translocation
IGH@ immunoglobulin heavy locus IGH@

Interactions

Interact Protein-protein interaction
Blimp-1
MMP12
NFATC2
SPI1
STAT6

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IRF4 connects Entity context

The extracted context around IRF4 shows recurring relationship patterns in the source. For example, IRF4 → cytokine-mediated signaling pathway, cytosol, defense response to protozoan, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, histone H3 acetylation, histone H4 acetylation, immune system process, interferon-gamma-mediated signaling pathway, membrane, myeloid dendritic cell differentiation, negative regulation of toll-like receptor signaling pathway, nucleoplasm, nucleus, peptidyl-lysine methylation, positive regulation of cold-induced thermogenesis, positive regulation of DNA binding, positive regulation of transcription by RNA polymerase II Another extracted example is IRF4 → appendix, blood, bone marrow, bone marrow cell, brown adipose tissue, canal of the cervix, cartilage tissue, ectocervix, embryo, epithelium of colon, granulocyte, lymph node, mammary gland, mesenteric lymph nodes, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 34

IRF4 → cytokine-mediated signaling pathway, cytosol, defense response to protozoan, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, histone H3 acetylation, histone H4 acetylation, immune system process, interferon-gamma-mediated signaling pathway, membrane, myeloid dendritic cell differentiation, negative regulation of toll-like receptor signaling pathway, nucleoplasm, nucleus, peptidyl-lysine methylation, positive regulation of cold-induced thermogenesis, positive regulation of DNA binding, positive regulation of transcription by RNA polymerase II

Bgee · 19

IRF4 → appendix, blood, bone marrow, bone marrow cell, brown adipose tissue, canal of the cervix, cartilage tissue, ectocervix, embryo, epithelium of colon, granulocyte, lymph node, mammary gland, mesenteric lymph nodes, rectum, spleen, subcutaneous adipose tissue, submandibular gland, superficial temporal artery

RNA expression pattern · 19

related to Interactions · 13

IRF4 → Aiolos, BATF3, BCL6, Blimp-1, CD40, GM-CSF, Ikaros, IL-4, IRF8, JMJD3, MMP12, NFATC2, SPI1

related to T cell differentiation · 12

IRF4 → BATF, BLIMP-1, CD4, CD8, For, In, RORγt, T-bet, Th17, Th2, Th2-associated, While

related to B cell differentiation · 11

IRF4 → Aiolos, B-cell-receptor, BCL6, BCR, GC, GCs, Ikaros, In, IRF8, POU2AF1, When IRF4

related to Immune cell development · 10

IRF4 → B-cell, BCL6, CD40, IL-4, In, Interferon Regulatory Factor, IRF, LPS, NFATs, T-cells

related to Clinical significance · 7

IRF4 → B-cell, IGH, In, MITF, The, The World Health Organization, This

related to External links · 7

IRF4 → FactorBookIRF4IRF4, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

Band · 2

IRF4 → 13|13 A3.2, 6p25.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells expression differentiation factor gene plasma development also transcription regulatory human cell irf8 essential bp chromosome chr band immune myeloid

IRF4 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around IRF4. Examples in this analysis include IRF4 → Aliases → IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4 and IRF4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLL. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
IRF4	Aliases	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4	1.00	infobox
IRF4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DLL	1.00	infobox
IRF4	Band	6p25.3	1.00	infobox
IRF4	Band	13\|13 A3.2	1.00	infobox
IRF4	Bgee	lymph node	1.00	infobox
IRF4	Bgee	canal of the cervix	1.00	infobox
IRF4	Bgee	appendix	1.00	infobox
IRF4	Bgee	bone marrow cell	1.00	infobox
IRF4	Bgee	cartilage tissue	1.00	infobox
IRF4	Bgee	spleen	1.00	infobox
IRF4	Bgee	epithelium of colon	1.00	infobox
IRF4	Bgee	ectocervix	1.00	infobox
IRF4	Bgee	rectum	1.00	infobox
IRF4	Bgee	superficial temporal artery	1.00	infobox
IRF4	Bgee	mesenteric lymph nodes	1.00	infobox
IRF4	Bgee	blood	1.00	infobox
IRF4	Bgee	subcutaneous adipose tissue	1.00	infobox
IRF4	Bgee	granulocyte	1.00	infobox
IRF4	Bgee	brown adipose tissue	1.00	infobox
IRF4	Bgee	mammary gland	1.00	infobox
IRF4	Bgee	submandibular gland	1.00	infobox
IRF4	Bgee	bone marrow	1.00	infobox
IRF4	Bgee	embryo	1.00	infobox
IRF4	BioGPS	More reference expression data	1.00	infobox
IRF4	Chr.	Chromosome 6 (human)	1.00	infobox
IRF4	Chr.	Chromosome 13 (mouse)	1.00	infobox
IRF4	Databases	NCBI: entry; OMA: entry	1.00	infobox
IRF4	End	411,443 bp	1.00	infobox
IRF4	End	30,950,959 bp	1.00	infobox
IRF4	Ensembl	ENSG00000137265	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IRF4 bring nearby vocabulary together. In this analysis, examples include Cells, Expression and Differentiation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

IRF4
- Cells
- Expression
- Differentiation
- Cell
- Development
- Plasma
- Essential
- Regulatory
- Transcription
- Factors
- Irf8
- Necessary
irf4
- Cells
- Expression
- Differentiation
- Cell
- Development
- Plasma
- Essential
- Regulatory
- Transcription
- Factors
- Irf8
- Necessary
gene
- Location
- Interferon
- Bp
- Chr
- Chromosome
- Human
- Regulatory
- Mum1
- Band
- Protein
- Dendritic
- Immune
transcription factor
- Factors
- Regulatory
- Factor
- Transcription
- Function
- Interferon
- Protein
- Immune
- Human
- Irf8
- Also
- Gene
myeloid cells
- Irf4
- Macrophages
- Plasma
- Expression
- Necessary
- Factors
- Germinal
- Regulatory
- Transcription
- Essential
- Dendritic
- Immune
long-lived plasma cells
- Irf4
- Plasma
- Germinal
- Center
- Role
- Expression
- Necessary
- Essential
- Dendritic
- Immune
- Long-lived
- Macrophages
monocyte-derived dendritic cells (mo-dcs)
- Irf4
- Immune
- Macrophages
- Myeloid
- Location
- Plasma
- Dcs
- Interferon
- Bp
- Chr
- Chromosome
- Expression
interferon regulatory factor (irf)
- Protein
- Regulatory
- Human
- Location
- Mum1
- Gene
- Transcription
- Factor
- Function
- Interferon
- Bp
- Chr

Connections between topic areas Semantic bridges

For IRF4, one of the stronger structural bridges in this analysis connects IRF4 with Immune cell development. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

IRF4 — Immune cell development · splits 41 ⟂ 31

IRF4 — Overview · splits 46 ⟂ 26

IRF4 — Clinical significance · splits 65 ⟂ 7

IRF4 — Interactions · splits 65 ⟂ 7

Map overview Semantic statistics

IRF4

Nodes72

Edges71

Triples158

Avg. degree1.97

Density0.027778

Components1

Source & methodology

TTTA analyzes the structure around IRF4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Immune cell development, Overview & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IRF4 · EN edition · Analysis: TopicsToTalkAbout