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CASS4: History, Disease association & History and discovery

Cas scaffolding protein family member 4 is a protein that in humans is encoded by the CASS4 gene.

Language: English [EN]
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CASS4 topic overview

The analysis highlights History, Disease association and History and discovery as prominent areas in the source structure around CASS4.

Related topics
51
Source areas
8
Connected nodes
59
Extracted relationships
217
Concept neighborhoods
17
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Disease association · 15 topics
Gene · 11 topics
Structure · 8 topics
History and discovery · 6 topics
Overview · 5 topics
Protein family · 3 topics
Function · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CASS4, C20orf32, CAS4, HEFL, HEPL, Cas scaffolding protein family member 4, Cas scaffold protein family member 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRE
Band
20q13.31 · 2|2 H3
Bgee
upper lobe of left lung · blood · right lung · granulocyte · appendix
BioGPS
n/a
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History and discovery

Gene

Protein family

Structure

Function

Disease association

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CASS4 connects Entity context

The extracted context around CASS4 shows recurring relationship patterns in the source. For example, CASS4 → Areb6, C/EBP, C/EBPα, C20orf32, CHOP-10, Cumulatively, E-box, Ensembl, ENSG00000087589, Entrez Gene, GRChB38p2, HEF-like, HEF1-Efs-p130Cas-like, HEFL, HEPL, HGNC, HGNC-approved, In, LCR-F1, MAX1 Another extracted example is CASS4 → All CAS, Also, Although, Amino, BCAR1, Carboxy-terminal, CAS, EFS, FAK, FAK C-terminus, FAT, FAT-like, For, Further, In, Isoform, It, N-terminal, NEDD9, SH2. Use these groups to spot repeated connection types before inspecting the individual relationships.

CASS4

Top relations

related to Gene · 34
CASS4 → Areb6, C/EBP, C/EBPα, C20orf32, CHOP-10, Cumulatively, E-box, Ensembl, ENSG00000087589, Entrez Gene, GRChB38p2, HEF-like, HEF1-Efs-p130Cas-like, HEFL, HEPL, HGNC, HGNC-approved, In, LCR-F1, MAX1
related to Structure · 27
CASS4 → All CAS, Also, Although, Amino, BCAR1, Carboxy-terminal, CAS, EFS, FAK, FAK C-terminus, FAT, FAT-like, For, Further, In, Isoform, It, N-terminal, NEDD9, SH2
Bgee · 17
CASS4 → appendix, blood, bone marrow, buccal mucosa cell, embryo, epiblast, gallbladder, granulocyte, left lung lobe, mesenteric lymph nodes, monocyte, right lung, right lung lobe, sciatic nerve, spleen, testicle, upper lobe of left lung
RNA expression pattern · 17
CASS4 → appendix, blood, bone marrow, buccal mucosa cell, embryo, epiblast, gallbladder, granulocyte, left lung lobe, mesenteric lymph nodes, monocyte, right lung, right lung lobe, sciatic nerve, spleen, testicle, upper lobe of left lung
related to Alzheimer's disease · 14
CASS4 → AD, Alzheimer's, APP, CAS-family, CASS4 SNPs, Given, GWAS, However, In, Several, SNP, T/C, T/G, Two
related to Function · 14
CASS4 → BCAR1, Because, CAS, CRKL, Direct, FAK, SH2, SH3, Singh, Src, The, These, This, Unusually
Gene ontology · 13
CASS4 → actin filament reorganization, cell adhesion, cell junction, cell migration, cytoplasm, cytoskeleton, focal adhesion, plasma membrane, positive regulation of cell migration, positive regulation of protein tyrosine kinase activity, positive regulation of substrate adhesion-dependent cell spreading, protein tyrosine kinase binding, structural constituent of cytoskeleton
related to history · 13
CASS4 → CAS, CAS-related, Crk, EFS, Gene Nomenclature Committee, HEF1-EFS-p130Cas-like, HEPL, HGNC, HUGO, Human Genome Organization, NEDD9/HEF1, Singh, The
related to Cancer · 11
CASS4 → A549, BE1, Changes, H1299, In, LTE, Many CAS, Miao, NSCLC, These, TNM
related to Protein family · 9
CASS4 → BCAR1, CAS, Drosophila, EFS, Evolutionary, In, NEDD9/HEF1, Singh, There

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

family cas protein gene human may domain members 20 bp function also p130cas bcar1 member chr band proteins chromosome cancer

CASS4 relationships Subject–Predicate–Object triples

TTTA extracted 217 structured relationships around CASS4. Examples in this analysis include CASS4 → Aliases → CASS4, C20orf32, CAS4, HEFL, HEPL, Cas scaffolding protein family member 4, Cas scaffold protein family member 4 and CASS4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRE. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CASS4AliasesCASS4, C20orf32, CAS4, HEFL, HEPL, Cas scaffolding protein family member 4, Cas scaffold protein family member 41.00infobox
CASS4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CRE1.00infobox
CASS4Band20q13.311.00infobox
CASS4Band2|2 H31.00infobox
CASS4Bgeeupper lobe of left lung1.00infobox
CASS4Bgeeblood1.00infobox
CASS4Bgeeright lung1.00infobox
CASS4Bgeegranulocyte1.00infobox
CASS4Bgeeappendix1.00infobox
CASS4Bgeemonocyte1.00infobox
CASS4Bgeetesticle1.00infobox
CASS4Bgeebuccal mucosa cell1.00infobox
CASS4Bgeegallbladder1.00infobox
CASS4Bgeespleen1.00infobox
CASS4Bgeeleft lung lobe1.00infobox
CASS4Bgeeembryo1.00infobox
CASS4Bgeebone marrow1.00infobox
CASS4Bgeeright lung lobe1.00infobox
CASS4Bgeemesenteric lymph nodes1.00infobox
CASS4Bgeesciatic nerve1.00infobox
CASS4Bgeeepiblast1.00infobox
CASS4BioGPSn/a1.00infobox
CASS4Chr.Chromosome 20 (human)1.00infobox
CASS4Chr.Chromosome 2 (mouse)1.00infobox
CASS4DatabasesNCBI: entry; OMA: entry1.00infobox
CASS4End56,460,387 bp1.00infobox
CASS4End172,275,677 bp1.00infobox
CASS4EnsemblENSG000000875891.00infobox
CASS4Entrez570911.00infobox
CASS4External IDsMGI: 2444482; GeneCards: CASS41.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CASS4 bring nearby vocabulary together. In this analysis, examples include May, Protein and Family. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CASS4
    • May
    • Protein
    • Family
    • Human
    • Gene
    • Function
    • Also
    • Expression
    • P130cas
    • Members
    • Ad
    • Lung
  • cass4
    • May
    • Protein
    • Family
    • Human
    • Gene
    • Function
    • Also
    • Expression
    • P130cas
    • Members
    • Ad
    • Lung
  • cas protein family
    • Family
    • Members
    • Member
    • Protein
    • Proteins
    • Also
    • Cass4
    • Sh3
    • Binding
    • Bcar1
    • P130cas
    • Function
  • non-small cell lung cancer
    • Lung
    • Study
    • Clinical
    • Nedd9
    • Binding
    • Cell
    • Expression
    • Member
    • Function
    • Family
    • Protein
    • Al
  • protein family
    • Members
    • Member
    • Protein
    • Also
    • Cass4
    • Sh3
    • Bcar1
    • Binding
    • P130cas
    • Function
    • Proteins
    • Human
  • function
    • Expression
    • Al
    • Bp
    • Chr
    • Chromosome
    • Et
    • Location
    • Lung
    • Regulation
    • Study
    • Human
    • Cancer
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Member
    • Protein
    • Band
    • Lung
    • Expression
    • Function
    • Al
  • gene nomenclature
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Member
    • Protein
    • Band
    • Lung
    • Expression
    • Function
    • Al

Connections between topic areas Semantic bridges

For CASS4, one of the stronger structural bridges in this analysis connects CASS4 with Disease association. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CASS4Disease association · splits 44 ⟂ 16
CASS4Gene · splits 48 ⟂ 12
CASS4Structure · splits 51 ⟂ 9
CASS4History and discovery · splits 53 ⟂ 7
CASS4Overview · splits 54 ⟂ 6
CASS4Protein family · splits 56 ⟂ 4
CASS4Function · splits 57 ⟂ 3

Map overview Semantic statistics

CASS4

Nodes60
Edges59
Triples217
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around CASS4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Disease association & History and discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CASS4 · EN edition · Analysis: TopicsToTalkAbout

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