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G2 phase

The G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated. G2 phase ends with the onset of prophase, the first phase of mitosis in which the cell’s chromatin condenses into chromosomes.

End of G2/entry into mitosis, Overview & G2/M DNA damage arrest

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End of G2/entry into mitosis

36 related topics

Overview

19 related topics

G2/M DNA damage arrest

8 related topics

Medical relevance

4 related topics

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Overview

Homologous recombinational repair

End of G2/entry into mitosis

G2/M DNA damage arrest

Medical relevance

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G2 phase

Nodes76
Edges75
Triples34
Avg. degree1.97
Density0.026316
Components1

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G2 phase

Top relations

related to G2/M DNA damage arrest · 18
G2 phase → ATM, ATR, B1, Cdc25, CDK1, Cells, Chk1, Cyclin B1, Cyclin B1/CDK1, DNA, G2, G2/M, Gadd45, Inactive Cyclin B1/CDK1, Long-term, M-phase, P53, The
related to Homologous recombinational repair · 5
G2 phase → DNA, During, G2, M-phase, Thus
is a · 1
G2 phase → period of rapid cell growth and protein synthesis during which the cell prepares itself for mitosis

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Important terminology

g2 cdk1 cyclin b1 phase cell activity dna mitosis wee1 transition also nucleus m-phase cdc25 cells cyclin-b1 phosphorylation interphase bistable

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
G2 phaseis aperiod of rapid cell growth and protein synthesis during which the cell prepares itself for mitosis0.90text
NF-Yinstance ofin response to phosphorylation of transcription factors0.80text
FoxM1instance ofin response to phosphorylation of transcription factors0.80text
B-Myb by upstream G1instance ofin response to phosphorylation of transcription factors0.80text
G1/S cyclin-CDK complexes.Regulation of cyclin-B1/CDK1 activityIncreased levels of cyclin B1 cause rising levels of cyclin B1-CDK1 complexes throughout G2instance ofin response to phosphorylation of transcription factors0.80text
but the complex remains inactive prior to the G2/M transition due to inhibitory phosphorylation by the Wee1instance ofin response to phosphorylation of transcription factors0.80text
Myt1 kinasesinstance ofin response to phosphorylation of transcription factors0.80text
G1/S cyclin-CDK complexesinstance ofin response to phosphorylation of transcription factors0.80text
homology-directed repairinstance ofeffectively stalling the cell in G2 until the damage is repaired by mechanisms0.80text
p53instance ofoftentimes downstream of loss of tumor suppressors0.80text
can cause an increase in cell proliferationinstance ofoftentimes downstream of loss of tumor suppressors0.80text
G2 phaserelated to G2/M DNA damage arrestCells0.60section

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