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The G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated. G2 phase ends with the onset of prophase, the first phase of mitosis in which the cell’s chromatin condenses into chromosomes.
End of G2/entry into mitosis, Overview & G2/M DNA damage arrest
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g2 cdk1 cyclin b1 phase cell activity dna mitosis wee1 transition also nucleus m-phase cdc25 cells cyclin-b1 phosphorylation interphase bistable
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| G2 phase | is a | period of rapid cell growth and protein synthesis during which the cell prepares itself for mitosis | 0.90 | text |
| NF-Y | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| FoxM1 | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| B-Myb by upstream G1 | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| G1/S cyclin-CDK complexes.Regulation of cyclin-B1/CDK1 activityIncreased levels of cyclin B1 cause rising levels of cyclin B1-CDK1 complexes throughout G2 | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| but the complex remains inactive prior to the G2/M transition due to inhibitory phosphorylation by the Wee1 | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| Myt1 kinases | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| G1/S cyclin-CDK complexes | instance of | in response to phosphorylation of transcription factors | 0.80 | text |
| homology-directed repair | instance of | effectively stalling the cell in G2 until the damage is repaired by mechanisms | 0.80 | text |
| p53 | instance of | oftentimes downstream of loss of tumor suppressors | 0.80 | text |
| can cause an increase in cell proliferation | instance of | oftentimes downstream of loss of tumor suppressors | 0.80 | text |
| G2 phase | related to G2/M DNA damage arrest | Cells | 0.60 | section |
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