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Transforming growth factor beta

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.

Standards, Clinical significance & Signaling pathways

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Overview

Structure

Latent TGF-β complex

Integrin-independent activation

Activation by Alpha(V) containing integrins

Signaling pathways

TGFβ receptor inhibitors

TGF-β mimic

Effects on immune cells

Clinical significance

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Map overview Semantic statistics

Transforming growth factor beta

Nodes113
Edges112
Triples13
Avg. degree1.98
Density0.017699
Components1

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Important terminology Word statistics

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Important terminology

tgf-β cells cell signaling complex also pathway latent role tgf-β1 protein activation macrophages receptor immune lap active may kinase proteins

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
plasmin catalyze the release of active TGF-β from the complexinstance ofSerum proteinases0.80text
epidermal growth factorinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
whereas the JNKinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
p38 MAPK are activated by the MAPK kinaseinstance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
activated themselves by the TGF-β-activated kinase-1instance ofERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli0.80text
c-mycinstance ofand repressing other key regulatory genes0.80text
ATMinstance ofand repressing other key regulatory genes0.80text
IL-10instance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
IL-35instance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
and TGF-β.Liver fibrosisTGF-β1 has been implicated in the process of activating hepatic stellate cellsinstance ofmight be involved in cancer progression like gastric cancer through influencing Tregs function and the secretion of immunomodulatory cytokines0.80text
mitral valve prolapseinstance ofectopia lentis and heart complications0.80text
aortic enlargement increasing the likelihood of aortic dissectioninstance ofectopia lentis and heart complications0.80text

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