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Aurora kinase A

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

Aurora kinase family, Mitosis & Clinical significance

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2.7.11.1
Aliases
AURKA, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UZH, 1MQ4, 1MUO, 1OL5, 1OL6, 1OL7, 2BMC, 2C6D, 2C6E, 2DWB, 2J4Z, 2J50, 2NP8, 2W1C, 2W1D, 2W1E, 2W1F, 2W1G,…
Band
20q13.2 · 2 H3|2 94.84 cM
Bgee
oocyte · secondary oocyte · ventricular zone · sperm · gonad
BioGPS
More reference expression data

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Discovery

Aurora kinase family

Localization

Mitosis

Meiosis

Clinical significance

Interactions

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Map overview Semantic statistics

Aurora kinase A

Nodes64
Edges63
Triples151
Avg. degree1.97
Density0.03125
Components1

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Aurora kinase A

Top relations

Gene ontology · 74
Aurora kinase A → anaphase-promoting complex-dependent catabolic process, anterior/posterior axis specification, ATP binding, axon hillock, cell cycle, cell division, cell projection, cell projection organization, centriole, centrosome, centrosome cycle, centrosome localization, chromosome passenger complex, cilium, cytoplasm, cytoskeleton, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, G2/M transition of mitotic cell cycle, germinal vesicle
Bgee · 18
Aurora kinase A → amniotic fluid, embryo, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, gonad, morula, oocyte, otic placode, otic vesicle, primary oocyte, secondary oocyte, seminiferous tubule, sperm, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 18
Aurora kinase A → amniotic fluid, embryo, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, gonad, morula, oocyte, otic placode, otic vesicle, primary oocyte, secondary oocyte, seminiferous tubule, sperm, testicle, trabecular bone, ventricular zone, zygote
related to Aurora kinase family · 8
Aurora kinase A → Aurora, C-terminal, Caenorhabditis, Drosophila, In, The, The Xenopus, Their N-terminal
related to External links · 8
Aurora kinase A → APDBe-KB, AURKA, Human AURKA, Human Aurora, Mouse Aurora, PDB, PDBe-KB, UCSC Genome Browser
Band · 2
Aurora kinase A → 2 H3|2 94.84 cM, 20q13.2
Chr. · 2
Aurora kinase A → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
Aurora kinase A → 172,212,455 bp, 56,392,337 bp
2.7.11.1 · 1
Aurora kinase A → ↗
Aliases · 1
Aurora kinase A → AURKA, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A

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Important terminology

aurora kinase mitotic mitosis spindle protein cell meiosis human chromosome centrosome bp microtubules gene chr band proper aurka cytokinesis xenopus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Aurora kinase A2.7.11.11.00infobox
Aurora kinase AAliasesAURKA, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A1.00infobox
Aurora kinase AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4UZH, 1MQ4, 1MUO, 1OL5, 1OL6, 1OL7, 2BMC, 2C6D, 2C6E, 2DWB, 2J4Z, 2J50, 2NP8, 2W1C, 2W1D, 2W1E, 2W1F, 2W1G,…1.00infobox
Aurora kinase ABand20q13.21.00infobox
Aurora kinase ABand2 H3|2 94.84 cM1.00infobox
Aurora kinase ABgeeoocyte1.00infobox
Aurora kinase ABgeesecondary oocyte1.00infobox
Aurora kinase ABgeeventricular zone1.00infobox
Aurora kinase ABgeesperm1.00infobox
Aurora kinase ABgeegonad1.00infobox
Aurora kinase ABgeetrabecular bone1.00infobox
Aurora kinase ABgeeembryo1.00infobox
Aurora kinase ABgeeganglionic eminence1.00infobox
Aurora kinase ABgeeamniotic fluid1.00infobox
Aurora kinase ABgeetesticle1.00infobox
Aurora kinase ABgeezygote1.00infobox
Aurora kinase ABgeemorula1.00infobox
Aurora kinase ABgeeotic vesicle1.00infobox
Aurora kinase ABgeeseminiferous tubule1.00infobox
Aurora kinase ABgeeotic placode1.00infobox
Aurora kinase ABgeefetal liver hematopoietic progenitor cell1.00infobox
Aurora kinase ABgeeepiblast1.00infobox
Aurora kinase ABgeeprimary oocyte1.00infobox
Aurora kinase ABioGPSMore reference expression data1.00infobox
Aurora kinase AChr.Chromosome 20 (human)1.00infobox
Aurora kinase AChr.Chromosome 2 (mouse)1.00infobox
Aurora kinase ADatabasesNCBI: entry; OMA: entry1.00infobox
Aurora kinase AEnd56,392,337 bp1.00infobox
Aurora kinase AEnd172,212,455 bp1.00infobox
Aurora kinase AEnsemblENSG000000875861.00infobox

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