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DDX3X

ATP-dependent RNA helicase DDX3X is an enzyme that in humans is encoded by the DDX3X gene.

Role in cancer, Function & Clinical significance

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3.6.4.13
Aliases
DDX3X, DBX, DDX14, DDX3, HLP2, CAP-Rf, MRX102, DEAD-box helicase 3, X-linked, DEAD-box helicase 3 X-linked, MRXSSB
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I4I, 2JGN, 3JRV, 4O2C, 4O2E, 4O2F, 4PX9, 4PXA, 5E7J, 5E7M, 5E7I
Band
Xp11.4 · X A1.1|X 8.17 cM
Bgee
Epithelium of choroid plexus · oocyte · sperm · secondary oocyte · palpebral conjunctiva
BioGPS
More reference expression data

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Overview

Function

Role in cancer

Clinical significance

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Map overview Semantic statistics

DDX3X

Nodes42
Edges41
Triples174
Avg. degree1.95
Density0.047619
Components1

How this topic connects Entity context

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DDX3X

Top relations

Gene ontology · 80
DDX3X → apoptotic process, ATP binding, ATPase activity, cadherin binding, cellular response to arsenic-containing substance, cellular response to osmotic stress, chromosome segregation, CTPase activity, cytoplasm, cytoplasmic stress granule, cytosol, cytosolic small ribosomal subunit, DNA binding, DNA duplex unwinding, DNA helicase activity, eukaryotic initiation factor 4E binding, eukaryotic translation initiation factor 3 complex, extracellular exosome, extracellular region, extrinsic apoptotic signaling pathway via death domain receptors
Bgee · 20
DDX3X → cumulus cell, Epithelium of choroid plexus, epithelium of colon, epithelium of stomach, genital tubercle, human fetus, lacrimal gland, lactiferous duct, mandibular prominence, maxillary prominence, mucosa of paranasal sinus, oocyte, palpebral conjunctiva, primitive streak, secondary oocyte, skin of hip, sperm, tail of embryo, tibia, ureter
RNA expression pattern · 20
DDX3X → cumulus cell, Epithelium of choroid plexus, epithelium of colon, epithelium of stomach, genital tubercle, human fetus, lacrimal gland, lactiferous duct, mandibular prominence, maxillary prominence, mucosa of paranasal sinus, oocyte, palpebral conjunctiva, primitive streak, secondary oocyte, skin of hip, sperm, tail of embryo, tibia, ureter
related to Function · 10
DDX3X → Asp-Glu-Ala-Asp, Based, DEAD, HART, RNA, The, They, This, UTR, Y-linked
related to Role in cancer · 9
DDX3X → Cyclin E1, For, HIF1A, In HeLa, Increased, MDA-MB-231, More, Since, UTR
related to Sub-cellular trafficking · 6
DDX3X → At, CRM1, It, NES, Ran-GTP, Ran-GTP-dependent
related to Clinical significance · 3
DDX3X → ADHD, In, Mutations
Band · 2
DDX3X → X A1.1|X 8.17 cM, Xp11.4
Chr. · 2
DDX3X → X chromosome (human), X chromosome (mouse)
End · 2
DDX3X → 13,160,291 bp, 41,364,472 bp

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Important terminology

gene bp helicase expression translation chr human band melanoma chromosome rna cells activity mrna location vemurafenib mitf binding protein nuclear

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DDX3X3.6.4.131.00infobox
DDX3XAliasesDDX3X, DBX, DDX14, DDX3, HLP2, CAP-Rf, MRX102, DEAD-box helicase 3, X-linked, DEAD-box helicase 3 X-linked, MRXSSB1.00infobox
DDX3XAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I4I, 2JGN, 3JRV, 4O2C, 4O2E, 4O2F, 4PX9, 4PXA, 5E7J, 5E7M, 5E7I1.00infobox
DDX3XBandXp11.41.00infobox
DDX3XBandX A1.1|X 8.17 cM1.00infobox
DDX3XBgeeEpithelium of choroid plexus1.00infobox
DDX3XBgeeoocyte1.00infobox
DDX3XBgeesperm1.00infobox
DDX3XBgeesecondary oocyte1.00infobox
DDX3XBgeepalpebral conjunctiva1.00infobox
DDX3XBgeelactiferous duct1.00infobox
DDX3XBgeetibia1.00infobox
DDX3XBgeemucosa of paranasal sinus1.00infobox
DDX3XBgeeskin of hip1.00infobox
DDX3XBgeeepithelium of colon1.00infobox
DDX3XBgeemaxillary prominence1.00infobox
DDX3XBgeecumulus cell1.00infobox
DDX3XBgeehuman fetus1.00infobox
DDX3XBgeetail of embryo1.00infobox
DDX3XBgeemandibular prominence1.00infobox
DDX3XBgeeprimitive streak1.00infobox
DDX3XBgeelacrimal gland1.00infobox
DDX3XBgeegenital tubercle1.00infobox
DDX3XBgeeepithelium of stomach1.00infobox
DDX3XBgeeureter1.00infobox
DDX3XBioGPSMore reference expression data1.00infobox
DDX3XChr.X chromosome (human)1.00infobox
DDX3XChr.X chromosome (mouse)1.00infobox
DDX3XDatabasesNCBI: entry; OMA: entry1.00infobox
DDX3XEnd41,364,472 bp1.00infobox

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