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Telomerase reverse transcriptase

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

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2.7.7.49
Aliases
TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BCK, 4B18, 4MNQ
Band
5p15.33 · 13 C1|13 40.12 cM
Bgee
stromal cell of endometrium · thymus · cardia · tongue · vein
BioGPS
More reference expression data

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Function

Regulation

Stem cells

Clinical significance

Medical implications

Interactions

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Telomerase reverse transcriptase

Nodes153
Edges152
Triples176
Avg. degree1.99
Density0.013072
Components1

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Telomerase reverse transcriptase

Top relations

Gene ontology · 74
Telomerase reverse transcriptase → beta-catenin-TCF complex assembly, cellular response to hypoxia, chaperone binding, chromosome, cytoplasm, cytosol, DNA binding, DNA biosynthetic process, DNA strand elongation, establishment of protein localization to telomere, identical protein binding, metal ion binding, mitochondrial nucleoid, mitochondrion, mitochondrion organization, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gene expression
Bgee · 20
Telomerase reverse transcriptase → cardia, condyle, epithelium of small intestine, external globus pallidus, fossa, genital tubercle, medullary collecting duct, mucosa of pharynx, otic vesicle, Paneth cell, pars reticulata, primary oocyte, pylorus, secondary oocyte, stromal cell of endometrium, superior surface of tongue, tail of embryo, thymus, tongue, vein
RNA expression pattern · 20
Telomerase reverse transcriptase → cardia, condyle, epithelium of small intestine, external globus pallidus, fossa, genital tubercle, medullary collecting duct, mucosa of pharynx, otic vesicle, Paneth cell, pars reticulata, primary oocyte, pylorus, secondary oocyte, stromal cell of endometrium, superior surface of tongue, tail of embryo, thymus, tongue, vein
related to Interactions · 8
Telomerase reverse transcriptase → HSP90AA1, Ku70, Ku80, MCRS1, Nucleolin, PAWR, PINX1, Telomerase
related to Function · 7
Telomerase reverse transcriptase → Alternative, Alternatively, RNA, Studies, Telomerase, The, TTAGGG
Band · 2
Telomerase reverse transcriptase → 13 C1|13 40.12 cM, 5p15.33
Chr. · 2
Telomerase reverse transcriptase → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Telomerase reverse transcriptase → 1,295,068 bp, 73,797,962 bp
2.7.7.49 · 1
Telomerase reverse transcriptase → ↗
Aliases · 1
Telomerase reverse transcriptase → TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT

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Important terminology

cells telomerase htert stem gene tert cancer activity telomeres cell telomere human ips rna also expression associated somatic promoter apoptosis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Telomerase reverse transcriptase2.7.7.491.00infobox
Telomerase reverse transcriptaseAliasesTERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT1.00infobox
Telomerase reverse transcriptaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BCK, 4B18, 4MNQ1.00infobox
Telomerase reverse transcriptaseBand5p15.331.00infobox
Telomerase reverse transcriptaseBand13 C1|13 40.12 cM1.00infobox
Telomerase reverse transcriptaseBgeestromal cell of endometrium1.00infobox
Telomerase reverse transcriptaseBgeethymus1.00infobox
Telomerase reverse transcriptaseBgeecardia1.00infobox
Telomerase reverse transcriptaseBgeetongue1.00infobox
Telomerase reverse transcriptaseBgeevein1.00infobox
Telomerase reverse transcriptaseBgeemucosa of pharynx1.00infobox
Telomerase reverse transcriptaseBgeeexternal globus pallidus1.00infobox
Telomerase reverse transcriptaseBgeepylorus1.00infobox
Telomerase reverse transcriptaseBgeesuperior surface of tongue1.00infobox
Telomerase reverse transcriptaseBgeepars reticulata1.00infobox
Telomerase reverse transcriptaseBgeePaneth cell1.00infobox
Telomerase reverse transcriptaseBgeeprimary oocyte1.00infobox
Telomerase reverse transcriptaseBgeeepithelium of small intestine1.00infobox
Telomerase reverse transcriptaseBgeesecondary oocyte1.00infobox
Telomerase reverse transcriptaseBgeemedullary collecting duct1.00infobox
Telomerase reverse transcriptaseBgeetail of embryo1.00infobox
Telomerase reverse transcriptaseBgeecondyle1.00infobox
Telomerase reverse transcriptaseBgeefossa1.00infobox
Telomerase reverse transcriptaseBgeegenital tubercle1.00infobox
Telomerase reverse transcriptaseBgeeotic vesicle1.00infobox
Telomerase reverse transcriptaseBioGPSMore reference expression data1.00infobox
Telomerase reverse transcriptaseChr.Chromosome 5 (human)1.00infobox
Telomerase reverse transcriptaseChr.Chromosome 13 (mouse)1.00infobox
Telomerase reverse transcriptaseDatabasesNCBI: entry; OMA: entry1.00infobox
Telomerase reverse transcriptaseEnd1,295,068 bp1.00infobox

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