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HIF1A

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.

Measurement, Function & Regulation

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Aliases
HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J
Band
14q23.2 · 12 C3|12 31.99 cM
Bgee
pancreatic ductal cell · corpus epididymis · caput epididymis · tibia · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)

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Overview

Structure

Gene and expression

Function

Regulation

Role in cancer

Role in Stroke

Role in Fetal Development

Interactions

Role in Fish

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Map overview Semantic statistics

HIF1A

Nodes162
Edges161
Triples299
Avg. degree1.99
Density0.012346
Components1

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HIF1A

Top relations

Gene ontology · 125
HIF1A → angiogenesis, axon cytoplasm, axonal transport of mitochondrion, B-1 B cell homeostasis, blood vessel development, blood vessel morphogenesis, camera-type eye morphogenesis, cardiac ventricle morphogenesis, cartilage development, cell differentiation, cellular iron ion homeostasis, cellular response to hypoxia, cellular response to interleukin-1, cerebral cortex development, collagen metabolic process, connective tissue replacement involved in inflammatory response wound healing, cytokine-mediated signaling pathway, cytoplasm, cytosol, digestive tract morphogenesis
related to Function · 21
HIF1A → Enzymes, Function, HIF, HIF-1, HIF1B, Hippel-Lindau, HPH, HRE, In, Many, ODD, Once, P402, P564, PHD, The, This, Under, VEGF, VHL
Bgee · 20
HIF1A → abdominal wall, calvaria, caput epididymis, cartilage tissue, corpus epididymis, cumulus cell, epithelium of lens, epithelium of nasopharynx, gingival epithelium, Gonadal ridge, iris, pancreatic ductal cell, pineal gland, retina, seminal vesicula, stria vascularis, tail of epididymis, tibia, vestibular sensory epithelium, visceral pleura
RNA expression pattern · 20
HIF1A → abdominal wall, calvaria, caput epididymis, cartilage tissue, corpus epididymis, cumulus cell, epithelium of lens, epithelium of nasopharynx, gingival epithelium, Gonadal ridge, iris, pancreatic ductal cell, pineal gland, retina, seminal vesicula, stria vascularis, tail of epididymis, tibia, vestibular sensory epithelium, visceral pleura
related to Repair, regeneration and rejuvenation · 15
HIF1A → Additionally, Following, HIF, HIF-1A, In, In June, Medicine, Not, One, PHD, PHDs, Researchers, Stanford University School, The, VEGFA
related to Interactions · 14
HIF1A → ARNT, ARNTL, CREBB, EP300, GR, HIF1AN, Mdm2, NR3C1, NR4A, P53, PSMA7, STAT3, UBC, VH
related to Role in cancer · 12
HIF1A → Clinically, Elevated HIF1A, However, Hypoxia, In, LV-positive, Moreover, Significant HIF1A, Similar, Studies, This, VEGF
related to Structure · 12
HIF1A → Arnt, C-terminal, CTAD, HIF1, ID, NTAD, PAC, PAS, PAS-associated C-terminal, PER-ARNT-SIM, The HIF1A, There
related to Gene and expression · 7
HIF1A → GC-rich, HIF-1-alpha, HIF1, In, Its, The, Typically
related to Regulation · 6
HIF1A → DFO, HBO, Hyperbaric, In, NF-κB-dependent, PHDs

Important terminology Word statistics

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Important terminology

hif-1α hypoxia oxygen also expression may fish cell levels tumor gene angiogenesis protein hif-1a transcription hypoxic factor metabolism conditions genes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HIF1AAliasesHIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α1.00infobox
HIF1AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J1.00infobox
HIF1ABand14q23.21.00infobox
HIF1ABand12 C3|12 31.99 cM1.00infobox
HIF1ABgeepancreatic ductal cell1.00infobox
HIF1ABgeecorpus epididymis1.00infobox
HIF1ABgeecaput epididymis1.00infobox
HIF1ABgeetibia1.00infobox
HIF1ABgeecartilage tissue1.00infobox
HIF1ABgeegingival epithelium1.00infobox
HIF1ABgeevisceral pleura1.00infobox
HIF1ABgeetail of epididymis1.00infobox
HIF1ABgeeseminal vesicula1.00infobox
HIF1ABgeeepithelium of nasopharynx1.00infobox
HIF1ABgeepineal gland1.00infobox
HIF1ABgeeretina1.00infobox
HIF1ABgeestria vascularis1.00infobox
HIF1ABgeecumulus cell1.00infobox
HIF1ABgeeepithelium of lens1.00infobox
HIF1ABgeeiris1.00infobox
HIF1ABgeeGonadal ridge1.00infobox
HIF1ABgeecalvaria1.00infobox
HIF1ABgeeabdominal wall1.00infobox
HIF1ABgeevestibular sensory epithelium1.00infobox
HIF1ABioGPSMore reference expression data1.00infobox
HIF1AChr.Chromosome 14 (human)1.00infobox
HIF1AChr.Chromosome 12 (mouse)1.00infobox
HIF1ADatabasesNCBI: entry; OMA: entry1.00infobox
HIF1AEnd61,748,259 bp1.00infobox
HIF1AEnd73,994,304 bp1.00infobox

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