Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

MBD4

Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.

Function, Clinical significance in cancer & Structure

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around MBD4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Function

23 related topics

Clinical significance in cancer

14 related topics

Structure

5 related topics

Interactions

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MBD4, MED1, methyl-CpG binding domain 4, DNA glycosylase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MOE, 3IHO, 4DK9, 4E9E, 4E9F, 4E9G, 4E9H, 4EA4, 4EA5, 4LG7, 4OFA, 4OFE, 4OFH, 5CHZ
Band
3q21.3 · 6 E3|6 53.72 cM
Bgee
secondary oocyte · pylorus · visceral pleura · trabecular bone · caput epididymis
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 6 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

MBD4

Nodes52
Edges51
Triples141
Avg. degree1.96
Density0.038462
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

MBD4

Top relations

Bgee · 20
MBD4 → caput epididymis, cardia, corpus epididymis, ejaculatory duct, embryo, epiblast, epithelium of male urethra, epithelium of nasopharynx, genital tubercle, lumbar spinal ganglion, optic nerve, pelvic part of vagina, pylorus, renal medulla, Rostral migratory stream, secondary oocyte, tail of embryo, trabecular bone, vagina, visceral pleura
RNA expression pattern · 20
MBD4 → caput epididymis, cardia, corpus epididymis, ejaculatory duct, embryo, epiblast, epithelium of male urethra, epithelium of nasopharynx, genital tubercle, lumbar spinal ganglion, optic nerve, pelvic part of vagina, pylorus, renal medulla, Rostral migratory stream, secondary oocyte, tail of embryo, trabecular bone, vagina, visceral pleura
Gene ontology · 17
MBD4 → catalytic activity, cellular response to DNA damage stimulus, chromatin, depyrimidination, DNA binding, DNA N-glycosylase activity, DNA repair, endodeoxyribonuclease activity, hydrolase activity, nuclear speck, nucleoplasm, nucleus, protein binding, pyrimidine-specific mismatch base pair DNA N-glycosylase activity, response to estradiol, response to radiation, satellite DNA binding
related to Function · 13
MBD4 → CpG-binding, DNA, Each, Further, Human, In, MBD, MBD1, MBD2, MBD3, MECP2, MIS, MSI
related to Deaminated bases as targets · 9
MBD4 → Bases, CpG, Deamination, DNA, However, Hypoxanthine, Notably, The, Upon DNA
related to Mutational importance of targets · 9
MBD4 → About, Alternatively, CpG, DNA, For, MMR-defective, Mutations, The, These
related to Somatic mutations of MBD4 · 8
MBD4 → DNA, In, MLH1, MMR, Msh2, Msh6, Mutation, Pms2
related to Structure · 7
MBD4 → C-terminal DNA, CpG-binding, E3, Human MBD4, These, UHRF1, USP7
related to Germline mutations of MBD4 · 6
MBD4 → An MBD4, CpG, Israeli Christian Arabs, Mono, These, This
related to Epigenetic silencing · 5
MBD4 → DNA, MGMT, MLH1, This, While

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mutations dna human gene deamination bp protein chr band repair cpg cancers chromosome domain mlh1 function colorectal cancer expression base

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MBD4AliasesMBD4, MED1, methyl-CpG binding domain 4, DNA glycosylase1.00infobox
MBD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2MOE, 3IHO, 4DK9, 4E9E, 4E9F, 4E9G, 4E9H, 4EA4, 4EA5, 4LG7, 4OFA, 4OFE, 4OFH, 5CHZ1.00infobox
MBD4Band3q21.31.00infobox
MBD4Band6 E3|6 53.72 cM1.00infobox
MBD4Bgeesecondary oocyte1.00infobox
MBD4Bgeepylorus1.00infobox
MBD4Bgeevisceral pleura1.00infobox
MBD4Bgeetrabecular bone1.00infobox
MBD4Bgeecaput epididymis1.00infobox
MBD4Bgeeepithelium of nasopharynx1.00infobox
MBD4Bgeeoptic nerve1.00infobox
MBD4Bgeecardia1.00infobox
MBD4Bgeerenal medulla1.00infobox
MBD4Bgeecorpus epididymis1.00infobox
MBD4Bgeelumbar spinal ganglion1.00infobox
MBD4Bgeeepithelium of male urethra1.00infobox
MBD4Bgeegenital tubercle1.00infobox
MBD4Bgeetail of embryo1.00infobox
MBD4Bgeevagina1.00infobox
MBD4BgeeRostral migratory stream1.00infobox
MBD4Bgeeejaculatory duct1.00infobox
MBD4Bgeepelvic part of vagina1.00infobox
MBD4Bgeeepiblast1.00infobox
MBD4Bgeeembryo1.00infobox
MBD4BioGPSMore reference expression data1.00infobox
MBD4Chr.Chromosome 3 (human)1.00infobox
MBD4Chr.Chromosome 6 (mouse)1.00infobox
MBD4DatabasesNCBI: entry; OMA: entry1.00infobox
MBD4End129,440,179 bp1.00infobox
MBD4End115,830,332 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.