ABCA1

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ABCA1 topic overview

The analysis highlights Physiological role, Interactions and Clinical significance as prominent areas in the source structure around ABCA1.

Related topics: 42
Source areas: 6
Connected nodes: 48
Extracted relationships: 198
Concept neighborhoods: 15
Bridge connections: 48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Physiological role · 23 topics

Interactions · 6 topics

Overview · 5 topics

Clinical significance · 4 topics

Function · 3 topics

Tangier disease · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.6.2.1: ↗
Aliases: ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP1
Band: 9q31.1 · 4 B2|4 28.57 cM
Bgee: skin of hip · left adrenal gland · left adrenal cortex · right adrenal gland · skin of thigh
BioGPS: More reference expression data
Chr.: Chromosome 9 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tangier disease

Tangier disease Tangier's Disease

Function

ATP-binding cassette (ABC) transporters ATP-binding cassette transporter
Efflux Efflux (microbiology)
PDZ domain

Physiological role

Apolipoproteins Apolipoprotein
Reverse cholesterol transport
High-density lipoproteins High-density lipoprotein
Cell membrane
Expressed Biosynthesis
KDa Dalton (unit)
Posttranslational modification
Fatty acids Fatty acid
Cytokines Cytokine
CAMP Cyclic adenosine monophosphate
Adiponectin
Metabolites Metabolite
Glucose
Bilirubin
JAK-STAT JAK-STAT signaling pathway
PKA Protein Kinase A
PKC Protein Kinase C
Diarylheptanoid
Antioxidant
Curcumin
Atherogenesis
AMD Age-related macular degeneration
Angiogenesis

Clinical significance

Tangier disease
Hormone replacement therapy (HRT) Hormone replacement therapy (menopause)
Astroctytes Astrocyte
Glioblastoma

Interactions

Interact Protein-protein interaction
APOA1 Apolipoprotein A1
APOE Apolipoprotein E
FADD
SNTB2
XPC XPC (gene)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ABCA1 connects Entity context

The extracted context around ABCA1 shows recurring relationship patterns in the source. For example, ABCA1 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, anion transmembrane transport, anion transmembrane transporter activity, apolipoprotein A-I binding, apolipoprotein A-I receptor activity, apolipoprotein A-I-mediated signaling pathway, apolipoprotein binding, ATP binding, ATPase activity, ATPase binding, ATPase-coupled transmembrane transporter activity, cell surface, cellular response to cholesterol, cellular response to lipopolysaccharide, cellular response to low-density lipoprotein particle stimulus, cellular response to retinoic acid, cholesterol binding, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process Another extracted example is ABCA1 → ciliary body, decidua, endothelial cell of lymphatic vessel, epithelium of colon, gastrula, left adrenal cortex, left adrenal gland, left lobe of liver, left lung lobe, liver, lower lobe of lung, right adrenal cortex, right adrenal gland, skin of external ear, skin of hip, skin of thigh, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, transitional epithelium of urinary bladder. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 76

ABCA1 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, anion transmembrane transport, anion transmembrane transporter activity, apolipoprotein A-I binding, apolipoprotein A-I receptor activity, apolipoprotein A-I-mediated signaling pathway, apolipoprotein binding, ATP binding, ATPase activity, ATPase binding, ATPase-coupled transmembrane transporter activity, cell surface, cellular response to cholesterol, cellular response to lipopolysaccharide, cellular response to low-density lipoprotein particle stimulus, cellular response to retinoic acid, cholesterol binding, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process

Bgee · 20

ABCA1 → ciliary body, decidua, endothelial cell of lymphatic vessel, epithelium of colon, gastrula, left adrenal cortex, left adrenal gland, left lobe of liver, left lung lobe, liver, lower lobe of lung, right adrenal cortex, right adrenal gland, skin of external ear, skin of hip, skin of thigh, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, transitional epithelium of urinary bladder

RNA expression pattern · 20

related to Function · 17

ABCA1 → ABC, ABCA, ALD, ATP-binding, GCN20, MDR/TAP, Members, MRP, OABP, PDZ, The, The ABCA1, This, VFVNFA, While, White, With

related to Tangier disease · 16

ABCA1 → American Heart Association, British Columbia, CA, CV Therapeutics, DNA, Gerd Schmitz's, Germany, It, Michael Hayden's, Palo Alto, Richard Lawn's, Subsequent, Tangier, Tangier's, They, This

related to Physiological role · 8

ABCA1 → ABCA1-dependent, Adiponectin, Factors, Golgi, HDL, It, Other, Since

related to Clinical significance · 5

ABCA1 → HDL, HRT, Leukocytes' ABCA1, Mutations, Tangier

related to Interactions · 4

ABCA1 → APOA1, APOE, FADD, SNTB2

Band · 2

ABCA1 → 4 B2|4 28.57 cM, 9q31.1

Chr. · 2

ABCA1 → Chromosome 4 (mouse), Chromosome 9 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cholesterol human bp protein disease efflux also transporter chr band expression chromosome tangier mouse transport atp-binding cassette member location

ABCA1 relationships Subject–Predicate–Object triples

TTTA extracted 198 structured relationships around ABCA1. Examples in this analysis include ABCA1 → 7.6.2.1 → ↗ and ABCA1 → Aliases → ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
ABCA1	7.6.2.1	↗	1.00	infobox
ABCA1	Aliases	ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP1	1.00	infobox
ABCA1	Band	9q31.1	1.00	infobox
ABCA1	Band	4 B2\|4 28.57 cM	1.00	infobox
ABCA1	Bgee	skin of hip	1.00	infobox
ABCA1	Bgee	left adrenal gland	1.00	infobox
ABCA1	Bgee	left adrenal cortex	1.00	infobox
ABCA1	Bgee	right adrenal gland	1.00	infobox
ABCA1	Bgee	skin of thigh	1.00	infobox
ABCA1	Bgee	right adrenal cortex	1.00	infobox
ABCA1	Bgee	epithelium of colon	1.00	infobox
ABCA1	Bgee	stromal cell of endometrium	1.00	infobox
ABCA1	Bgee	lower lobe of lung	1.00	infobox
ABCA1	Bgee	liver	1.00	infobox
ABCA1	Bgee	stroma of bone marrow	1.00	infobox
ABCA1	Bgee	subcutaneous adipose tissue	1.00	infobox
ABCA1	Bgee	skin of external ear	1.00	infobox
ABCA1	Bgee	left lung lobe	1.00	infobox
ABCA1	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
ABCA1	Bgee	transitional epithelium of urinary bladder	1.00	infobox
ABCA1	Bgee	gastrula	1.00	infobox
ABCA1	Bgee	decidua	1.00	infobox
ABCA1	Bgee	left lobe of liver	1.00	infobox
ABCA1	Bgee	ciliary body	1.00	infobox
ABCA1	BioGPS	More reference expression data	1.00	infobox
ABCA1	Chr.	Chromosome 9 (human)	1.00	infobox
ABCA1	Chr.	Chromosome 4 (mouse)	1.00	infobox
ABCA1	Databases	NCBI: entry; OMA: entry	1.00	infobox
ABCA1	End	104,928,155 bp	1.00	infobox
ABCA1	End	53,159,895 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ABCA1 bring nearby vocabulary together. In this analysis, examples include Gene, Disease and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

ABCA1
- Gene
- Disease
- Also
- Expression
- Cholesterol
- Human
- Function
- Efflux
- Tangier
- Transporter
- Activity
- Interactions
abca1
- Gene
- Disease
- Also
- Expression
- Cholesterol
- Human
- Function
- Efflux
- Tangier
- Transporter
- Activity
- Interactions
protein
- Cellular
- Lipid
- Pathway
- Transporter
- Gene
- Cerp
- External
- Homeostasis
- Phospholipid
- Sub-family
- Activity
- High-density
gene
- Human
- Location
- Disease
- Ucsc
- Cell
- Chromosome
- Member
- Bp
- Chr
- Tangier
- Transporter
- Expression
cholesterol
- Efflux
- Cellular
- Reverse
- Function
- Pathway
- Transport
- Transporter
- Protein
- Homeostasis
- Phospholipid
- High-density
- Lipid
tangier disease
- Tangier
- Function
- Mouse
- External
- Gene
- Human
- Activity
- High-density
- Cell
- Chromosome
- Location
- Pathway
atp-binding cassette (abc) transporters
- Cassette
- Member
- Cerp
- Sub-family
- Abca
- Gene
- Human
- Location
- Transporter
- Also
- Protein
- External
efflux
- Lipid
- Protein
- Activity
- Cellular
- High-density
- Reverse
- Pathway
- Transport
- Transporter
- Human
- Cerp
- External

Connections between topic areas Semantic bridges

For ABCA1, one of the stronger structural bridges in this analysis connects ABCA1 with Physiological role. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

ABCA1 — Physiological role · splits 25 ⟂ 24

ABCA1 — Interactions · splits 42 ⟂ 7

ABCA1 — Overview · splits 43 ⟂ 6

ABCA1 — Clinical significance · splits 44 ⟂ 5

ABCA1 — Function · splits 45 ⟂ 4

Map overview Semantic statistics

ABCA1

Nodes49

Edges48

Triples198

Avg. degree1.96

Density0.040816

Components1

Source & methodology

TTTA analyzes the structure around ABCA1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Physiological role, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ABCA1 · EN edition · Analysis: TopicsToTalkAbout