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ABCA1

ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.

Physiological role, Interactions & Clinical significance

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7.6.2.1
Aliases
ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP1
Band
9q31.1 · 4 B2|4 28.57 cM
Bgee
skin of hip · left adrenal gland · left adrenal cortex · right adrenal gland · skin of thigh
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)

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Overview

Tangier disease

Function

Physiological role

Clinical significance

Interactions

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Map overview Semantic statistics

ABCA1

Nodes49
Edges48
Triples198
Avg. degree1.96
Density0.040816
Components1

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ABCA1

Top relations

Gene ontology · 76
ABCA1 → adenylate cyclase-activating G protein-coupled receptor signaling pathway, anion transmembrane transport, anion transmembrane transporter activity, apolipoprotein A-I binding, apolipoprotein A-I receptor activity, apolipoprotein A-I-mediated signaling pathway, apolipoprotein binding, ATP binding, ATPase activity, ATPase binding, ATPase-coupled transmembrane transporter activity, cell surface, cellular response to cholesterol, cellular response to lipopolysaccharide, cellular response to low-density lipoprotein particle stimulus, cellular response to retinoic acid, cholesterol binding, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process
Bgee · 20
ABCA1 → ciliary body, decidua, endothelial cell of lymphatic vessel, epithelium of colon, gastrula, left adrenal cortex, left adrenal gland, left lobe of liver, left lung lobe, liver, lower lobe of lung, right adrenal cortex, right adrenal gland, skin of external ear, skin of hip, skin of thigh, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, transitional epithelium of urinary bladder
RNA expression pattern · 20
ABCA1 → ciliary body, decidua, endothelial cell of lymphatic vessel, epithelium of colon, gastrula, left adrenal cortex, left adrenal gland, left lobe of liver, left lung lobe, liver, lower lobe of lung, right adrenal cortex, right adrenal gland, skin of external ear, skin of hip, skin of thigh, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, transitional epithelium of urinary bladder
related to Function · 17
ABCA1 → ABC, ABCA, ALD, ATP-binding, GCN20, MDR/TAP, Members, MRP, OABP, PDZ, The, The ABCA1, This, VFVNFA, While, White, With
related to Tangier disease · 16
ABCA1 → American Heart Association, British Columbia, CA, CV Therapeutics, DNA, Gerd Schmitz's, Germany, It, Michael Hayden's, Palo Alto, Richard Lawn's, Subsequent, Tangier, Tangier's, They, This
related to Physiological role · 8
ABCA1 → ABCA1-dependent, Adiponectin, Factors, Golgi, HDL, It, Other, Since
related to Clinical significance · 5
ABCA1 → HDL, HRT, Leukocytes' ABCA1, Mutations, Tangier
related to Interactions · 4
ABCA1 → APOA1, APOE, FADD, SNTB2
Band · 2
ABCA1 → 4 B2|4 28.57 cM, 9q31.1
Chr. · 2
ABCA1 → Chromosome 4 (mouse), Chromosome 9 (human)

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Important terminology

gene cholesterol human bp protein disease efflux also transporter chr band expression chromosome tangier mouse transport atp-binding cassette member location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ABCA17.6.2.11.00infobox
ABCA1AliasesABCA1, ATP-binding cassette, sub-family A (ABC1), member 1, Abca1, ABC-1, Abc1, ABC1, CERP, HDLDT1, TGD, ATP binding cassette subfamily A member 1, HDLCQTL13, HPALP11.00infobox
ABCA1Band9q31.11.00infobox
ABCA1Band4 B2|4 28.57 cM1.00infobox
ABCA1Bgeeskin of hip1.00infobox
ABCA1Bgeeleft adrenal gland1.00infobox
ABCA1Bgeeleft adrenal cortex1.00infobox
ABCA1Bgeeright adrenal gland1.00infobox
ABCA1Bgeeskin of thigh1.00infobox
ABCA1Bgeeright adrenal cortex1.00infobox
ABCA1Bgeeepithelium of colon1.00infobox
ABCA1Bgeestromal cell of endometrium1.00infobox
ABCA1Bgeelower lobe of lung1.00infobox
ABCA1Bgeeliver1.00infobox
ABCA1Bgeestroma of bone marrow1.00infobox
ABCA1Bgeesubcutaneous adipose tissue1.00infobox
ABCA1Bgeeskin of external ear1.00infobox
ABCA1Bgeeleft lung lobe1.00infobox
ABCA1Bgeeendothelial cell of lymphatic vessel1.00infobox
ABCA1Bgeetransitional epithelium of urinary bladder1.00infobox
ABCA1Bgeegastrula1.00infobox
ABCA1Bgeedecidua1.00infobox
ABCA1Bgeeleft lobe of liver1.00infobox
ABCA1Bgeeciliary body1.00infobox
ABCA1BioGPSMore reference expression data1.00infobox
ABCA1Chr.Chromosome 9 (human)1.00infobox
ABCA1Chr.Chromosome 4 (mouse)1.00infobox
ABCA1DatabasesNCBI: entry; OMA: entry1.00infobox
ABCA1End104,928,155 bp1.00infobox
ABCA1End53,159,895 bp1.00infobox

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