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DFFA

DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene.

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Aliases
DFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IBX, 1IYR, 1KOY
Band
1p36.22 · 4|4 E2
Bgee
internal globus pallidus · inferior ganglion of vagus nerve · nipple · cardia · ventral tegmental area
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Map overview Semantic statistics

DFFA

Nodes17
Edges16
Triples84
Avg. degree1.88
Density0.117647
Components1

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DFFA

Top relations

Bgee · 20
DFFA → cardia, cartilage tissue, inferior ganglion of vagus nerve, internal globus pallidus, islet of Langerhans, lip, medulla oblongata, muscle of thigh, nipple, pons, primary motor cortex, quadriceps femoris muscle, renal medulla, soleus muscle, stromal cell of endometrium, subthalamic nucleus, tibialis anterior muscle, ventral tegmental area, yolk sac, zone of skin
RNA expression pattern · 20
DFFA → cardia, cartilage tissue, inferior ganglion of vagus nerve, internal globus pallidus, islet of Langerhans, lip, medulla oblongata, muscle of thigh, nipple, pons, primary motor cortex, quadriceps femoris muscle, renal medulla, soleus muscle, stromal cell of endometrium, subthalamic nucleus, tibialis anterior muscle, ventral tegmental area, yolk sac, zone of skin
Gene ontology · 19
DFFA → apoptotic DNA fragmentation, apoptotic process, chaperone-mediated protein folding, cytoplasm, cytosol, deoxyribonuclease inhibitor activity, intracellular anatomical structure, lipid droplet, negative regulation of apoptotic DNA fragmentation, negative regulation of deoxyribonuclease activity, negative regulation of execution phase of apoptosis, nucleoplasm, nucleus, plasma membrane, positive regulation of apoptotic process, protein binding, protein domain specific binding, protein folding chaperone activity, thymocyte apoptotic process
Band · 2
DFFA → 1p36.22, 4|4 E2
Chr. · 2
DFFA → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
DFFA → 10,472,529 bp, 149,205,104 bp
Aliases · 1
DFFA → DFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha
Available structures · 1
DFFA → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IBX, 1IYR, 1KOY
BioGPS · 1
DFFA → More reference expression data
Databases · 1
DFFA → NCBI: entry; OMA: entry

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Important terminology

dna fragmentation dffb gene bp chr apoptosis process human band c-terminal protein apoptotic domain chromosome dff factor dnase location also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DFFAAliasesDFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha1.00infobox
DFFAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1IBX, 1IYR, 1KOY1.00infobox
DFFABand1p36.221.00infobox
DFFABand4|4 E21.00infobox
DFFABgeeinternal globus pallidus1.00infobox
DFFABgeeinferior ganglion of vagus nerve1.00infobox
DFFABgeenipple1.00infobox
DFFABgeecardia1.00infobox
DFFABgeeventral tegmental area1.00infobox
DFFABgeecartilage tissue1.00infobox
DFFABgeestromal cell of endometrium1.00infobox
DFFABgeerenal medulla1.00infobox
DFFABgeesubthalamic nucleus1.00infobox
DFFABgeeislet of Langerhans1.00infobox
DFFABgeesoleus muscle1.00infobox
DFFABgeeyolk sac1.00infobox
DFFABgeemedulla oblongata1.00infobox
DFFABgeelip1.00infobox
DFFABgeepons1.00infobox
DFFABgeequadriceps femoris muscle1.00infobox
DFFABgeezone of skin1.00infobox
DFFABgeemuscle of thigh1.00infobox
DFFABgeeprimary motor cortex1.00infobox
DFFABgeetibialis anterior muscle1.00infobox
DFFABioGPSMore reference expression data1.00infobox
DFFAChr.Chromosome 1 (human)1.00infobox
DFFAChr.Chromosome 4 (mouse)1.00infobox
DFFADatabasesNCBI: entry; OMA: entry1.00infobox
DFFAEnd10,472,529 bp1.00infobox
DFFAEnd149,205,104 bp1.00infobox

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