Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of three cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is expressed in inflammation.
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
Cyclooxygenase-2 topic overview
The analysis highlights History, Clinical significance and Structure as prominent areas in the source structure around Cyclooxygenase-2.
Related topics
99
Source areas
7
Connected nodes
106
Extracted relationships
173
Related term clusters
23
Bridge connections
106
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Clinical significance · 41 topics
Structure · 18 topics
Function · 16 topics
Mechanism · 12 topics
Overview · 8 topics
History · 2 topics
Interactions · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
You can skip this section if you’re here for content ideas and keyword inspiration.
Advanced semantic analysis
How Cyclooxygenase-2 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Cyclooxygenase-2 shows recurring relationship patterns in the source. For example, Cyclooxygenase-2 → ageing, angiogenesis, arachidonate 15-lipoxygenase activity, bone mineralization, brown fat cell differentiation, caveola, cellular oxidant detoxification, cellular response to ATP, cellular response to fluid shear stress, cellular response to heat, cellular response to hypoxia, cellular response to lead ion, cellular response to mechanical stimulus, cellular response to non-ionic osmotic stress, cellular response to UV, cyclooxygenase pathway, cytokine-mediated signaling pathway, cytoplasm, decidualization, dioxygenase activity Another extracted example is Cyclooxygenase-2 → beta cell, calvaria, cartilage tissue, cumulus cell, decidua, dentate gyrus, endothelial cell of lymphatic vessel, gallbladder, gastrula, granulocyte, mucosa of paranasal sinus, mucosa of urinary bladder, periodontal fiber, right lung lobe, saphenous vein, seminal vesicula, stroma of bone marrow, subdivision of hippocampus, vena cava, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.
Cyclooxygenase-2
Top relations
Gene ontology· 101
Cyclooxygenase-2 → ageing, angiogenesis, arachidonate 15-lipoxygenase activity, bone mineralization, brown fat cell differentiation, caveola, cellular oxidant detoxification, cellular response to ATP, cellular response to fluid shear stress, cellular response to heat, cellular response to hypoxia, cellular response to lead ion, cellular response to mechanical stimulus, cellular response to non-ionic osmotic stress, cellular response to UV, cyclooxygenase pathway, cytokine-mediated signaling pathway, cytoplasm, decidualization, dioxygenase activity
Bgee· 20
Cyclooxygenase-2 → beta cell, calvaria, cartilage tissue, cumulus cell, decidua, dentate gyrus, endothelial cell of lymphatic vessel, gallbladder, gastrula, granulocyte, mucosa of paranasal sinus, mucosa of urinary bladder, periodontal fiber, right lung lobe, saphenous vein, seminal vesicula, stroma of bone marrow, subdivision of hippocampus, vena cava, visceral pleura
RNA expression pattern· 20
Cyclooxygenase-2 → beta cell, calvaria, cartilage tissue, cumulus cell, decidua, dentate gyrus, endothelial cell of lymphatic vessel, gallbladder, gastrula, granulocyte, mucosa of paranasal sinus, mucosa of urinary bladder, periodontal fiber, right lung lobe, saphenous vein, seminal vesicula, stroma of bone marrow, subdivision of hippocampus, vena cava, visceral pleura
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 173 structured relationships around Cyclooxygenase-2. Examples in this analysis include Cyclooxygenase-2 → 1.14.99.1 → ↗ and Cyclooxygenase-2 → Aliases → PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
1.00
infobox
Cyclooxygenase-2
Band
1q31.1
1.00
infobox
Cyclooxygenase-2
Band
1 G1|1 63.84 cM
1.00
infobox
Cyclooxygenase-2
Bgee
seminal vesicula
1.00
infobox
Cyclooxygenase-2
Bgee
cartilage tissue
1.00
infobox
Cyclooxygenase-2
Bgee
mucosa of urinary bladder
1.00
infobox
Cyclooxygenase-2
Bgee
beta cell
1.00
infobox
Cyclooxygenase-2
Bgee
periodontal fiber
1.00
infobox
Cyclooxygenase-2
Bgee
vena cava
1.00
infobox
Cyclooxygenase-2
Bgee
visceral pleura
1.00
infobox
Cyclooxygenase-2
Bgee
saphenous vein
1.00
infobox
Cyclooxygenase-2
Bgee
mucosa of paranasal sinus
1.00
infobox
Cyclooxygenase-2
Bgee
gallbladder
1.00
infobox
Cyclooxygenase-2
Bgee
granulocyte
1.00
infobox
Cyclooxygenase-2
Bgee
decidua
1.00
infobox
Cyclooxygenase-2
Bgee
gastrula
1.00
infobox
Cyclooxygenase-2
Bgee
stroma of bone marrow
1.00
infobox
Cyclooxygenase-2
Bgee
dentate gyrus
1.00
infobox
Cyclooxygenase-2
Bgee
cumulus cell
1.00
infobox
Cyclooxygenase-2
Bgee
endothelial cell of lymphatic vessel
1.00
infobox
Cyclooxygenase-2
Bgee
right lung lobe
1.00
infobox
Cyclooxygenase-2
Bgee
calvaria
1.00
infobox
Cyclooxygenase-2
Bgee
subdivision of hippocampus
1.00
infobox
Cyclooxygenase-2
BioGPS
More reference expression data
1.00
infobox
Cyclooxygenase-2
Chr.
Chromosome 1 (human)
1.00
infobox
Cyclooxygenase-2
Chr.
Chromosome 1 (mouse)
1.00
infobox
Cyclooxygenase-2
Databases
NCBI: entry; OMA: entry
1.00
infobox
Cyclooxygenase-2
End
186,680,922 bp
1.00
infobox
No triples extracted yet.
Related concept clusters Related term clusters
Related term clusters group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Cyclooxygenase-2 bring nearby vocabulary together. In this analysis, examples include Synthase, Gene and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
arachidonic acid
Arachidonic
Fatty
Pgg2
Expressed
E-allo
Inhibitors
Cox-2
Prostaglandin
Two
E-cat
Also
Cox
fatty acid
Arachidonic
Fatty
Cox
Inhibitors
Ptgs
Pgg2
E-allo
Cox-2
Expressed
E-cat
Also
Prostaglandin
selective cox-2 inhibitors
Ptgs2
Cox
Ptgs
Cardiovascular
Nsaids
Site
E-cat
E-allo
Human
Arachidonic
Expression
Synthase
enzyme
Synthase
Gene
Chromosome
Bp
Chr
Peroxidase
Human
Band
Expressed
Site
Active
Fatty
gene
Chromosome
Synthase
Human
Bp
Chr
Band
Presence
Prostaglandin
Ptgs2
Cells
Expression
Expressed
active site
Peroxidase
Cox
Active
Site
Inhibitors
Ptgs
Two
Enzyme
E-cat
E-allo
Fatty
Pgg2
decidual cells
Inflammation
Expression
Presence
Found
Gene
Prostaglandins
Ptgs2
Cox-2
Cardiovascular
Expressed
Fatty
Prostaglandin
myometrial cells
Inflammation
Expression
Presence
Found
Gene
Prostaglandins
Ptgs2
Cox-2
Cardiovascular
Expressed
Fatty
Prostaglandin
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Cyclooxygenase-2, one of the stronger structural bridges in this analysis connects Cyclooxygenase-2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Cyclooxygenase-2
Nodes107
Edges106
Triples173
Avg. degree1.98
Density0.018692
Components1
Source & methodology
TTTA analyzes the structure around Cyclooxygenase-2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
