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Cytochrome c oxidase subunit 2: Measurement, Clinical significance & Structure

Cytochrome c oxidase II is a protein in eukaryotes that is encoded by the MT-CO2 gene. Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV.

Language: English [EN]
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Cytochrome c oxidase subunit 2 topic overview

The analysis highlights Measurement, Clinical significance and Structure as prominent areas in the source structure around Cytochrome c oxidase subunit 2.

Related topics
72
Source areas
5
Connected nodes
77
Extracted relationships
102
Related term clusters
20
Bridge connections
77

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 38 topics
Structure · 18 topics
Overview · 8 topics
Function · 6 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.1.1.9
↗
Aliases
COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3VRJ
Band
n/a
Bgee
mucosa of transverse colon · putamen · caudate nucleus · right frontal lobe · nucleus accumbens
BioGPS
n/a

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

For the semantics nerds

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Advanced semantic analysis

How Cytochrome c oxidase subunit 2 connects Entity context

The extracted context around Cytochrome c oxidase subunit 2 shows recurring relationship patterns in the source. For example, Cytochrome c oxidase subunit 2 → ATP synthesis coupled electron transport, copper ion binding, cytochrome-c oxidase activity, electron transport chain, extracellular exosome, integral component of membrane, lactation, membrane, metal ion binding, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion, oxidoreductase activity, positive regulation of ATP biosynthetic process, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of necrotic cell death, protein binding, proton transmembrane transport, respirasome Another extracted example is Cytochrome c oxidase subunit 2 → caudate nucleus, dentate gyrus of hippocampal formation granule cell, duodenum, epiblast, esophagus, hippocampus proper, hypothalamus, jejunum, mucosa of transverse colon, muscle layer of sigmoid colon, nucleus accumbens, ovary, proximal tubule, putamen, right frontal lobe, right hemisphere of cerebellum, right kidney, substantia nigra, ventricular zone, zone of skin. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cytochrome c oxidase subunit 2

Top relations

Gene ontology · 22
Cytochrome c oxidase subunit 2 → ATP synthesis coupled electron transport, copper ion binding, cytochrome-c oxidase activity, electron transport chain, extracellular exosome, integral component of membrane, lactation, membrane, metal ion binding, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion, oxidoreductase activity, positive regulation of ATP biosynthetic process, positive regulation of hydrogen peroxide biosynthetic process, positive regulation of necrotic cell death, protein binding, proton transmembrane transport, respirasome
Bgee · 20
Cytochrome c oxidase subunit 2 → caudate nucleus, dentate gyrus of hippocampal formation granule cell, duodenum, epiblast, esophagus, hippocampus proper, hypothalamus, jejunum, mucosa of transverse colon, muscle layer of sigmoid colon, nucleus accumbens, ovary, proximal tubule, putamen, right frontal lobe, right hemisphere of cerebellum, right kidney, substantia nigra, ventricular zone, zone of skin
RNA expression pattern · 20
Cytochrome c oxidase subunit 2 → caudate nucleus, dentate gyrus of hippocampal formation granule cell, duodenum, epiblast, esophagus, hippocampus proper, hypothalamus, jejunum, mucosa of transverse colon, muscle layer of sigmoid colon, nucleus accumbens, ovary, proximal tubule, putamen, right frontal lobe, right hemisphere of cerebellum, right kidney, substantia nigra, ventricular zone, zone of skin
Chr. · 2
Cytochrome c oxidase subunit 2 → Mitochondrial DNA (human), Mitochondrial DNA (mouse)
End · 2
Cytochrome c oxidase subunit 2 → 7,696 bp, 8,269 bp
7.1.1.9 · 1
Cytochrome c oxidase subunit 2 → ↗
Aliases · 1
Cytochrome c oxidase subunit 2 → COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
Available structures · 1
Cytochrome c oxidase subunit 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3VRJ
Band · 1
Cytochrome c oxidase subunit 2 → n/a
BioGPS · 1
Cytochrome c oxidase subunit 2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mt-co2 mitochondrial cytochrome gene complex oxidase iv dna bp chr human band enzyme subunit respiratory protein deficiency ii encoded oxygen

Cytochrome c oxidase subunit 2 relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Cytochrome c oxidase subunit 2. Examples in this analysis include Cytochrome c oxidase subunit 2 → 7.1.1.9 → ↗ and Cytochrome c oxidase subunit 2 → Aliases → COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cytochrome c oxidase subunit 27.1.1.9↗1.00infobox
Cytochrome c oxidase subunit 2AliasesCOX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II1.00infobox
Cytochrome c oxidase subunit 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3VRJ1.00infobox
Cytochrome c oxidase subunit 2Bandn/a1.00infobox
Cytochrome c oxidase subunit 2Bgeemucosa of transverse colon1.00infobox
Cytochrome c oxidase subunit 2Bgeeputamen1.00infobox
Cytochrome c oxidase subunit 2Bgeecaudate nucleus1.00infobox
Cytochrome c oxidase subunit 2Bgeeright frontal lobe1.00infobox
Cytochrome c oxidase subunit 2Bgeenucleus accumbens1.00infobox
Cytochrome c oxidase subunit 2Bgeeright hemisphere of cerebellum1.00infobox
Cytochrome c oxidase subunit 2Bgeehippocampus proper1.00infobox
Cytochrome c oxidase subunit 2Bgeesubstantia nigra1.00infobox
Cytochrome c oxidase subunit 2Bgeemuscle layer of sigmoid colon1.00infobox
Cytochrome c oxidase subunit 2Bgeehypothalamus1.00infobox
Cytochrome c oxidase subunit 2Bgeeventricular zone1.00infobox
Cytochrome c oxidase subunit 2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Cytochrome c oxidase subunit 2Bgeeesophagus1.00infobox
Cytochrome c oxidase subunit 2Bgeezone of skin1.00infobox
Cytochrome c oxidase subunit 2Bgeeovary1.00infobox
Cytochrome c oxidase subunit 2Bgeeepiblast1.00infobox
Cytochrome c oxidase subunit 2Bgeejejunum1.00infobox
Cytochrome c oxidase subunit 2Bgeeright kidney1.00infobox
Cytochrome c oxidase subunit 2Bgeeproximal tubule1.00infobox
Cytochrome c oxidase subunit 2Bgeeduodenum1.00infobox
Cytochrome c oxidase subunit 2BioGPSn/a1.00infobox
Cytochrome c oxidase subunit 2Chr.Mitochondrial DNA (human)1.00infobox
Cytochrome c oxidase subunit 2Chr.Mitochondrial DNA (mouse)1.00infobox
Cytochrome c oxidase subunit 2DatabasesNCBI: entry; OMA: entry1.00infobox
Cytochrome c oxidase subunit 2End8,269 bp1.00infobox
Cytochrome c oxidase subunit 2End7,696 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Cytochrome c oxidase subunit 2 bring nearby vocabulary together. In this analysis, examples include Oxidase, Mt-co2 and Cytochrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cytochrome c oxidase subunit 2
    • Oxidase
    • Mt-co2
    • Cytochrome
    • Subunit
    • Iv
    • Chain
    • Oxygen
    • Complex
    • Respiratory
    • Mitochondrial
    • Ii
    • Copper
  • cytochrome c oxidase subunit 2
    • Oxidase
    • Mt-co2
    • Coii
    • Cox2
    • Cytochrome
    • Subunit
    • Ii
    • Iv
    • Chain
    • Oxygen
    • Complex
    • Respiratory
  • gene
    • Mt-co2
    • Mitochondrial
    • Iv
    • Location
    • Complex
    • Human
    • Protein
    • Oxidase
    • Bp
    • Chr
    • Dna
    • Function
  • cytochrome c oxidase
    • Oxidase
    • Mt-co2
    • Subunit
    • Iv
    • Chain
    • Oxygen
    • Complex
    • Respiratory
    • Mitochondrial
    • Gene
    • Ii
    • Copper
  • mitochondrial dna
    • Human
    • Bp
    • Chr
    • Complex
    • Iv
    • Location
    • Band
    • Dna
    • Mitochondrial
    • Respiratory
    • Function
    • Mouse
  • respiratory complex iv
    • Chain
    • Oxygen
    • Iv
    • Respiratory
    • Mitochondrial
    • Enzyme
    • Deficiency
    • Subunit
    • Mt-co2
    • Oxidase
    • Cytochrome
    • Function
  • complex
    • Iv
    • Mitochondrial
    • Enzyme
    • Respiratory
    • Chain
    • Oxygen
    • Cytochrome
    • Mt-co2
    • Deficiency
    • Dna
    • Subunit
    • Oxidase
  • mitochondrial respiratory chain
    • Oxygen
    • Chain
    • Respiratory
    • Complex
    • Iv
    • Dna
    • Human
    • Mitochondrial
    • Bp
    • Chr
    • Enzyme
    • Cytochrome

Connections between topic areas Semantic bridges

For Cytochrome c oxidase subunit 2, one of the stronger structural bridges in this analysis connects Cytochrome c oxidase subunit 2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cytochrome c oxidase subunit 2 — Clinical significance · splits 39 ⟂ 39
Cytochrome c oxidase subunit 2 — Structure · splits 59 ⟂ 19
Cytochrome c oxidase subunit 2 — Overview · splits 69 ⟂ 9
Cytochrome c oxidase subunit 2 — Function · splits 71 ⟂ 7
Cytochrome c oxidase subunit 2 — Interactions · splits 75 ⟂ 3

Map overview Semantic statistics

Cytochrome c oxidase subunit 2

Nodes78
Edges77
Triples102
Avg. degree1.97
Density0.025641
Components1

Source & methodology

TTTA analyzes the structure around Cytochrome c oxidase subunit 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cytochrome c oxidase subunit 2 · EN edition · Analysis: TopicsToTalkAbout

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