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5-HTTLPR

5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Since the polymorphism was identified in the middle of the 1990s, it has been extensively investigated, e.g., in connection with neuropsychiatric disorders. A 2006…

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Chromosome
17
dbSNP
25531
Ensembl
Human SNPView
Gene
SLC6A4
HapMap
25531
SNPedia
25531

Topics to explore

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Overview

Alleles

Neuropsychiatric disorders

Insomnia

Personality traits

Neuroimaging

Electrophysiology

Other organisms

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Map overview Semantic statistics

5-HTTLPR

Nodes71
Edges70
Triples110
Avg. degree1.97
Density0.028169
Components1

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5-HTTLPR

Top relations

related to Personality traits · 20
5-HTTLPR → Angry-Hostility, Another, Anxiety, Character Inventory, Depression, However, HTTLPR, Impulsiveness, In, NEO PI-R, NEO-family, Other, Self-Consciousness, Some, Temperament, The, They, This, Two, Vulnerability
related to Neuroimaging · 17
5-HTTLPR → Another, Associations, Brain, CIT, DASB, HTTLPR, LA, McN, Molecular, MRI, Newer, One, PET, SPECT, Such, The, Using
related to Further reading · 14
5-HTTLPR → Affective Disorders, Archived, Brown GW, Depression, Harris TO, HTTLPR, Journal, LA/LG, Mspl, November, PMID, Retrieved, Serotonin Transporter-Linked Polymorphic Region, SNP
related to Amygdala · 11
5-HTTLPR → DNA, GE Signa, HA, However, HTTLPR, In, Next, Subjects, The, There, Tridimensional Personality Questionnaire
related to Insomnia · 10
5-HTTLPR → HT, HTT, HTTLPR, It, Many, Primary, Research, Serotonin, The, There
related to Brummett · 8
5-HTTLPR → Although, Brummett, Duke University Medical Center, HTTLPR, Index, It, The, The Pittsburgh Sleep Quality
related to Deuschle · 7
5-HTTLPR → Germany, However, HTTLPR, HTTPLR, PCR, The, This
related to Electrophysiology · 7
5-HTTLPR → COMT, Event Related Potentials P3a, HTTLPR, P3a, P3b, The, This
related to External links · 3
5-HTTLPR → HTTLPR, Pointed Review, Slate Star Codex
related to Other organisms · 3
5-HTTLPR → HTTLPR, In, Rattus

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Important terminology

study found insomnia serotonin studies polymorphism long transporter amygdala disorders allele association sleep gene homozygotes short subjects however higher may

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
5-HTTLPRChromosome171.00infobox
5-HTTLPRdbSNP255311.00infobox
5-HTTLPREnsemblHuman SNPView1.00infobox
5-HTTLPRGeneSLC6A41.00infobox
5-HTTLPRHapMap255311.00infobox
5-HTTLPRSNPedia255311.00infobox
anxietyinstance ofThe researchers found a similar effect for the Val66Met polymorphism in the BDNF gene.AmygdalaThe 5-HTTLPR has been thought to predispose individuals to affective disorders0.80text
depressioninstance ofThe researchers found a similar effect for the Val66Met polymorphism in the BDNF gene.AmygdalaThe 5-HTTLPR has been thought to predispose individuals to affective disorders0.80text
anxietyinstance ofAmygdalaThe 5-HTTLPR has been thought to predispose individuals to affective disorders0.80text
depressioninstance ofAmygdalaThe 5-HTTLPR has been thought to predispose individuals to affective disorders0.80text
5-HTTLPRrelated to AmygdalaThe0.60section
5-HTTLPRrelated to AmygdalaHTTLPR0.60section

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