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Prostaglandin E2: History, Applications & Art

Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. In babies it is used in those with congenital heart defects…

Language: English [EN]
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Prostaglandin E2 topic overview

The analysis highlights History, Applications and Art as prominent areas in the source structure around Prostaglandin E2.

Related topics
74
Source areas
7
Connected nodes
81
Extracted relationships
140
Concept neighborhoods
23
Bridge connections
81

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 29 topics
Physiological effects · 29 topics
Medical uses · 7 topics
Mechanism of action · 4 topics
History · 3 topics
Contraindications · 1 topics
Pharmacokinetics · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G02AD02 (WHO)
CAS Number
363-24-6 Y
ChEBI
CHEBI:15551 N
ChEMBL
ChEMBL548 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Physiological effects

Medical uses

Mechanism of action

Contraindications

Pharmacokinetics

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Prostaglandin E2 connects Entity context

The extracted context around Prostaglandin E2 shows recurring relationship patterns in the source. For example, Prostaglandin E2 → Activation, Additionally, Administration, As, C-section, Ca2, Care, Conversely, COX-2, COX-2-derived, COX-2-derived PGE2, E2, EP, EP1, EP2, EP3, EP4, Fever, GFR, In Another extracted example is Prostaglandin E2 → American, British, Corey, E2, Essential Medicines, Euler, FDA, Goldblatt, Prostaglandins, Sune Bergström, Swedish, The, This, Ulf, United States, World Health Organization's List. Use these groups to spot repeated connection types before inspecting the individual relationships.

Prostaglandin E2

Top relations

has effect · 29
Prostaglandin E2 → Activation, Additionally, Administration, As, C-section, Ca2, Care, Conversely, COX-2, COX-2-derived, COX-2-derived PGE2, E2, EP, EP1, EP2, EP3, EP4, Fever, GFR, In
related to history · 16
Prostaglandin E2 → American, British, Corey, E2, Essential Medicines, Euler, FDA, Goldblatt, Prostaglandins, Sune Bergström, Swedish, The, This, Ulf, United States, World Health Organization's List
related to Mechanism of action · 15
Prostaglandin E2 → ADH-mediated, As, EP1, EP2, EP3, EP4, GPCRs, Henle, In, Loop, Na, NSAIDs, PGE2, TAL, Thick Ascending Limb
related to Toxicity · 12
Prostaglandin E2 → C-section, Cervidil, E2, If, Institute, PGE2, Prostin E2, Safe Medication Practices, The, There, This, When
related to Immunity · 10
Prostaglandin E2 → As, E2, EP2, In, PGE2, T-cell, T-lymphocyte, T-lymphocytes, TH1, When
related to Cervical ripening · 8
Prostaglandin E2 → Cervidil, In, PGE2, Pharmacological, Prepidil, Results, The, There
related to Administration · 7
Prostaglandin E2 → Cervidil, For, In, Once, PGE2, The, UK
related to Contraindications · 5
Prostaglandin E2 → Caution, Contraindications, Dinoprostone, PGE2, The
related to Pharmacokinetics · 4
Prostaglandin E2 → E2, NAD, PGE2, The
Legal status · 3
Prostaglandin E2 → EU: Rx-only, UK: POM (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pge2 prostaglandin e2 also used dinoprostone prostaglandins blood effects receptors use within babies vaginal smooth administration labor uterine inflammation muscle

Prostaglandin E2 relationships Subject–Predicate–Object triples

TTTA extracted 140 structured relationships around Prostaglandin E2. Examples in this analysis include Prostaglandin E2 → 3D model (JSmol) → Interactive image and Prostaglandin E2 → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Prostaglandin E23D model (JSmol)Interactive image1.00infobox
Prostaglandin E2AHFS/Drugs.comMonograph1.00infobox
Prostaglandin E2ATC codeG02AD02 (WHO)1.00infobox
Prostaglandin E2CAS Number363-24-6 Y1.00infobox
Prostaglandin E2ChEBICHEBI:15551 N1.00infobox
Prostaglandin E2ChEMBLChEMBL548 N1.00infobox
Prostaglandin E2ChemSpider4444059 N1.00infobox
Prostaglandin E2CompTox Dashboard (EPA)DTXSID40229471.00infobox
Prostaglandin E2DrugBankDB00917 N1.00infobox
Prostaglandin E2ECHA InfoCard100.006.0521.00infobox
Prostaglandin E2FormulaC20H32O51.00infobox
Prostaglandin E2IUPHAR/BPS18831.00infobox
Prostaglandin E2KEGGD000791.00infobox
Prostaglandin E2Legal statusUK: POM (Prescription only)1.00infobox
Prostaglandin E2Legal statusUS: ℞-only1.00infobox
Prostaglandin E2Legal statusEU: Rx-only1.00infobox
Prostaglandin E2License dataEU EMA: by INN1.00infobox
Prostaglandin E2License dataUS DailyMed: Dinoprostone1.00infobox
Prostaglandin E2MedlinePlusa6825121.00infobox
Prostaglandin E2Molar mass352.471 g·mol−11.00infobox
Prostaglandin E2Other namesPGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid1.00infobox
Prostaglandin E2Pregnancy categoryAU: C1.00infobox
Prostaglandin E2PubChem CID52803601.00infobox
Prostaglandin E2Routes of administrationIntravaginal, IV1.00infobox
Prostaglandin E2Trade namesProstin E2, Cervidil, Propess, others1.00infobox
Prostaglandin E2UNIIK7Q1JQR04M1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Prostaglandin E2 bring nearby vocabulary together. In this analysis, examples include Prostaglandin, Pge2 and Side. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Prostaglandin E2
    • Prostaglandin
    • Pge2
    • Side
    • Effects
    • Use
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Smooth
    • Receptors
  • prostaglandin e2
    • Prostaglandin
    • Pge2
    • Use
    • Side
    • Effects
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Medication
    • Smooth
  • prostaglandin
    • Side
    • Effects
    • Use
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Smooth
    • Receptors
    • Administration
    • Common
  • prostaglandin g2
    • Side
    • Effects
    • Use
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Smooth
    • Receptors
    • Administration
    • Common
  • prostaglandin h2
    • Side
    • Effects
    • Use
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Smooth
    • Receptors
    • Administration
    • Common
  • prostaglandin e2 receptor
    • Prostaglandin
    • Pge2
    • Use
    • Side
    • Effects
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Medication
    • Smooth
  • prostaglandin e1
    • Side
    • Effects
    • Use
    • Cervix
    • Ep2
    • Labor
    • Muscle
    • Uterine
    • Smooth
    • Receptors
    • Administration
    • Common
  • physiological effects
    • Side
    • Muscle
    • Smooth
    • Administration
    • Fever
    • Uterine
    • Prostaglandin
    • Pge2
    • Receptors
    • Pregnancy
    • Cervix
    • Results

Connections between topic areas Semantic bridges

For Prostaglandin E2, one of the stronger structural bridges in this analysis connects Prostaglandin E2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Prostaglandin E2Overview · splits 52 ⟂ 30
Prostaglandin E2Physiological effects · splits 52 ⟂ 30
Prostaglandin E2Medical uses · splits 74 ⟂ 8
Prostaglandin E2Mechanism of action · splits 77 ⟂ 5
Prostaglandin E2History · splits 78 ⟂ 4

Map overview Semantic statistics

Prostaglandin E2

Nodes82
Edges81
Triples140
Avg. degree1.98
Density0.02439
Components1

Source & methodology

TTTA analyzes the structure around Prostaglandin E2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Prostaglandin E2 · EN edition · Analysis: TopicsToTalkAbout

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