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Isotretinoin

Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. Isotretinoin is used off-label to treat basal cell carcinoma and squamous cell…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D10AD04 (WHO)
Bioavailability
Variable
CAS Number
4759-48-2 Y
ChEBI
CHEBI:6067 Y

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Overview

Medical uses

Adverse effects

Pharmacology

History

Brands

Advanced semantic analysis

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Map overview Semantic statistics

Isotretinoin

Nodes152
Edges151
Triples279
Avg. degree1.99
Density0.013158
Components1

How this topic connects Entity context

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Isotretinoin

Top relations

related to Brands · 132
Isotretinoin → A-Cnotren, Absorica, Accuran, Accutane, Accutin, Acne Free, Acnecutan, Acnegen, Acnemin, Acneone, Acneral, Acnestar, Acnetane, Acnetin, Acnetrait, Acnetrex, Acnogen, Acnotin, Acnotren, Acretin
related to history · 21
Isotretinoin → Accutane, After Peck, By, CDC, Centers, Despite, Disease Control, Drug Administration, FDA, Food, Gary Peck, Hoffmann-La Roche, However, In, National Cancer Institute, New Drug Application, Prevention, Roche, Roche Laboratories, Werner Bollag
has effect · 13
Isotretinoin → Accutane, B16F-10, Dalton's, However, In, March, Premature, Psychological, The, There, This, UK's MHRA, Very
related to Pharmacokinetics and pharmacodynamics · 10
Isotretinoin → Accutane, After, Due, John's Wort, Oral, OrthoNovum, SD, St, The, Three
related to Prescribing restrictions · 9
Isotretinoin → Additionally, Because, Drug Administration, Food, In, March, Prescribers, United States, Women
related to Eyes · 8
Isotretinoin → Dry, IIH, In, Meibomian Gland Dysfunction, MGD, More, Other, Some
related to Mechanism of action · 8
Isotretinoin → Cell, Cutibacterium, Isotretinoin's, NGAL, One, RAR, RXR, The
related to Musculoskeletal · 8
Isotretinoin → Most, Myalgia, Other, Retinoids, Risk, The, While, X-ray
related to Sexual · 8
Isotretinoin → August, Drug Safety Update, EU, In October, The, There, This, UK MHRA
Legal status · 7
Isotretinoin → AU: S4 (Prescription only), BR: Class C2 (Retinoids), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

effects also drug side depression may acne use treatment people accutane include cause acid women fda skin psychosis roche defects

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Isotretinoin3D model (JSmol)Interactive image1.00infobox
IsotretinoinAHFS/Drugs.comMonograph1.00infobox
IsotretinoinATC codeD10AD04 (WHO)1.00infobox
IsotretinoinBioavailabilityVariable1.00infobox
IsotretinoinCAS Number4759-48-2 Y1.00infobox
IsotretinoinChEBICHEBI:6067 Y1.00infobox
IsotretinoinChEMBLChEMBL547 Y1.00infobox
IsotretinoinChemSpider4445539 Y1.00infobox
IsotretinoinCompTox Dashboard (EPA)DTXSID40231771.00infobox
IsotretinoinDrugBankDB00982 Y1.00infobox
IsotretinoinECHA InfoCard100.022.9961.00infobox
IsotretinoinElimination half-life10–20 hours1.00infobox
IsotretinoinExcretionKidney and feces1.00infobox
IsotretinoinFormulaC20H28O21.00infobox
IsotretinoinIUPHAR/BPS76001.00infobox
IsotretinoinKEGGD00348 Y1.00infobox
IsotretinoinLegal statusAU: S4 (Prescription only)1.00infobox
IsotretinoinLegal statusBR: Class C2 (Retinoids)1.00infobox
IsotretinoinLegal statusCA: ℞-only1.00infobox
IsotretinoinLegal statusUK: POM (Prescription only)1.00infobox
IsotretinoinLegal statusUS: ℞-only1.00infobox
IsotretinoinLegal statusEU: Rx-only1.00infobox
IsotretinoinLegal statusIn general: ℞ (Prescription only)1.00infobox
IsotretinoinLicense dataUS DailyMed: Isotretinoin1.00infobox
IsotretinoinMedlinePlusa6810431.00infobox
IsotretinoinMetabolismLiver1.00infobox
IsotretinoinMolar mass300.442 g·mol−11.00infobox
IsotretinoinPregnancy categoryAU: X (High risk)1.00infobox
IsotretinoinPronunciationSee note at tretinoin1.00infobox
IsotretinoinProtein binding99.9%1.00infobox

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