Isotretinoin

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Isotretinoin topic overview

The analysis highlights History, Applications and Standards as prominent areas in the source structure around Isotretinoin.

Related topics: 145
Source areas: 6
Connected nodes: 151
Extracted relationships: 279
Concept neighborhoods: 20
Bridge connections: 151

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 47 topics

Overview · 43 topics

Pharmacology · 29 topics

Medical uses · 12 topics

History · 11 topics

Brands · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: D10AD04 (WHO)
Bioavailability: Variable
CAS Number: 4759-48-2 Y
ChEBI: CHEBI:6067 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Harlequin-type ichthyosis
Lamellar ichthyosis
Acne
Basal cell carcinoma Basal-cell carcinoma
Squamous cell carcinoma Squamous-cell carcinoma
Retinoid
Vitamin A
Isomer
Tretinoin
Cheilitis
Xeroderma
Dry eyes Dry eye syndrome
Increased susceptibility to sunburn Phototoxicity
Myalgias Myalgia
Liver failure
Blood levels Reference ranges for blood tests
Birth defects Teratogen
Retinoic acid
Psychosis
Hyperostosis
Epiphyseal closure
FDA Food and Drug Administration
Black box warning Boxed warning
European Medicines Agency
Challenge/dechallenge/rechallenge Challenge–dechallenge–rechallenge
Several biological processes Isotretinoin
Dopamine D2 receptor Dopamine receptor D2
Glutamate receptors Glutamate receptor
Cascade Gene regulatory network
Gene loci Locus (genetics)
Orbitofrontal cortex
Frontal cortex Frontal lobe
Dopaminergic receptors Dopamine receptor
Neurotransmission
Serotonergic Serotonin
5-HT1A receptors 5-HT1A receptor
Serotonin transporter protein Serotonin transporter
Reuptake
Hippocampal Hippocampus
Neurogenesis
Hypothalamus
Hypothalamus-pituitary-adrenal axis Hypothalamic–pituitary–adrenal axis
Striatum

Medical uses

Brands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Isotretinoin connects Entity context

The extracted context around Isotretinoin shows recurring relationship patterns in the source. For example, Isotretinoin → A-Cnotren, Absorica, Accuran, Accutane, Accutin, Acne Free, Acnecutan, Acnegen, Acnemin, Acneone, Acneral, Acnestar, Acnetane, Acnetin, Acnetrait, Acnetrex, Acnogen, Acnotin, Acnotren, Acretin Another extracted example is Isotretinoin → Accutane, After Peck, By, CDC, Centers, Despite, Disease Control, Drug Administration, FDA, Food, Gary Peck, Hoffmann-La Roche, However, In, National Cancer Institute, New Drug Application, Prevention, Roche, Roche Laboratories, Werner Bollag. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Brands · 132

Isotretinoin → A-Cnotren, Absorica, Accuran, Accutane, Accutin, Acne Free, Acnecutan, Acnegen, Acnemin, Acneone, Acneral, Acnestar, Acnetane, Acnetin, Acnetrait, Acnetrex, Acnogen, Acnotin, Acnotren, Acretin

related to history · 21

Isotretinoin → Accutane, After Peck, By, CDC, Centers, Despite, Disease Control, Drug Administration, FDA, Food, Gary Peck, Hoffmann-La Roche, However, In, National Cancer Institute, New Drug Application, Prevention, Roche, Roche Laboratories, Werner Bollag

has effect · 13

Isotretinoin → Accutane, B16F-10, Dalton's, However, In, March, Premature, Psychological, The, There, This, UK's MHRA, Very

related to Pharmacokinetics and pharmacodynamics · 10

Isotretinoin → Accutane, After, Due, John's Wort, Oral, OrthoNovum, SD, St, The, Three

related to Prescribing restrictions · 9

Isotretinoin → Additionally, Because, Drug Administration, Food, In, March, Prescribers, United States, Women

related to Eyes · 8

Isotretinoin → Dry, IIH, In, Meibomian Gland Dysfunction, MGD, More, Other, Some

related to Mechanism of action · 8

Isotretinoin → Cell, Cutibacterium, Isotretinoin's, NGAL, One, RAR, RXR, The

related to Musculoskeletal · 8

Isotretinoin → Most, Myalgia, Other, Retinoids, Risk, The, While, X-ray

related to Sexual · 8

Isotretinoin → August, Drug Safety Update, EU, In October, The, There, This, UK MHRA

Legal status · 7

Isotretinoin → AU: S4 (Prescription only), BR: Class C2 (Retinoids), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects also drug side depression may acne use treatment people accutane include cause acid women fda skin psychosis roche defects

Isotretinoin relationships Subject–Predicate–Object triples

TTTA extracted 279 structured relationships around Isotretinoin. Examples in this analysis include Isotretinoin → 3D model (JSmol) → Interactive image and Isotretinoin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Isotretinoin	3D model (JSmol)	Interactive image	1.00	infobox
Isotretinoin	AHFS/Drugs.com	Monograph	1.00	infobox
Isotretinoin	ATC code	D10AD04 (WHO)	1.00	infobox
Isotretinoin	Bioavailability	Variable	1.00	infobox
Isotretinoin	CAS Number	4759-48-2 Y	1.00	infobox
Isotretinoin	ChEBI	CHEBI:6067 Y	1.00	infobox
Isotretinoin	ChEMBL	ChEMBL547 Y	1.00	infobox
Isotretinoin	ChemSpider	4445539 Y	1.00	infobox
Isotretinoin	CompTox Dashboard (EPA)	DTXSID4023177	1.00	infobox
Isotretinoin	DrugBank	DB00982 Y	1.00	infobox
Isotretinoin	ECHA InfoCard	100.022.996	1.00	infobox
Isotretinoin	Elimination half-life	10–20 hours	1.00	infobox
Isotretinoin	Excretion	Kidney and feces	1.00	infobox
Isotretinoin	Formula	C20H28O2	1.00	infobox
Isotretinoin	IUPHAR/BPS	7600	1.00	infobox
Isotretinoin	KEGG	D00348 Y	1.00	infobox
Isotretinoin	Legal status	AU: S4 (Prescription only)	1.00	infobox
Isotretinoin	Legal status	BR: Class C2 (Retinoids)	1.00	infobox
Isotretinoin	Legal status	CA: ℞-only	1.00	infobox
Isotretinoin	Legal status	UK: POM (Prescription only)	1.00	infobox
Isotretinoin	Legal status	US: ℞-only	1.00	infobox
Isotretinoin	Legal status	EU: Rx-only	1.00	infobox
Isotretinoin	Legal status	In general: ℞ (Prescription only)	1.00	infobox
Isotretinoin	License data	US DailyMed: Isotretinoin	1.00	infobox
Isotretinoin	MedlinePlus	a681043	1.00	infobox
Isotretinoin	Metabolism	Liver	1.00	infobox
Isotretinoin	Molar mass	300.442 g·mol−1	1.00	infobox
Isotretinoin	Pregnancy category	AU: X (High risk)	1.00	infobox
Isotretinoin	Pronunciation	See note at tretinoin	1.00	infobox
Isotretinoin	Protein binding	99.9%	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Isotretinoin bring nearby vocabulary together. In this analysis, examples include Use, Acne and May. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Isotretinoin
- Use
- Acne
- May
- Women
- Depression
- Drug
- Acid
- Retinoids
- Known
- Receptors
- Risk
- Used
isotretinoin
- Use
- Acne
- May
- Women
- Depression
- Drug
- Acid
- Retinoids
- Known
- Receptors
- Risk
- Used
acne
- Treatment
- Skin
- Isotretinoin
- Roche
- Drug
- Also
- Known
- Used
- Fda
- Use
- May
- Retinoids
retinoic acid
- Retinoic
- Receptors
- Skin
- Known
- Roche
- Used
- Accutane
- Acne
- Isotretinoin
- Due
- Retinoids
- Psychosis
retinoic acid receptors
- Retinoic
- Receptors
- Skin
- Retinoids
- Known
- Roche
- Used
- Accutane
- Acne
- Isotretinoin
- Due
- Psychosis
erythromycin/isotretinoin
- Use
- Acne
- May
- Women
- Depression
- Drug
- Acid
- Retinoids
- Known
- Receptors
- Risk
- Used
adverse effects
- Side
- Include
- Depression
- May
- Rare
- Psychosis
- Associated
- Skin
- Risk
- Roche
- Isotretinoin
- Retinoids
new drug application
- Taking
- Associated
- Defects
- Fda
- Isotretinoin
- Reports
- Birth
- Women
- People
- Use
- Suicide
- Cases

Connections between topic areas Semantic bridges

For Isotretinoin, one of the stronger structural bridges in this analysis connects Isotretinoin with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Isotretinoin — Adverse effects · splits 104 ⟂ 48

Isotretinoin — Overview · splits 108 ⟂ 44

Isotretinoin — Pharmacology · splits 122 ⟂ 30

Isotretinoin — Medical uses · splits 139 ⟂ 13

Isotretinoin — History · splits 140 ⟂ 12

Isotretinoin — Brands · splits 148 ⟂ 4

Map overview Semantic statistics

Isotretinoin

Nodes152

Edges151

Triples279

Avg. degree1.99

Density0.013158

Components1

Source & methodology

TTTA analyzes the structure around Isotretinoin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Isotretinoin · EN edition · Analysis: TopicsToTalkAbout