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Isotretinoin: History, Applications & Standards
Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. Isotretinoin is used off-label to treat basal cell carcinoma and squamous cell…
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Isotretinoin topic overview
The analysis highlights History, Applications and Standards as prominent areas in the source structure around Isotretinoin.
Related topics
143
Source areas
6
Connected nodes
149
Extracted relationships
243
Related term clusters
20
Bridge connections
149
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Adverse effects · 45 topics
Overview · 43 topics
Pharmacology · 29 topics
Medical uses · 12 topics
History · 11 topics
Brands · 3 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D10AD04 (WHO)
Bioavailability
Variable
CAS Number
4759-48-2 Y
ChEBI
CHEBI:6067 Y
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Advanced semantic analysis
How Isotretinoin connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Isotretinoin shows recurring relationship patterns in the source. For example, Isotretinoin → A-Cnotren, Absorica, Accuran, Accutane, Accutin, Acne Free, Acnecutan, Acnegen, Acnemin, Acneone, Acneral, Acnestar, Acnetane, Acnetin, Acnetrait, Acnetrex, Acnogen, Acnotin, Acnotren, Acretin Another extracted example is Isotretinoin → Accutane, After Peck, CDC, Centers, Despite, Disease Control, Drug Administration, FDA, Food, Gary Peck, Hoffmann-La Roche, National Cancer Institute, New Drug Application, Prevention, Roche, Roche Laboratories, Werner Bollag. Use these groups to spot repeated connection types before inspecting the individual relationships.
Isotretinoin → Accutane, After Peck, CDC, Centers, Despite, Disease Control, Drug Administration, FDA, Food, Gary Peck, Hoffmann-La Roche, National Cancer Institute, New Drug Application, Prevention, Roche, Roche Laboratories, Werner Bollag
related to Pharmacokinetics and pharmacodynamics· 8
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 243 structured relationships around Isotretinoin. Examples in this analysis include Isotretinoin → 3D model (JSmol) → Interactive image and Isotretinoin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Isotretinoin
3D model (JSmol)
Interactive image
1.00
infobox
Isotretinoin
AHFS/Drugs.com
Monograph
1.00
infobox
Isotretinoin
ATC code
D10AD04 (WHO)
1.00
infobox
Isotretinoin
Bioavailability
Variable
1.00
infobox
Isotretinoin
CAS Number
4759-48-2 Y
1.00
infobox
Isotretinoin
ChEBI
CHEBI:6067 Y
1.00
infobox
Isotretinoin
ChEMBL
ChEMBL547 Y
1.00
infobox
Isotretinoin
ChemSpider
4445539 Y
1.00
infobox
Isotretinoin
CompTox Dashboard (EPA)
DTXSID4023177
1.00
infobox
Isotretinoin
DrugBank
DB00982 Y
1.00
infobox
Isotretinoin
ECHA InfoCard
100.022.996
1.00
infobox
Isotretinoin
Elimination half-life
10–20 hours
1.00
infobox
Isotretinoin
Excretion
Kidney and feces
1.00
infobox
Isotretinoin
Formula
C20H28O2
1.00
infobox
Isotretinoin
IUPHAR/BPS
7600
1.00
infobox
Isotretinoin
KEGG
D00348 Y
1.00
infobox
Isotretinoin
Legal status
AU: S4 (Prescription only)
1.00
infobox
Isotretinoin
Legal status
BR: Class C2 (Retinoids)
1.00
infobox
Isotretinoin
Legal status
CA: ℞-only
1.00
infobox
Isotretinoin
Legal status
UK: POM (Prescription only)
1.00
infobox
Isotretinoin
Legal status
US: ℞-only
1.00
infobox
Isotretinoin
Legal status
EU: Rx-only
1.00
infobox
Isotretinoin
Legal status
In general: ℞ (Prescription only)
1.00
infobox
Isotretinoin
License data
US DailyMed: Isotretinoin
1.00
infobox
Isotretinoin
MedlinePlus
a681043
1.00
infobox
Isotretinoin
Metabolism
Liver
1.00
infobox
Isotretinoin
Molar mass
300.442 g·mol−1
1.00
infobox
Isotretinoin
Pregnancy category
AU: X (High risk)
1.00
infobox
Isotretinoin
Pronunciation
See note at tretinoin
1.00
infobox
Isotretinoin
Protein binding
99.9%
1.00
infobox
No triples extracted yet.
Related concept clusters Related term clusters
Related term clusters group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Isotretinoin bring nearby vocabulary together. In this analysis, examples include Use, Acne and May. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Isotretinoin
Use
Acne
May
Women
Depression
Drug
Acid
Retinoids
Known
Receptors
Risk
Used
isotretinoin
Use
Acne
May
Women
Depression
Drug
Acid
Retinoids
Known
Receptors
Risk
Used
acne
Treatment
Skin
Isotretinoin
Roche
Drug
Also
Known
Used
Fda
Use
May
Retinoids
retinoic acid
Retinoic
Receptors
Skin
Known
Roche
Used
Accutane
Acne
Isotretinoin
Due
Retinoids
Psychosis
retinoic acid receptors
Retinoic
Receptors
Skin
Retinoids
Known
Roche
Used
Accutane
Acne
Isotretinoin
Due
Psychosis
erythromycin/isotretinoin
Use
Acne
May
Women
Depression
Drug
Acid
Retinoids
Known
Receptors
Risk
Used
adverse effects
Side
Include
Depression
May
Rare
Psychosis
Associated
Skin
Risk
Roche
Isotretinoin
Retinoids
new drug application
Taking
Associated
Defects
Fda
Isotretinoin
Reports
Birth
Women
People
Use
Suicide
Cases
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Isotretinoin, one of the stronger structural bridges in this analysis connects Isotretinoin with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Isotretinoin
Nodes150
Edges149
Triples243
Avg. degree1.99
Density0.013333
Components1
Source & methodology
TTTA analyzes the structure around Isotretinoin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
