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TSC1: Art & Regions

Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.

Language: English [EN]
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TSC1 topic overview

The analysis highlights Art and Regions as prominent areas in the source structure around TSC1.

Related topics
23
Source areas
4
Connected nodes
27
Extracted relationships
146
Concept neighborhoods
13
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics
Clinical significance · 6 topics
Interactions · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EJC, 4Z6Y
Band
9q34.13 · 2|2 A3
Bgee
pars compacta · glutes · external globus pallidus · Region I of hippocampus proper · pars reticulata
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TSC1 connects Entity context

The extracted context around TSC1 shows recurring relationship patterns in the source. For example, TSC1 → actin filament, activation of GTPase activity, adaptive immune response, adult locomotory behavior, ATPase inhibitor activity, cardiac muscle cell differentiation, cell cortex, cell projection, cell projection organization, cell-matrix adhesion, cellular response to oxygen-glucose deprivation, cerebral cortex development, chaperone binding, chaperone complex, cytoplasm, cytoskeleton, cytosol, glucose import, growth cone, GTPase activating protein binding Another extracted example is TSC1 → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, external globus pallidus, glutes, inferior olivary nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, mammillary body, middle temporal gyrus, paraventricular nucleus of hypothalamus, pars compacta, pars reticulata, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior vestibular nucleus, supraoptic nucleus, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

TSC1

Top relations

Gene ontology · 67
TSC1 → actin filament, activation of GTPase activity, adaptive immune response, adult locomotory behavior, ATPase inhibitor activity, cardiac muscle cell differentiation, cell cortex, cell projection, cell projection organization, cell-matrix adhesion, cellular response to oxygen-glucose deprivation, cerebral cortex development, chaperone binding, chaperone complex, cytoplasm, cytoskeleton, cytosol, glucose import, growth cone, GTPase activating protein binding
Bgee · 20
TSC1 → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, external globus pallidus, glutes, inferior olivary nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, mammillary body, middle temporal gyrus, paraventricular nucleus of hypothalamus, pars compacta, pars reticulata, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior vestibular nucleus, supraoptic nucleus, ventromedial nucleus
RNA expression pattern · 20
TSC1 → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, external globus pallidus, glutes, inferior olivary nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, mammillary body, middle temporal gyrus, paraventricular nucleus of hypothalamus, pars compacta, pars reticulata, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior vestibular nucleus, supraoptic nucleus, ventromedial nucleus
related to Function · 10
TSC1 → ATPase, GAP, GTPase Rheb, GTPase-activating, Hsp90, TBC1D7, The TSC, This, TSC, TSC2
related to Clinical significance · 3
TSC1 → CA3, Defects, TSC
related to Interactions · 3
TSC1 → AKT1, HSP70HSP90NEFL, PLK1
Band · 2
TSC1 → 2|2 A3, 9q34.13
Chr. · 2
TSC1 → Chromosome 2 (mouse), Chromosome 9 (human)
End · 2
TSC1 → 132,946,874 bp, 28,581,179 bp
Aliases · 1
TSC1 → TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp complex gene chr human band chromosome protein also tuberous sclerosis hsp90 external tsc location tsc2 mouse function pdb uniprot

TSC1 relationships Subject–Predicate–Object triples

TTTA extracted 146 structured relationships around TSC1. Examples in this analysis include TSC1 → Aliases → TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1 and TSC1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EJC, 4Z6Y. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TSC1AliasesTSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 11.00infobox
TSC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EJC, 4Z6Y1.00infobox
TSC1Band9q34.131.00infobox
TSC1Band2|2 A31.00infobox
TSC1Bgeepars compacta1.00infobox
TSC1Bgeeglutes1.00infobox
TSC1Bgeeexternal globus pallidus1.00infobox
TSC1BgeeRegion I of hippocampus proper1.00infobox
TSC1Bgeepars reticulata1.00infobox
TSC1Bgeelateral nuclear group of thalamus1.00infobox
TSC1Bgeedorsal motor nucleus of vagus nerve1.00infobox
TSC1Bgeeinferior olivary nucleus1.00infobox
TSC1Bgeesuperior vestibular nucleus1.00infobox
TSC1Bgeemiddle temporal gyrus1.00infobox
TSC1Bgeeventromedial nucleus1.00infobox
TSC1Bgeelateral hypothalamus1.00infobox
TSC1Bgeelateral septal nucleus1.00infobox
TSC1Bgeeanterior amygdaloid area1.00infobox
TSC1Bgeesupraoptic nucleus1.00infobox
TSC1BgeeRostral migratory stream1.00infobox
TSC1Bgeeparaventricular nucleus of hypothalamus1.00infobox
TSC1Bgeesubstantia nigra1.00infobox
TSC1Bgeemammillary body1.00infobox
TSC1Bgeearcuate nucleus1.00infobox
TSC1BioGPSMore reference expression data1.00infobox
TSC1Chr.Chromosome 9 (human)1.00infobox
TSC1Chr.Chromosome 2 (mouse)1.00infobox
TSC1DatabasesNCBI: entry; OMA: entry1.00infobox
TSC1End132,946,874 bp1.00infobox
TSC1End28,581,179 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TSC1 bring nearby vocabulary together. In this analysis, examples include Also, Tuberous and Complex. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TSC1
    • Also
    • Tuberous
    • Complex
    • Gene
    • Hsp90
    • Tsc2
    • Protein
    • Tsc
    • Available
    • Entry
    • External
    • Function
  • tsc1
    • Also
    • Tuberous
    • Complex
    • Gene
    • Hsp90
    • Tsc2
    • Protein
    • Tsc
    • Available
    • Entry
    • External
    • Function
  • protein
    • Entry
    • Hsp70
    • Ncbi
    • Q92574
    • Uniprot
    • Hsp90
    • Complex
    • Tsc1
    • Sclerosis
    • Tuberous
    • Gene
    • Atpase
  • gene
    • Location
    • Chromosome
    • Human
    • Sclerosis
    • Tsc1
    • Tuberous
    • Bp
    • Chr
    • End
    • External
    • Function
    • Hippocampus
  • gtpase-activating protein
    • Entry
    • Hsp70
    • Ncbi
    • Q92574
    • Uniprot
    • Hsp90
    • Complex
    • Tsc1
    • Sclerosis
    • Tuberous
    • Gene
    • Atpase
  • tuberous sclerosis
    • Tuberous
    • Also
    • Tsc1
    • Available
    • Gene
    • Hamartin
    • Pdb
    • Complex
    • Protein
    • Tsc
    • Entry
    • External
  • function
    • Search
    • Location
    • Atpase
    • Chaperone
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Available
    • End
    • Entry
  • hippocampus
    • Region
    • Entry
    • Hsp70
    • Kinase
    • Mouse
    • Ncbi
    • Q92574
    • Search
    • Uniprot
    • Tsc1
    • Hsp90
    • Location

Connections between topic areas Semantic bridges

For TSC1, one of the stronger structural bridges in this analysis connects TSC1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TSC1Function · splits 17 ⟂ 11
TSC1Clinical significance · splits 21 ⟂ 7
TSC1Interactions · splits 22 ⟂ 6
TSC1Overview · splits 25 ⟂ 3

Map overview Semantic statistics

TSC1

Nodes28
Edges27
Triples146
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around TSC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TSC1 · EN edition · Analysis: TopicsToTalkAbout

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