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TSC1

Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.

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Function

10 related topics

Clinical significance

6 related topics

Interactions

5 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EJC, 4Z6Y
Band
9q34.13 · 2|2 A3
Bgee
pars compacta · glutes · external globus pallidus · Region I of hippocampus proper · pars reticulata
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

TSC1

Nodes28
Edges27
Triples146
Avg. degree1.93
Density0.071429
Components1

How this topic connects Entity context

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TSC1

Top relations

Gene ontology · 67
TSC1 → actin filament, activation of GTPase activity, adaptive immune response, adult locomotory behavior, ATPase inhibitor activity, cardiac muscle cell differentiation, cell cortex, cell projection, cell projection organization, cell-matrix adhesion, cellular response to oxygen-glucose deprivation, cerebral cortex development, chaperone binding, chaperone complex, cytoplasm, cytoskeleton, cytosol, glucose import, growth cone, GTPase activating protein binding
Bgee · 20
TSC1 → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, external globus pallidus, glutes, inferior olivary nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, mammillary body, middle temporal gyrus, paraventricular nucleus of hypothalamus, pars compacta, pars reticulata, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior vestibular nucleus, supraoptic nucleus, ventromedial nucleus
RNA expression pattern · 20
TSC1 → anterior amygdaloid area, arcuate nucleus, dorsal motor nucleus of vagus nerve, external globus pallidus, glutes, inferior olivary nucleus, lateral hypothalamus, lateral nuclear group of thalamus, lateral septal nucleus, mammillary body, middle temporal gyrus, paraventricular nucleus of hypothalamus, pars compacta, pars reticulata, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior vestibular nucleus, supraoptic nucleus, ventromedial nucleus
related to Function · 10
TSC1 → ATPase, GAP, GTPase Rheb, GTPase-activating, Hsp90, TBC1D7, The TSC, This, TSC, TSC2
related to Clinical significance · 3
TSC1 → CA3, Defects, TSC
related to Interactions · 3
TSC1 → AKT1, HSP70HSP90NEFL, PLK1
Band · 2
TSC1 → 2|2 A3, 9q34.13
Chr. · 2
TSC1 → Chromosome 2 (mouse), Chromosome 9 (human)
End · 2
TSC1 → 132,946,874 bp, 28,581,179 bp
Aliases · 1
TSC1 → TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1

Important terminology Word statistics

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Important terminology

bp complex gene chr human band chromosome protein also tuberous sclerosis hsp90 external tsc location tsc2 mouse function pdb uniprot

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TSC1AliasesTSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 11.00infobox
TSC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EJC, 4Z6Y1.00infobox
TSC1Band9q34.131.00infobox
TSC1Band2|2 A31.00infobox
TSC1Bgeepars compacta1.00infobox
TSC1Bgeeglutes1.00infobox
TSC1Bgeeexternal globus pallidus1.00infobox
TSC1BgeeRegion I of hippocampus proper1.00infobox
TSC1Bgeepars reticulata1.00infobox
TSC1Bgeelateral nuclear group of thalamus1.00infobox
TSC1Bgeedorsal motor nucleus of vagus nerve1.00infobox
TSC1Bgeeinferior olivary nucleus1.00infobox
TSC1Bgeesuperior vestibular nucleus1.00infobox
TSC1Bgeemiddle temporal gyrus1.00infobox
TSC1Bgeeventromedial nucleus1.00infobox
TSC1Bgeelateral hypothalamus1.00infobox
TSC1Bgeelateral septal nucleus1.00infobox
TSC1Bgeeanterior amygdaloid area1.00infobox
TSC1Bgeesupraoptic nucleus1.00infobox
TSC1BgeeRostral migratory stream1.00infobox
TSC1Bgeeparaventricular nucleus of hypothalamus1.00infobox
TSC1Bgeesubstantia nigra1.00infobox
TSC1Bgeemammillary body1.00infobox
TSC1Bgeearcuate nucleus1.00infobox
TSC1BioGPSMore reference expression data1.00infobox
TSC1Chr.Chromosome 9 (human)1.00infobox
TSC1Chr.Chromosome 2 (mouse)1.00infobox
TSC1DatabasesNCBI: entry; OMA: entry1.00infobox
TSC1End132,946,874 bp1.00infobox
TSC1End28,581,179 bp1.00infobox

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