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Insulin-like growth factor 1: Applications & Art

Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. In the 1950s IGF1 was called "sulfation factor" because it stimulated sulfation of cartilage in vitro, and in the 1970s due to its effects it was…

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Insulin-like growth factor 1 topic overview

The analysis highlights Applications and Art as prominent areas in the source structure around Insulin-like growth factor 1.

Related topics
140
Source areas
8
Connected nodes
148
Extracted relationships
161
Concept neighborhoods
51
Bridge connections
148

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanism of action · 61 topics
Overview · 29 topics
Related disorders · 22 topics
Causes of elevated IGF1 levels · 8 topics
Health effects · 7 topics
Use as a diagnostic test · 7 topics
Synthesis and circulation · 4 topics
Causes of reduced IGF1 levels · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
Band
12q23.2 · 10 C1|10 43.7 cM
Bgee
pericardium · tail of epididymis · tendon of biceps brachii · gastric mucosa · superficial temporal artery
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Synthesis and circulation

Mechanism of action

Related disorders

Use as a diagnostic test

Causes of elevated IGF1 levels

Causes of reduced IGF1 levels

Health effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Insulin-like growth factor 1 connects Entity context

The extracted context around Insulin-like growth factor 1 shows recurring relationship patterns in the source. For example, Insulin-like growth factor 1 → activation of protein kinase B activity, alphav-beta3 integrin-IGF-1-IGF1R complex, bone mineralization involved in bone maturation, cell activation, cell population proliferation, cellular response to amyloid-beta, DNA replication, ERK1 and ERK2 cascade, exocytic vesicle, extracellular region, extracellular space, glycolate metabolic process, growth factor activity, hormone activity, insulin receptor binding, insulin-like growth factor binding protein complex, insulin-like growth factor receptor binding, insulin-like growth factor receptor signaling pathway, insulin-like growth factor ternary complex, integrin binding Another extracted example is Insulin-like growth factor 1 → caput epididymis, corpus epididymis, efferent ductule, endometrium, external carotid artery, gallbladder, gastric mucosa, genital tubercle, internal carotid artery, iris, left lobe of liver, pericardium, seminal vesicula, stria vascularis, stroma of bone marrow, superficial temporal artery, tail of epididymis, tendon of biceps brachii, urethra, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

Insulin-like growth factor 1

Top relations

Gene ontology · 84
Insulin-like growth factor 1 → activation of protein kinase B activity, alphav-beta3 integrin-IGF-1-IGF1R complex, bone mineralization involved in bone maturation, cell activation, cell population proliferation, cellular response to amyloid-beta, DNA replication, ERK1 and ERK2 cascade, exocytic vesicle, extracellular region, extracellular space, glycolate metabolic process, growth factor activity, hormone activity, insulin receptor binding, insulin-like growth factor binding protein complex, insulin-like growth factor receptor binding, insulin-like growth factor receptor signaling pathway, insulin-like growth factor ternary complex, integrin binding
Bgee · 20
Insulin-like growth factor 1 → caput epididymis, corpus epididymis, efferent ductule, endometrium, external carotid artery, gallbladder, gastric mucosa, genital tubercle, internal carotid artery, iris, left lobe of liver, pericardium, seminal vesicula, stria vascularis, stroma of bone marrow, superficial temporal artery, tail of epididymis, tendon of biceps brachii, urethra, white adipose tissue
RNA expression pattern · 20
Insulin-like growth factor 1 → caput epididymis, corpus epididymis, efferent ductule, endometrium, external carotid artery, gallbladder, gastric mucosa, genital tubercle, internal carotid artery, iris, left lobe of liver, pericardium, seminal vesicula, stria vascularis, stroma of bone marrow, superficial temporal artery, tail of epididymis, tendon of biceps brachii, urethra, white adipose tissue
related to Laron syndrome · 10
Insulin-like growth factor 1 → Affected, GH, GHR, GHRD, IGF-1, It, Laron, LS, The, Zvi Laron
Band · 2
Insulin-like growth factor 1 → 10 C1|10 43.7 cM, 12q23.2
Chr. · 2
Insulin-like growth factor 1 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
Insulin-like growth factor 1 → 102,481,744 bp, 87,772,904 bp
Aliases · 1
Insulin-like growth factor 1 → IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
Available structures · 1
Insulin-like growth factor 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS
BioGPS · 1
Insulin-like growth factor 1 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

igf1 growth hormone levels cell insulin factor liver insulin-like gh effects protein metabolic associated bp also disease receptor production binding

Insulin-like growth factor 1 relationships Subject–Predicate–Object triples

TTTA extracted 161 structured relationships around Insulin-like growth factor 1. Examples in this analysis include Insulin-like growth factor 1 → Aliases → IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF and Insulin-like growth factor 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Insulin-like growth factor 1AliasesIGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF1.00infobox
Insulin-like growth factor 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS1.00infobox
Insulin-like growth factor 1Band12q23.21.00infobox
Insulin-like growth factor 1Band10 C1|10 43.7 cM1.00infobox
Insulin-like growth factor 1Bgeepericardium1.00infobox
Insulin-like growth factor 1Bgeetail of epididymis1.00infobox
Insulin-like growth factor 1Bgeetendon of biceps brachii1.00infobox
Insulin-like growth factor 1Bgeegastric mucosa1.00infobox
Insulin-like growth factor 1Bgeesuperficial temporal artery1.00infobox
Insulin-like growth factor 1Bgeeseminal vesicula1.00infobox
Insulin-like growth factor 1Bgeeurethra1.00infobox
Insulin-like growth factor 1Bgeecaput epididymis1.00infobox
Insulin-like growth factor 1Bgeecorpus epididymis1.00infobox
Insulin-like growth factor 1Bgeeendometrium1.00infobox
Insulin-like growth factor 1Bgeestria vascularis1.00infobox
Insulin-like growth factor 1Bgeeinternal carotid artery1.00infobox
Insulin-like growth factor 1Bgeeefferent ductule1.00infobox
Insulin-like growth factor 1Bgeeexternal carotid artery1.00infobox
Insulin-like growth factor 1Bgeeiris1.00infobox
Insulin-like growth factor 1Bgeeleft lobe of liver1.00infobox
Insulin-like growth factor 1Bgeegallbladder1.00infobox
Insulin-like growth factor 1Bgeestroma of bone marrow1.00infobox
Insulin-like growth factor 1Bgeegenital tubercle1.00infobox
Insulin-like growth factor 1Bgeewhite adipose tissue1.00infobox
Insulin-like growth factor 1BioGPSMore reference expression data1.00infobox
Insulin-like growth factor 1Chr.Chromosome 12 (human)1.00infobox
Insulin-like growth factor 1Chr.Chromosome 10 (mouse)1.00infobox
Insulin-like growth factor 1DatabasesNCBI: entry; OMA: entry1.00infobox
Insulin-like growth factor 1End102,481,744 bp1.00infobox
Insulin-like growth factor 1End87,772,904 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Insulin-like growth factor 1 bring nearby vocabulary together. In this analysis, examples include Hormone, Factor and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Insulin-like growth factor 1
    • Hormone
    • Factor
    • Growth
    • Igf1
    • Insulin-like
    • Effects
    • Insulin
    • Molecular
    • System
    • Production
    • Protein
    • Receptor
  • insulin-like growth factor 1
    • Hormone
    • Insulin-like
    • Factor
    • Growth
    • Igf1
    • Effects
    • System
    • Also
    • Gh
    • Deficiency
    • Insulin
    • Liver
  • hormone
    • Gh
    • Effects
    • Insulin-like
    • Insulin
    • Deficiency
    • Production
    • Igf1
    • Receptor
    • Liver
    • Metabolic
    • Acromegaly
    • Gene
  • insulin
    • Receptor
    • Effects
    • System
    • Insulin-like
    • Metabolic
    • Chromosome
    • Human
    • Bp
    • Chr
    • Diabetes
    • Gene
    • Molecular
  • gene
    • Chromosome
    • Human
    • Bp
    • Chr
    • Band
    • Molecular
    • System
    • Protein
    • Receptor
    • Liver
    • Metabolic
    • Hormone
  • liver
    • Fibrosis
    • Metabolic
    • Disease
    • Associated
    • Chromosome
    • Human
    • Proliferation
    • Bp
    • Chr
    • Diabetes
    • Produced
    • System
  • pubertal growth spurt
    • Hormone
    • Factor
    • Igf1
    • Insulin-like
    • Gh
    • Deficiency
    • Liver
    • Effects
    • Cell
    • Production
    • Metabolic
    • Proliferation
  • cardiovascular disease
    • Fibrosis
    • Liver
    • Metabolic
    • Levels
    • Low
    • Hormone
    • Chromosome
    • Human
    • Acromegaly
    • Bp
    • Chr
    • Dairy

Connections between topic areas Semantic bridges

For Insulin-like growth factor 1, one of the stronger structural bridges in this analysis connects Insulin-like growth factor 1 with Mechanism of action. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Insulin-like growth factor 1Mechanism of action · splits 87 ⟂ 62
Insulin-like growth factor 1Overview · splits 119 ⟂ 30
Insulin-like growth factor 1Related disorders · splits 126 ⟂ 23
Insulin-like growth factor 1Causes of elevated IGF1 levels · splits 140 ⟂ 9
Insulin-like growth factor 1Use as a diagnostic test · splits 141 ⟂ 8
Insulin-like growth factor 1Health effects · splits 141 ⟂ 8
Insulin-like growth factor 1Synthesis and circulation · splits 144 ⟂ 5
Insulin-like growth factor 1Causes of reduced IGF1 levels · splits 146 ⟂ 3

Map overview Semantic statistics

Insulin-like growth factor 1

Nodes149
Edges148
Triples161
Avg. degree1.99
Density0.013423
Components1

Source & methodology

TTTA analyzes the structure around Insulin-like growth factor 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Insulin-like growth factor 1 · EN edition · Analysis: TopicsToTalkAbout

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