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P-glycoprotein

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent…

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7.6.2.1
7.6.2.2
Aliases
ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp
Band
5 A1|5 3.43 cM
Bgee
left colon · iris · Paneth cell · jejunum · crypt of lieberkuhn of small intestine
BioGPS
More reference expression data

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Overview

Species, tissue, and subcellular distribution

Function

Regulation of expression and function of P-gp in cancer cells

Clinical significance

History

Research

Single nucleotide polymorphism rs1045642

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Map overview Semantic statistics

P-glycoprotein

Nodes168
Edges167
Triples115
Avg. degree1.99
Density0.011905
Components1

How this topic connects Entity context

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P-glycoprotein

Top relations

Gene ontology · 28
P-glycoprotein → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cell surface, ceramide floppase activity, ceramide translocation, extracellular exosome, G2/M transition of mitotic cell cycle, hydrolase activity, integral component of membrane, membrane, nucleotide binding, phosphatidylcholine floppase activity, phosphatidylethanolamine flippase activity, phospholipid translocation, plasma membrane, positive regulation of anion channel activity, protein binding
related to Drug interactions · 16
P-glycoprotein → ABCB1, Common, CP, Elacridar, GT, INR, John's, Lastly, P-gp, Patients, SNP, Some, St, The, TT, Zosuquidar
related to Protein · 13
P-glycoprotein → ABC, Additional, ATP-binding, In, MD, MDR3, MsbA, N-terminal, P-gp, Pichia, The, The N-terminal, Through Molecular Dynamic
Bgee · 10
P-glycoprotein → ciliary body, crypt of lieberkuhn of small intestine, gallbladder, ileum, intestinal villus, iris, jejunum, left colon, Paneth cell, substantia nigra
RNA expression pattern · 10
P-glycoprotein → ciliary body, crypt of lieberkuhn of small intestine, gallbladder, ileum, intestinal villus, iris, jejunum, left colon, Paneth cell, substantia nigra
related to External links · 8
P-glycoprotein → ABCB1, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library
related to Gene · 3
P-glycoprotein → ABCB1, Although, RNA
7.6.2.1 · 1
P-glycoprotein → ↗
7.6.2.2 · 1
P-glycoprotein → ↗
Aliases · 1
P-glycoprotein → ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp

Important terminology Word statistics

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Important terminology

p-gp expression protein abcb1 drugs gene also cells drug substrates resistance xenobiotics cell substrate binding multidrug intestinal inhibitors many human

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
P-glycoprotein7.6.2.11.00infobox
P-glycoprotein7.6.2.21.00infobox
P-glycoproteinAliasesABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, ATP binding cassette subfamily B member 1, P-glycoprotein, P-gp, Pgp1.00infobox
P-glycoproteinBand5 A1|5 3.43 cM1.00infobox
P-glycoproteinBgeeleft colon1.00infobox
P-glycoproteinBgeeiris1.00infobox
P-glycoproteinBgeePaneth cell1.00infobox
P-glycoproteinBgeejejunum1.00infobox
P-glycoproteinBgeecrypt of lieberkuhn of small intestine1.00infobox
P-glycoproteinBgeeileum1.00infobox
P-glycoproteinBgeegallbladder1.00infobox
P-glycoproteinBgeeciliary body1.00infobox
P-glycoproteinBgeeintestinal villus1.00infobox
P-glycoproteinBgeesubstantia nigra1.00infobox
P-glycoproteinBioGPSMore reference expression data1.00infobox
P-glycoproteinChr.Chromosome 5 (mouse)1.00infobox
P-glycoproteinDatabasesNCBI: entry; OMA: entry1.00infobox
P-glycoproteinEnd8,798,575 bp1.00infobox
P-glycoproteinEnsemblENSG000000855631.00infobox
P-glycoproteinEntrez52431.00infobox
P-glycoproteinEnzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc7.6.2.1↗↗↗↗7.6.2.2↗↗↗↗1.00infobox
P-glycoproteinExternal IDsOMIM: 171050; MGI: 97570; GeneCards: ABCB11.00infobox
P-glycoproteinGene location (Mouse)Gene location (Mouse)Chr.Chromosome 5 (mouse)Band5 A1|5 3.43 cMStart8,710,077 bpEnd8,798,575 bp1.00infobox
P-glycoproteinGene ontologyATPase-coupled transmembrane transporter activity1.00infobox
P-glycoproteinGene ontologynucleotide binding1.00infobox
P-glycoproteinGene ontologytransporter activity1.00infobox
P-glycoproteinGene ontologyATPase activity1.00infobox
P-glycoproteinGene ontologyprotein binding1.00infobox
P-glycoproteinGene ontologyhydrolase activity1.00infobox
P-glycoproteinGene ontologyATP binding1.00infobox

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