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Fluconazole: History, Culture & Applications

Fluconazole, sold under the brand name Diflucan among others, is an antifungal medication used for a number of fungal infections. These include candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. It is also used to prevent candidiasis in those who are at high risk such as following organ…

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Fluconazole topic overview

The analysis highlights History, Culture and Applications as prominent areas in the source structure around Fluconazole.

Related topics
82
Source areas
9
Connected nodes
91
Extracted relationships
89
Concept neighborhoods
24
Bridge connections
91

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 24 topics
Medical uses · 16 topics
Overview · 13 topics
Side effects and mechanism · 8 topics
Pharmacology · 7 topics
Contraindications · 6 topics
Interactions · 5 topics
History and culture · 2 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D01AC15 (WHO) J02AC01 (WHO), J01RA07 (WHO)
Bioavailability
>90% (oral)
CAS Number
86386-73-4
ChEBI
CHEBI:46081

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Side effects and mechanism

History and culture

Medical uses

Contraindications

Side effects

Interactions

Pharmacology

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fluconazole connects Entity context

The extracted context around Fluconazole shows recurring relationship patterns in the source. For example, Fluconazole → Berberine, Candida, CYP2C19, CYP2C9, CYP3A4, Erythromycin, In, P450, QT, Risk Another extracted example is Fluconazole → Adverse, Common, It, Johnson, QT, Serious, Stevens, US FDA, Use. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fluconazole

Top relations

related to Interactions · 10
Fluconazole → Berberine, Candida, CYP2C19, CYP2C9, CYP3A4, Erythromycin, In, P450, QT, Risk
has effect · 9
Fluconazole → Adverse, Common, It, Johnson, QT, Serious, Stevens, US FDA, Use
related to Medical uses · 9
Fluconazole → Candida, Candidiasis, Common, Cryptococcus, Fluconazole's, It, Nakaseomyces, Pichia, While
related to history · 8
Fluconazole → Essential Medicines, In, It, Patent, Pfizer, United Kingdom, United States, World Health Organization's List
related to Pharmacokinetics · 6
Fluconazole → Bioavailability, Concentrations, Following, In, Patients, The
Legal status · 5
Fluconazole → AU: S3 (Pharmacist only) / S4, CA: ℞-only / OTC, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Pharmacodynamics · 5
Fluconazole → Cryptococcus, Like, Mammalian, P450, This
related to Combating resistance · 4
Fluconazole → Candida, One, Rising, World Health Organization
KEGG · 2
Fluconazole → C07002, D00322
related to Contraindications · 2
Fluconazole → Drink, SSRIs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

azole resistance may drugs fungal risk used candida infections pregnancy patients treatment antifungal medication include candidiasis effects qt drug therapy

Fluconazole relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around Fluconazole. Examples in this analysis include Fluconazole → 3D model (JSmol) → Interactive image and Fluconazole → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Fluconazole3D model (JSmol)Interactive image1.00infobox
FluconazoleAHFS/Drugs.comMonograph1.00infobox
FluconazoleATC codeD01AC15 (WHO) J02AC01 (WHO), J01RA07 (WHO)1.00infobox
FluconazoleBioavailability>90% (oral)1.00infobox
FluconazoleCAS Number86386-73-41.00infobox
FluconazoleChEBICHEBI:460811.00infobox
FluconazoleChEMBLChEMBL1061.00infobox
FluconazoleChemSpider32481.00infobox
FluconazoleCompTox Dashboard (EPA)DTXSID30206271.00infobox
FluconazoleDrugBankDB001961.00infobox
FluconazoleECHA InfoCard100.156.1331.00infobox
FluconazoleElimination half-life30 hours (range 20–50 hours)1.00infobox
FluconazoleExcretionKidney 61–88%1.00infobox
FluconazoleFormulaC13H12F2N6O1.00infobox
FluconazoleKEGGD003221.00infobox
FluconazoleKEGGC070021.00infobox
FluconazoleLegal statusAU: S3 (Pharmacist only) / S41.00infobox
FluconazoleLegal statusCA: ℞-only / OTC1.00infobox
FluconazoleLegal statusUK: POM (Prescription only)1.00infobox
FluconazoleLegal statusUS: ℞-only1.00infobox
FluconazoleLegal statusEU: Rx-only1.00infobox
FluconazoleLicense dataUS DailyMed: Fluconazole1.00infobox
FluconazoleMedlinePlusa6900021.00infobox
FluconazoleMelting point139 °C (282 °F)1.00infobox
FluconazoleMetabolismLiver 11%1.00infobox
FluconazoleMolar mass306.277 g·mol−11.00infobox
FluconazolePregnancy categoryAU: D1.00infobox
FluconazoleProtein binding11–12%1.00infobox
FluconazolePubChem CID33651.00infobox
FluconazoleRoutes of administrationBy mouth, intravenous, topical1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fluconazole bring nearby vocabulary together. In this analysis, examples include Medication, Fungal and May. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fluconazole
    • Medication
    • Fungal
    • May
    • Resistance
    • Metabolism
    • Us
    • Due
    • Oral
    • Serious
    • Antifungal
    • Pregnancy
    • Used
  • fluconazole
    • Medication
    • Fungal
    • May
    • Resistance
    • Metabolism
    • Us
    • Due
    • Oral
    • Serious
    • Antifungal
    • Pregnancy
    • Used
  • azole antifungal
    • Medication
    • Drug
    • Drugs
    • Therapy
    • Candida
    • Infections
    • Name
    • Resistance
    • Azole
    • Others
    • Pregnancy
    • Treatment
  • azole antifungals
    • Triazole
    • Drug
    • Drugs
    • Treatment
    • Resistance
    • Therapy
    • People
    • Pregnancy
    • Patients
    • May
    • Infections
    • Used
  • antifungal resistance
    • Medication
    • Drugs
    • Therapy
    • Candida
    • Infections
    • Azole
    • Name
    • Us
    • Drug
    • Others
    • Resistance
    • Triazole
  • azole
    • Drug
    • Drugs
    • Resistance
    • Therapy
    • Pregnancy
    • Treatment
    • Patients
    • May
    • Fluconazole
    • Liver
    • Triazole
    • Us
  • birth defects
    • Risk
    • Pregnancy
    • Candidiasis
    • Following
    • Liver
    • May
    • Us
    • Including
    • Interval
    • Oral
    • Serious
    • Use
  • increased liver enzymes
    • Side
    • Include
    • Us
    • Serious
    • Qt
    • Pregnancy
    • Name
    • Metabolism
    • Mouth
    • Others
    • May
    • Including

Connections between topic areas Semantic bridges

For Fluconazole, one of the stronger structural bridges in this analysis connects Fluconazole with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Fluconazole — Side effects · splits 67 ⟂ 25
Fluconazole — Medical uses · splits 75 ⟂ 17
Fluconazole — Overview · splits 78 ⟂ 14
Fluconazole — Side effects and mechanism · splits 83 ⟂ 9
Fluconazole — Pharmacology · splits 84 ⟂ 8
Fluconazole — Contraindications · splits 85 ⟂ 7
Fluconazole — Interactions · splits 86 ⟂ 6
Fluconazole — History and culture · splits 89 ⟂ 3

Map overview Semantic statistics

Fluconazole

Nodes92
Edges91
Triples89
Avg. degree1.98
Density0.021739
Components1

Source & methodology

TTTA analyzes the structure around Fluconazole to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fluconazole · EN edition · Analysis: TopicsToTalkAbout

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