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Fluconazole

Fluconazole, sold under the brand name Diflucan among others, is an antifungal medication used for a number of fungal infections. These include candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. It is also used to prevent candidiasis in those who are at high risk such as following organ…

History, Culture & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
D01AC15 (WHO) J02AC01 (WHO), J01RA07 (WHO)
Bioavailability
>90% (oral)
CAS Number
86386-73-4
ChEBI
CHEBI:46081

Topics to explore

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Overview

Side effects and mechanism

History and culture

Medical uses

Contraindications

Side effects

Interactions

Pharmacology

History

Advanced semantic analysis

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Map overview Semantic statistics

Fluconazole

Nodes92
Edges91
Triples89
Avg. degree1.98
Density0.021739
Components1

How this topic connects Entity context

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Fluconazole

Top relations

related to Interactions · 10
Fluconazole → Berberine, Candida, CYP2C19, CYP2C9, CYP3A4, Erythromycin, In, P450, QT, Risk
has effect · 9
Fluconazole → Adverse, Common, It, Johnson, QT, Serious, Stevens, US FDA, Use
related to Medical uses · 9
Fluconazole → Candida, Candidiasis, Common, Cryptococcus, Fluconazole's, It, Nakaseomyces, Pichia, While
related to history · 8
Fluconazole → Essential Medicines, In, It, Patent, Pfizer, United Kingdom, United States, World Health Organization's List
related to Pharmacokinetics · 6
Fluconazole → Bioavailability, Concentrations, Following, In, Patients, The
Legal status · 5
Fluconazole → AU: S3 (Pharmacist only) / S4, CA: ℞-only / OTC, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Pharmacodynamics · 5
Fluconazole → Cryptococcus, Like, Mammalian, P450, This
related to Combating resistance · 4
Fluconazole → Candida, One, Rising, World Health Organization
KEGG · 2
Fluconazole → C07002, D00322
related to Contraindications · 2
Fluconazole → Drink, SSRIs

Important terminology Word statistics

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Important terminology

azole resistance may drugs fungal risk used candida infections pregnancy patients treatment antifungal medication include candidiasis effects qt drug therapy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Fluconazole3D model (JSmol)Interactive image1.00infobox
FluconazoleAHFS/Drugs.comMonograph1.00infobox
FluconazoleATC codeD01AC15 (WHO) J02AC01 (WHO), J01RA07 (WHO)1.00infobox
FluconazoleBioavailability>90% (oral)1.00infobox
FluconazoleCAS Number86386-73-41.00infobox
FluconazoleChEBICHEBI:460811.00infobox
FluconazoleChEMBLChEMBL1061.00infobox
FluconazoleChemSpider32481.00infobox
FluconazoleCompTox Dashboard (EPA)DTXSID30206271.00infobox
FluconazoleDrugBankDB001961.00infobox
FluconazoleECHA InfoCard100.156.1331.00infobox
FluconazoleElimination half-life30 hours (range 20–50 hours)1.00infobox
FluconazoleExcretionKidney 61–88%1.00infobox
FluconazoleFormulaC13H12F2N6O1.00infobox
FluconazoleKEGGD003221.00infobox
FluconazoleKEGGC070021.00infobox
FluconazoleLegal statusAU: S3 (Pharmacist only) / S41.00infobox
FluconazoleLegal statusCA: ℞-only / OTC1.00infobox
FluconazoleLegal statusUK: POM (Prescription only)1.00infobox
FluconazoleLegal statusUS: ℞-only1.00infobox
FluconazoleLegal statusEU: Rx-only1.00infobox
FluconazoleLicense dataUS DailyMed: Fluconazole1.00infobox
FluconazoleMedlinePlusa6900021.00infobox
FluconazoleMelting point139 °C (282 °F)1.00infobox
FluconazoleMetabolismLiver 11%1.00infobox
FluconazoleMolar mass306.277 g·mol−11.00infobox
FluconazolePregnancy categoryAU: D1.00infobox
FluconazoleProtein binding11–12%1.00infobox
FluconazolePubChem CID33651.00infobox
FluconazoleRoutes of administrationBy mouth, intravenous, topical1.00infobox

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