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EC50

Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. More simply, EC50 can be defined as the concentration required to obtain a 50% effect and may be also written as 50. It is commonly used…

Measurement, Calculation of EC50 & Relation to the Hill Equation

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Calculation of EC50

LigandSigmoidalInflection pointAgonistHalf maximal effective concentration
5 related topics

Relation to the Hill Equation

Hill coefficientPoint of inflectionDose response curvesLogistic function
4 related topics

Relation to affinity and efficacy

AffinityEfficacy
2 related topics

Limitations

Toxicity
1 related topics

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Overview

Calculation of EC50

Relation to affinity and efficacy

Relation to the Hill Equation

Limitations

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Map overview Semantic statistics

EC50

Nodes24
Edges23
Triples19
Avg. degree1.92
Density0.083333
Components1

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EC50

Top relations

related to Calculation of EC50 · 7
EC50 → At, Biological, EC90, Emax, The, The EC10, While
related to Affinity · 5
EC50 → Affinity, Faster, Kd, The EC50, While
related to Limitations · 4
EC50 → Furthermore, The, Therefore, This
related to Relation to the Hill Equation · 2
EC50 → Hill, The EC50
is a · 1
EC50 → measure of concentration

Important terminology Word statistics

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Important terminology

response concentration drug curve measure 50 dose effect potency affinity agonist receptor time maximal exposure represents also ic50 function binding

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EC50is ameasure of concentration0.90text
EC50related to AffinityAffinity0.60section
EC50related to AffinityFaster0.60section
EC50related to AffinityThe EC500.60section
EC50related to AffinityKd0.60section
EC50related to AffinityWhile0.60section
EC50related to Calculation of EC50Biological0.60section
EC50related to Calculation of EC50The0.60section
EC50related to Calculation of EC50While0.60section
EC50related to Calculation of EC50At0.60section
EC50related to Calculation of EC50Emax0.60section
EC50related to Calculation of EC50The EC100.60section

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