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Ticagrelor

Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y12 receptor. The drug is produced by AstraZeneca.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B01AC24 (WHO)
Bioavailability
36%
CAS Number
274693-27-5 Y
ChEMBL
ChEMBL398435 N

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Overview

Medical uses

Adverse effects

Interactions

Pharmacology

Chemistry

Research

Advanced semantic analysis

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Map overview Semantic statistics

Ticagrelor

Nodes59
Edges58
Triples92
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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Ticagrelor

Top relations

related to Interactions · 16
Ticagrelor → AR-C124910XX, Current, CYP2C9, CYP3A4, However, Inhibitors, John's, Levels, O-deethylation, P-glycoprotein, P-gp, St, The, There, This, While
has effect · 10
Ticagrelor → ACS, Allergic, CAD, Caution, Discontinuation, Dyspnoea, Furthermore, People, The, Ventricular
related to Pharmacokinetics · 9
Ticagrelor → AR-C124910XX, Asian, Caucasians, CYP3A4, In Japanese, Plasma, The, These, They
related to Mechanism of action · 8
Ticagrelor → ADP, CYP2C19, Han Chinese CYP2C19, In, Like, Moreover, P2Y12, TIA
related to Research · 8
Ticagrelor → AstraZeneca, BMJ, FDA, In, It, NEJM, PLATO, The
Legal status · 4
Ticagrelor → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, US: ℞-only
related to Contraindications · 3
Ticagrelor → Contraindications, CYP3A4, P-450
related to Medical uses · 3
Ticagrelor → EU, In, US
related to Chemistry · 2
Ticagrelor → Biopharmaceutics Classification System, The
3D model (JSmol) · 1
Ticagrelor → Interactive image

Important terminology Word statistics

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Important terminology

people clopidogrel risk stroke acute coronary bleeding effects trial adverse events syndrome cyp3a4 increased evidence used use blood hepatic therapy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ticagrelor3D model (JSmol)Interactive image1.00infobox
TicagrelorAHFS/Drugs.comMonograph1.00infobox
TicagrelorATC codeB01AC24 (WHO)1.00infobox
TicagrelorBioavailability36%1.00infobox
TicagrelorCAS Number274693-27-5 Y1.00infobox
TicagrelorChEMBLChEMBL398435 N1.00infobox
TicagrelorChemSpider8047109 N1.00infobox
TicagrelorCompTox Dashboard (EPA)DTXSID9010093371.00infobox
TicagrelorDrugBankDB08816 Y1.00infobox
TicagrelorECHA InfoCard100.114.7461.00infobox
TicagrelorElimination half-life7 hrs (ticagrelor), 8.5 hrs (active metabolite AR-C124910XX)1.00infobox
TicagrelorExcretionBile duct1.00infobox
TicagrelorFormulaC23H28F2N6O4S1.00infobox
TicagrelorIUPHAR/BPS17651.00infobox
TicagrelorKEGGD09017 Y1.00infobox
TicagrelorLegal statusAU: S4 (Prescription only)1.00infobox
TicagrelorLegal statusCA: ℞-only1.00infobox
TicagrelorLegal statusUS: ℞-only1.00infobox
TicagrelorLegal statusEU: Rx-only1.00infobox
TicagrelorLicense dataUS DailyMed: Ticagrelor1.00infobox
TicagrelorMedlinePlusa6110501.00infobox
TicagrelorMetabolismLiver (CYP3A4)1.00infobox
TicagrelorMolar mass522.57 g·mol−11.00infobox
TicagrelorOther namesAZD-61401.00infobox
TicagrelorPregnancy categoryAU: B11.00infobox
TicagrelorProtein binding>99.7%1.00infobox
TicagrelorPubChem CID98714191.00infobox
TicagrelorRoutes of administrationBy mouth1.00infobox
TicagrelorTrade namesBrilinta, Brilique, others1.00infobox
TicagrelorUNIIGLH0314RVC1.00infobox

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