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TICAM1: Research, Structure & Areas of research

TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.

Language: English [EN]
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TICAM1 topic overview

The analysis highlights Research, Structure and Areas of research as prominent areas in the source structure around TICAM1.

Related topics
13
Source areas
3
Connected nodes
16
Extracted relationships
128
Concept neighborhoods
6
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 5 topics
Areas of research · 4 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M1X, 2M63, 3RC4, 4BSX, 4C0M, 5JEL
Band
19p13.3 · 17|17 D
Bgee
buccal mucosa cell · granulocyte · mucosa of transverse colon · parotid gland · gastrocnemius muscle
BioGPS
n/a
Chr.
Chromosome 19 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Areas of research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TICAM1 connects Entity context

The extracted context around TICAM1 shows recurring relationship patterns in the source. For example, TICAM1 → apoptotic process, apoptotic signaling pathway, autophagosome, cellular response to lipopolysaccharide, cytoplasmic vesicle, cytosol, defense response to virus, endosome membrane, I-kappaB kinase/NF-kappaB signaling, immune system process, inflammatory response, innate immune response, lipopolysaccharide-mediated signaling pathway, macrophage activation involved in immune response, MyD88-independent toll-like receptor signaling pathway, necroptosis, negative regulation of MyD88-independent toll-like receptor signaling pathway, positive regulation of autophagy, positive regulation of B cell activation, positive regulation of B cell proliferation Another extracted example is TICAM1 → ascending aorta, body of stomach, buccal mucosa cell, colon, duodenum, epithelium of stomach, female urethra, gastrocnemius muscle, granulocyte, ileum, jejunum, lacrimal gland, mucosa of transverse colon, muscle of thigh, parotid gland, right lobe of liver, skin of abdomen, urethra, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

TICAM1

Top relations

Gene ontology · 38
TICAM1 → apoptotic process, apoptotic signaling pathway, autophagosome, cellular response to lipopolysaccharide, cytoplasmic vesicle, cytosol, defense response to virus, endosome membrane, I-kappaB kinase/NF-kappaB signaling, immune system process, inflammatory response, innate immune response, lipopolysaccharide-mediated signaling pathway, macrophage activation involved in immune response, MyD88-independent toll-like receptor signaling pathway, necroptosis, negative regulation of MyD88-independent toll-like receptor signaling pathway, positive regulation of autophagy, positive regulation of B cell activation, positive regulation of B cell proliferation
Bgee · 19
TICAM1 → ascending aorta, body of stomach, buccal mucosa cell, colon, duodenum, epithelium of stomach, female urethra, gastrocnemius muscle, granulocyte, ileum, jejunum, lacrimal gland, mucosa of transverse colon, muscle of thigh, parotid gland, right lobe of liver, skin of abdomen, urethra, yolk sac
RNA expression pattern · 19
TICAM1 → ascending aorta, body of stomach, buccal mucosa cell, colon, duodenum, epithelium of stomach, female urethra, gastrocnemius muscle, granulocyte, ileum, jejunum, lacrimal gland, mucosa of transverse colon, muscle of thigh, parotid gland, right lobe of liver, skin of abdomen, urethra, yolk sac
related to Structure · 15
TICAM1 → Cells, Curiously, Destruction, IRAK, MyD88, NF-κB, RIP, RIP1, RIP3, This, Three TRAF-binding, TLR3, TLR4, TLRs, TRAF6
related to Areas of research · 7
TICAM1 → Better, Experiments, Investigations, It, The, TICAM1-deficient, TLR
related to External links · 7
TICAM1 → KEGG, KO, Medicine Medical Subject Headings, MeSH, National Library, Reference, Toll-like
Band · 2
TICAM1 → 17|17 D, 19p13.3
Chr. · 2
TICAM1 → Chromosome 17 (mouse), Chromosome 19 (human)
End · 2
TICAM1 → 4,831,712 bp, 56,583,786 bp
Aliases · 1
TICAM1 → TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

signaling bp human domain immune chr band tlrs toll-like response chromosome 19 receptors cascade activation gene tir downstream adapter protein

TICAM1 relationships Subject–Predicate–Object triples

TTTA extracted 128 structured relationships around TICAM1. Examples in this analysis include TICAM1 → Aliases → TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1 and TICAM1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M1X, 2M63, 3RC4, 4BSX, 4C0M, 5JEL. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TICAM1AliasesTICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 11.00infobox
TICAM1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M1X, 2M63, 3RC4, 4BSX, 4C0M, 5JEL1.00infobox
TICAM1Band19p13.31.00infobox
TICAM1Band17|17 D1.00infobox
TICAM1Bgeebuccal mucosa cell1.00infobox
TICAM1Bgeegranulocyte1.00infobox
TICAM1Bgeemucosa of transverse colon1.00infobox
TICAM1Bgeeparotid gland1.00infobox
TICAM1Bgeegastrocnemius muscle1.00infobox
TICAM1Bgeeascending aorta1.00infobox
TICAM1Bgeeskin of abdomen1.00infobox
TICAM1Bgeemuscle of thigh1.00infobox
TICAM1Bgeebody of stomach1.00infobox
TICAM1Bgeeright lobe of liver1.00infobox
TICAM1Bgeejejunum1.00infobox
TICAM1Bgeeileum1.00infobox
TICAM1Bgeeduodenum1.00infobox
TICAM1Bgeelacrimal gland1.00infobox
TICAM1Bgeeepithelium of stomach1.00infobox
TICAM1Bgeeurethra1.00infobox
TICAM1Bgeefemale urethra1.00infobox
TICAM1Bgeeyolk sac1.00infobox
TICAM1Bgeecolon1.00infobox
TICAM1BioGPSn/a1.00infobox
TICAM1Chr.Chromosome 19 (human)1.00infobox
TICAM1Chr.Chromosome 17 (mouse)1.00infobox
TICAM1DatabasesNCBI: entry; OMA: entry1.00infobox
TICAM1End4,831,712 bp1.00infobox
TICAM1End56,583,786 bp1.00infobox
TICAM1EnsemblENSG000001276661.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TICAM1 bring nearby vocabulary together. In this analysis, examples include Activation, Gene and Pathways. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TICAM1
    • Activation
    • Gene
    • Pathways
    • Protein
    • Human
    • Trif
    • Location
    • Receptor
    • Tir
    • Chromosome
    • Pathway
    • Tlrs
  • ticam1
    • Activation
    • Gene
    • Pathways
    • Protein
    • Human
    • Trif
    • Location
    • Receptor
    • Tir
    • Chromosome
    • Pathway
    • Tlrs
  • toll-like receptors
    • Recognize
    • Receptor
    • Tlrs
    • Toll-like
    • Immune
    • Pathway
    • Response
    • Cytokines
    • Expression
    • Inflammatory
    • Specific
    • Trif
  • myd88
    • Cellular
    • Expression
    • Inflammatory
    • Mouse
    • Location
    • Receptor
    • Signaling
    • Band
    • Chromosome
    • Gene
    • Pathway
    • Pathways
  • adapter
    • Adaptor
    • Cascades
    • Containing
    • Molecule
    • Myd88
    • Trif
    • Cascade
    • Receptors
    • Tir
    • Activation
    • Tlrs
    • Toll-like
  • cytokines
    • Immune
    • Expression
    • Inflammatory
    • Recognize
    • Downstream
    • Receptors
    • Domain
    • Signaling
    • Ticam1

Connections between topic areas Semantic bridges

For TICAM1, one of the stronger structural bridges in this analysis connects TICAM1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TICAM1Overview · splits 11 ⟂ 6
TICAM1Structure · splits 12 ⟂ 5
TICAM1Areas of research · splits 12 ⟂ 5

Map overview Semantic statistics

TICAM1

Nodes17
Edges16
Triples128
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around TICAM1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Structure & Areas of research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TICAM1 · EN edition · Analysis: TopicsToTalkAbout

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