CD86

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CD86 topic overview

The analysis highlights Role in co-stimulation, T-cell activation and inhibition, Structure and Overview as prominent areas in the source structure around CD86.

Related topics: 50
Source areas: 5
Connected nodes: 55
Extracted relationships: 165
Concept neighborhoods: 23
Bridge connections: 55

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 16 topics

Role in co-stimulation, T-cell activation and inhibition · 15 topics

Structure · 8 topics

Role in pathology · 6 topics

Treg mediation · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I85, 1NCN
Band: 3q13.33 · 16 B3|16 25.72 cM
Bgee: monocyte · granulocyte · appendix · testicle · blood
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 16 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

B7 family B7 (protein)
KDa Dalton (unit)
Glycoprotein
Amino acids Amino acid
Ligand binding domain
Ig-like extracellular domains Immunoglobulin domain
Transmembrane region
Monocytes Monocyte

Role in co-stimulation, T-cell activation and inhibition

CD28
Naïve T cells Naive T cell
CTLA-4
T cell receptor T-cell receptor
Major histocompatibility complex (MHC) class II molecules MHC class II
Anergy Clonal anergy
IL-2 Interleukin 2
Mitogen-activated protein kinase
Nf-κB
CD40L CD154
IL-21 Interleukin 21
IL-21R Interleukin-21 receptor
CD4+CD25+ Tregulatory cell Regulatory T cell
IDO Indoleamine 2,3-dioxygenase
Tryptophan

Treg mediation

Role in pathology

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD86 connects Entity context

The extracted context around CD86 shows recurring relationship patterns in the source. For example, CD86 → adaptive immune response, ageing, B cell activation, cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to metal ion, coreceptor activity, cytokine-mediated signaling pathway, defense response to virus, external side of plasma membrane, extracellular exosome, immune response, immune system process, integral component of membrane, intracellular membrane-bounded organelle, membrane, myeloid dendritic cell differentiation Another extracted example is CD86 → APCs, B7, CD28, CD40, CD80, CD80/CD86, CTLA-4, DC, Downregulation, Due, For, II, It, MHC, Pathways, Regulatory, Sagurachi, Since CTLA-4, T-cell, Their. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 46

CD86 → adaptive immune response, ageing, B cell activation, cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to metal ion, coreceptor activity, cytokine-mediated signaling pathway, defense response to virus, external side of plasma membrane, extracellular exosome, immune response, immune system process, integral component of membrane, intracellular membrane-bounded organelle, membrane, myeloid dendritic cell differentiation

related to Treg mediation · 22

CD86 → APCs, B7, CD28, CD40, CD80, CD80/CD86, CTLA-4, DC, Downregulation, Due, For, II, It, MHC, Pathways, Regulatory, Sagurachi, Since CTLA-4, T-cell, Their

Bgee · 17

CD86 → appendix, blood, gallbladder, granulocyte, lumbar spinal ganglion, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, rectum, right lung, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus

RNA expression pattern · 17

related to Role in co-stimulation, T-cell activation and inhibition · 14

CD86 → Binding, CD152, CD28, CD80, CD80/CD86, CTLA-4, II, MHC, T-cell, T-lymphocyte, TCR, The, These, To

related to Role in pathology · 13

CD86 → AHR, B-cell, Bronchial Astma, CD80, CD80/CD86, In, Roles, Selective, Several, Since, Staphylococcus, The, Treg

related to Structure · 8

CD86 → At, B-cells, B7, Both CD80, CD80, Ig-like, It, They

Band · 2

CD86 → 16 B3|16 25.72 cM, 3q13.33

Chr. · 2

CD86 → Chromosome 16 (mouse), Chromosome 3 (human)

End · 2

CD86 → 122,121,139 bp, 36,486,443 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd80 ctla-4 cell cells cd28 activation also costimulatory human protein bp gene chr band interaction signals chromosome treg surface differentiation

CD86 relationships Subject–Predicate–Object triples

TTTA extracted 165 structured relationships around CD86. Examples in this analysis include CD86 → Aliases → CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule and CD86 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I85, 1NCN. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD86	Aliases	CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule	1.00	infobox
CD86	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I85, 1NCN	1.00	infobox
CD86	Band	3q13.33	1.00	infobox
CD86	Band	16 B3\|16 25.72 cM	1.00	infobox
CD86	Bgee	monocyte	1.00	infobox
CD86	Bgee	granulocyte	1.00	infobox
CD86	Bgee	appendix	1.00	infobox
CD86	Bgee	testicle	1.00	infobox
CD86	Bgee	blood	1.00	infobox
CD86	Bgee	lymph node	1.00	infobox
CD86	Bgee	gallbladder	1.00	infobox
CD86	Bgee	spleen	1.00	infobox
CD86	Bgee	right lung	1.00	infobox
CD86	Bgee	rectum	1.00	infobox
CD86	Bgee	lumbar spinal ganglion	1.00	infobox
CD86	Bgee	mesenteric lymph nodes	1.00	infobox
CD86	Bgee	thymus	1.00	infobox
CD86	Bgee	stroma of bone marrow	1.00	infobox
CD86	Bgee	subcutaneous adipose tissue	1.00	infobox
CD86	Bgee	Paneth cell	1.00	infobox
CD86	Bgee	lumbar subsegment of spinal cord	1.00	infobox
CD86	BioGPS	More reference expression data	1.00	infobox
CD86	Chr.	Chromosome 3 (human)	1.00	infobox
CD86	Chr.	Chromosome 16 (mouse)	1.00	infobox
CD86	Databases	NCBI: entry; OMA: entry	1.00	infobox
CD86	End	122,121,139 bp	1.00	infobox
CD86	End	36,486,443 bp	1.00	infobox
CD86	Ensembl	ENSG00000114013	1.00	infobox
CD86	Entrez	942	1.00	infobox
CD86	External IDs	OMIM: 601020; MGI: 101773; GeneCards: CD86	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD86 bring nearby vocabulary together. In this analysis, examples include Cd80, Cd28 and Ctla-4. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD86
- Cd80
- Cd28
- Ctla-4
- Cells
- Activation
- Cell
- Surface
- Costimulatory
- Protein
- Interaction
- Response
- T-cell
cd86
- Cd80
- Cd28
- Ctla-4
- Cells
- Activation
- Cell
- Surface
- Costimulatory
- Protein
- Interaction
- Response
- T-cell
dendritic cells
- Expressed
- Activated
- Differentiation
- Protein
- Ctla-4
- External
- Cd80
- Anergy
- Antigen-presenting
- Known
- Signal
- Costimulatory
antigen-presenting cells
- Expressed
- Ctla-4
- Cd80
- Dendritic
- Known
- Costimulatory
- Activated
- T-cell
- Differentiation
- Ligand
- Protein
- Surface
cd80
- Cd86
- Cd28
- Ctla-4
- Costimulatory
- Cells
- Signals
- Interaction
- Activation
- Surface
- Cell
- Anergy
- Binding
t cell
- Surface
- Signals
- Interaction
- Costimulatory
- Negative
- Ligand
- Cd28
- Expressed
- Signal
- Activated
- Binding
- Ctla-4
gene
- Location
- Human
- Bp
- Chr
- Chromosome
- External
- Band
- Protein
- Anergy
- Signal
- Activated
- Binding
ligand binding domain
- External
- Anergy
- Dendritic
- Expressed
- Signal
- Activated
- Cd28
- Immune
- Location
- Negative
- Regulation
- Response

Connections between topic areas Semantic bridges

For CD86, one of the stronger structural bridges in this analysis connects CD86 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD86 — Overview · splits 39 ⟂ 17

CD86 — Role in co-stimulation, T-cell activation and inhibition · splits 40 ⟂ 16

CD86 — Structure · splits 47 ⟂ 9

CD86 — Role in pathology · splits 49 ⟂ 7

CD86 — Treg mediation · splits 50 ⟂ 6

Map overview Semantic statistics

CD86

Nodes56

Edges55

Triples165

Avg. degree1.96

Density0.035714

Components1

Source & methodology

TTTA analyzes the structure around CD86 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in co-stimulation, T-cell activation and inhibition, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD86 · EN edition · Analysis: TopicsToTalkAbout