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CD86

Cluster of differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound…

Role in co-stimulation, T-cell activation and inhibition, Structure & Overview

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Aliases
CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I85, 1NCN
Band
3q13.33 · 16 B3|16 25.72 cM
Bgee
monocyte · granulocyte · appendix · testicle · blood
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Overview

Structure

Role in co-stimulation, T-cell activation and inhibition

Treg mediation

Role in pathology

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Map overview Semantic statistics

CD86

Nodes56
Edges55
Triples165
Avg. degree1.96
Density0.035714
Components1

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CD86

Top relations

Gene ontology · 46
CD86 → adaptive immune response, ageing, B cell activation, cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cellular response to metal ion, coreceptor activity, cytokine-mediated signaling pathway, defense response to virus, external side of plasma membrane, extracellular exosome, immune response, immune system process, integral component of membrane, intracellular membrane-bounded organelle, membrane, myeloid dendritic cell differentiation
related to Treg mediation · 22
CD86 → APCs, B7, CD28, CD40, CD80, CD80/CD86, CTLA-4, DC, Downregulation, Due, For, II, It, MHC, Pathways, Regulatory, Sagurachi, Since CTLA-4, T-cell, Their
Bgee · 17
CD86 → appendix, blood, gallbladder, granulocyte, lumbar spinal ganglion, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, rectum, right lung, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus
RNA expression pattern · 17
CD86 → appendix, blood, gallbladder, granulocyte, lumbar spinal ganglion, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, rectum, right lung, spleen, stroma of bone marrow, subcutaneous adipose tissue, testicle, thymus
related to Role in co-stimulation, T-cell activation and inhibition · 14
CD86 → Binding, CD152, CD28, CD80, CD80/CD86, CTLA-4, II, MHC, T-cell, T-lymphocyte, TCR, The, These, To
related to Role in pathology · 13
CD86 → AHR, B-cell, Bronchial Astma, CD80, CD80/CD86, In, Roles, Selective, Several, Since, Staphylococcus, The, Treg
related to Structure · 8
CD86 → At, B-cells, B7, Both CD80, CD80, Ig-like, It, They
Band · 2
CD86 → 16 B3|16 25.72 cM, 3q13.33
Chr. · 2
CD86 → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
CD86 → 122,121,139 bp, 36,486,443 bp

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Important terminology

cd80 ctla-4 cell cells cd28 activation also costimulatory human protein bp gene chr band interaction signals chromosome treg surface differentiation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD86AliasesCD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule1.00infobox
CD86Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I85, 1NCN1.00infobox
CD86Band3q13.331.00infobox
CD86Band16 B3|16 25.72 cM1.00infobox
CD86Bgeemonocyte1.00infobox
CD86Bgeegranulocyte1.00infobox
CD86Bgeeappendix1.00infobox
CD86Bgeetesticle1.00infobox
CD86Bgeeblood1.00infobox
CD86Bgeelymph node1.00infobox
CD86Bgeegallbladder1.00infobox
CD86Bgeespleen1.00infobox
CD86Bgeeright lung1.00infobox
CD86Bgeerectum1.00infobox
CD86Bgeelumbar spinal ganglion1.00infobox
CD86Bgeemesenteric lymph nodes1.00infobox
CD86Bgeethymus1.00infobox
CD86Bgeestroma of bone marrow1.00infobox
CD86Bgeesubcutaneous adipose tissue1.00infobox
CD86BgeePaneth cell1.00infobox
CD86Bgeelumbar subsegment of spinal cord1.00infobox
CD86BioGPSMore reference expression data1.00infobox
CD86Chr.Chromosome 3 (human)1.00infobox
CD86Chr.Chromosome 16 (mouse)1.00infobox
CD86DatabasesNCBI: entry; OMA: entry1.00infobox
CD86End122,121,139 bp1.00infobox
CD86End36,486,443 bp1.00infobox
CD86EnsemblENSG000001140131.00infobox
CD86Entrez9421.00infobox
CD86External IDsOMIM: 601020; MGI: 101773; GeneCards: CD861.00infobox

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