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CD80

The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with…

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Aliases
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L
Band
3q13.33 · 16 B4|16 26.86 cM
Bgee
testicle · lower lobe of lung · pancreatic ductal cell · tibialis anterior muscle · appendix
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Map overview Semantic statistics

CD80

Nodes77
Edges76
Triples137
Avg. degree1.97
Density0.025974
Components1

How this topic connects Entity context

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CD80

Top relations

Gene ontology · 31
CD80 → cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to lipopolysaccharide, coreceptor activity, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, integral component of membrane, intracellular anatomical structure, intracellular signal transduction, membrane, negative regulation of T cell proliferation, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of alpha-beta T cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein kinase B signaling, positive regulation of signal transduction
Bgee · 19
CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle
RNA expression pattern · 19
CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle
related to Structure · 18
CD80 → AA, APCs, B-cells, B7, Both, C2-type, CD28, CD86, CTLA-4, DC, Ig, Ig-like, It, Moreover, T-cells, The Ig-like, These, V-type
related to Function · 11
CD80 → APCs, B-cells, CD28, CTLA-4, However, In, Interaction, T-cell, T-cells, These, This
related to External links · 8
CD80 → Human CD80, Overview, P33681, PDB, PDBe-KB, T-lymphocyte, UCSC Genome Browser, UniProt
related to Clinical significance · 6
CD80 → HIV, Natural Killer, Others, T-cell, T-cells, The
Band · 2
CD80 → 16 B4|16 26.86 cM, 3q13.33
Chr. · 2
CD80 → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
CD80 → 119,559,614 bp, 38,316,697 bp

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Important terminology

cd28 t-cells also ctla-4 cd86 human interaction t-cell protein bp activation immune cells binding receptor chr b7 band chromosome cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD80AliasesCD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule1.00infobox
CD80Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L1.00infobox
CD80Band3q13.331.00infobox
CD80Band16 B4|16 26.86 cM1.00infobox
CD80Bgeetesticle1.00infobox
CD80Bgeelower lobe of lung1.00infobox
CD80Bgeepancreatic ductal cell1.00infobox
CD80Bgeetibialis anterior muscle1.00infobox
CD80Bgeeappendix1.00infobox
CD80Bgeelymph node1.00infobox
CD80Bgeespleen1.00infobox
CD80Bgeeupper lobe of lung1.00infobox
CD80Bgeeupper lobe of left lung1.00infobox
CD80Bgeemucosa of ileum1.00infobox
CD80Bgeegranulocyte1.00infobox
CD80Bgeestroma of bone marrow1.00infobox
CD80Bgeeembryo1.00infobox
CD80Bgeethymus1.00infobox
CD80Bgeesternocleidomastoid muscle1.00infobox
CD80Bgeevastus lateralis muscle1.00infobox
CD80Bgeeblood1.00infobox
CD80Bgeeendothelial cell of lymphatic vessel1.00infobox
CD80Bgeemajor salivary gland1.00infobox
CD80BioGPSn/a1.00infobox
CD80Chr.Chromosome 3 (human)1.00infobox
CD80Chr.Chromosome 16 (mouse)1.00infobox
CD80DatabasesNCBI: entry; OMA: entry1.00infobox
CD80End119,559,614 bp1.00infobox
CD80End38,316,697 bp1.00infobox
CD80EnsemblENSG000001215941.00infobox

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