Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CD80: Function, Structure & Clinical significance

The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

CD80 topic overview

The analysis highlights Function, Structure and Clinical significance as prominent areas in the source structure around CD80.

Related topics
72
Source areas
4
Connected nodes
76
Extracted relationships
137
Concept neighborhoods
22
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 42 topics
Structure · 16 topics
Clinical significance · 8 topics
Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L
Band
3q13.33 · 16 B4|16 26.86 cM
Bgee
testicle · lower lobe of lung · pancreatic ductal cell · tibialis anterior muscle · appendix
BioGPS
n/a
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD80 connects Entity context

The extracted context around CD80 shows recurring relationship patterns in the source. For example, CD80 → cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to lipopolysaccharide, coreceptor activity, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, integral component of membrane, intracellular anatomical structure, intracellular signal transduction, membrane, negative regulation of T cell proliferation, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of alpha-beta T cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein kinase B signaling, positive regulation of signal transduction Another extracted example is CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD80

Top relations

Gene ontology · 31
CD80 → cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to lipopolysaccharide, coreceptor activity, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, integral component of membrane, intracellular anatomical structure, intracellular signal transduction, membrane, negative regulation of T cell proliferation, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of alpha-beta T cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein kinase B signaling, positive regulation of signal transduction
Bgee · 19
CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle
RNA expression pattern · 19
CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle
related to Structure · 18
CD80 → AA, APCs, B-cells, B7, Both, C2-type, CD28, CD86, CTLA-4, DC, Ig, Ig-like, It, Moreover, T-cells, The Ig-like, These, V-type
related to Function · 11
CD80 → APCs, B-cells, CD28, CTLA-4, However, In, Interaction, T-cell, T-cells, These, This
related to External links · 8
CD80 → Human CD80, Overview, P33681, PDB, PDBe-KB, T-lymphocyte, UCSC Genome Browser, UniProt
related to Clinical significance · 6
CD80 → HIV, Natural Killer, Others, T-cell, T-cells, The
Band · 2
CD80 → 16 B4|16 26.86 cM, 3q13.33
Chr. · 2
CD80 → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
CD80 → 119,559,614 bp, 38,316,697 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd28 t-cells also ctla-4 cd86 human interaction t-cell protein bp activation immune cells binding receptor chr b7 band chromosome cell

CD80 relationships Subject–Predicate–Object triples

TTTA extracted 137 structured relationships around CD80. Examples in this analysis include CD80 → Aliases → CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule and CD80 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD80AliasesCD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule1.00infobox
CD80Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L1.00infobox
CD80Band3q13.331.00infobox
CD80Band16 B4|16 26.86 cM1.00infobox
CD80Bgeetesticle1.00infobox
CD80Bgeelower lobe of lung1.00infobox
CD80Bgeepancreatic ductal cell1.00infobox
CD80Bgeetibialis anterior muscle1.00infobox
CD80Bgeeappendix1.00infobox
CD80Bgeelymph node1.00infobox
CD80Bgeespleen1.00infobox
CD80Bgeeupper lobe of lung1.00infobox
CD80Bgeeupper lobe of left lung1.00infobox
CD80Bgeemucosa of ileum1.00infobox
CD80Bgeegranulocyte1.00infobox
CD80Bgeestroma of bone marrow1.00infobox
CD80Bgeeembryo1.00infobox
CD80Bgeethymus1.00infobox
CD80Bgeesternocleidomastoid muscle1.00infobox
CD80Bgeevastus lateralis muscle1.00infobox
CD80Bgeeblood1.00infobox
CD80Bgeeendothelial cell of lymphatic vessel1.00infobox
CD80Bgeemajor salivary gland1.00infobox
CD80BioGPSn/a1.00infobox
CD80Chr.Chromosome 3 (human)1.00infobox
CD80Chr.Chromosome 16 (mouse)1.00infobox
CD80DatabasesNCBI: entry; OMA: entry1.00infobox
CD80End119,559,614 bp1.00infobox
CD80End38,316,697 bp1.00infobox
CD80EnsemblENSG000001215941.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD80 bring nearby vocabulary together. In this analysis, examples include Cd28, Interaction and T-cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD80
    • Cd28
    • Interaction
    • T-cells
    • Cd86
    • Ctla-4
    • T-cell
    • Cells
    • Human
    • Immune
    • Role
    • Binding
    • Cell
  • cd80
    • Cd28
    • Interaction
    • T-cells
    • Cd86
    • Ctla-4
    • T-cell
    • Cells
    • Human
    • Immune
    • Role
    • Binding
    • Cell
  • cd28
    • Ctla-4
    • Cd80
    • Interaction
    • Cd86
    • Cells
    • Costimulatory
    • Via
    • Interactions
    • Ligand
    • Receptor
    • Cell
    • Dendritic
  • binding sites
    • Differentiation
    • Receptor
    • Protein
    • External
    • Extracellular
    • Cd80
    • Band
    • Function
    • Gene
    • Location
    • Regulation
    • Surface
  • t helper cell
    • Activation
    • Receptor
    • Dendritic
    • Protein
    • Immune
    • T-cell
    • External
    • Interaction
    • T-cells
    • Function
    • Gene
    • Location
  • b7
    • External
    • Protein
    • Function
    • Gene
    • Location
    • Bp
    • Chr
    • Chromosome
    • Differentiation
    • Receptor
    • Binding
    • Human
  • immune cells
    • Interactions
    • Dendritic
    • Role
    • Protein
    • Regulation
    • Surface
    • Various
    • Cells
    • Immune
    • Ctla-4
    • Interaction
    • T-cells
  • function
    • Gene
    • Location
    • Bp
    • Chr
    • Chromosome
    • Protein
    • Human
    • Immune
    • T-cell
    • Band
    • Regulation
    • Surface

Connections between topic areas Semantic bridges

For CD80, one of the stronger structural bridges in this analysis connects CD80 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD80Function · splits 34 ⟂ 43
CD80Structure · splits 60 ⟂ 17
CD80Clinical significance · splits 68 ⟂ 9
CD80Overview · splits 70 ⟂ 7

Map overview Semantic statistics

CD80

Nodes77
Edges76
Triples137
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around CD80 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD80 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.