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The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with…
The analysis highlights Function, Structure and Clinical significance as prominent areas in the source structure around CD80.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CD80 shows recurring relationship patterns in the source. For example, CD80 → cell surface, cell surface receptor signaling pathway, cell-cell signaling, cellular response to lipopolysaccharide, coreceptor activity, cytokine-mediated signaling pathway, external side of plasma membrane, immune response, integral component of membrane, intracellular anatomical structure, intracellular signal transduction, membrane, negative regulation of T cell proliferation, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, plasma membrane, positive regulation of alpha-beta T cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein kinase B signaling, positive regulation of signal transduction Another extracted example is CD80 → appendix, blood, embryo, endothelial cell of lymphatic vessel, granulocyte, lower lobe of lung, lymph node, major salivary gland, mucosa of ileum, pancreatic ductal cell, spleen, sternocleidomastoid muscle, stroma of bone marrow, testicle, thymus, tibialis anterior muscle, upper lobe of left lung, upper lobe of lung, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cd28 t-cells also ctla-4 cd86 human interaction t-cell protein bp activation immune cells binding receptor chr b7 band chromosome cell
TTTA extracted 137 structured relationships around CD80. Examples in this analysis include CD80 → Aliases → CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule and CD80 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD80 | Aliases | CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule | 1.00 | infobox |
| CD80 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DR9, 1I8L | 1.00 | infobox |
| CD80 | Band | 3q13.33 | 1.00 | infobox |
| CD80 | Band | 16 B4|16 26.86 cM | 1.00 | infobox |
| CD80 | Bgee | testicle | 1.00 | infobox |
| CD80 | Bgee | lower lobe of lung | 1.00 | infobox |
| CD80 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| CD80 | Bgee | tibialis anterior muscle | 1.00 | infobox |
| CD80 | Bgee | appendix | 1.00 | infobox |
| CD80 | Bgee | lymph node | 1.00 | infobox |
| CD80 | Bgee | spleen | 1.00 | infobox |
| CD80 | Bgee | upper lobe of lung | 1.00 | infobox |
| CD80 | Bgee | upper lobe of left lung | 1.00 | infobox |
| CD80 | Bgee | mucosa of ileum | 1.00 | infobox |
| CD80 | Bgee | granulocyte | 1.00 | infobox |
| CD80 | Bgee | stroma of bone marrow | 1.00 | infobox |
| CD80 | Bgee | embryo | 1.00 | infobox |
| CD80 | Bgee | thymus | 1.00 | infobox |
| CD80 | Bgee | sternocleidomastoid muscle | 1.00 | infobox |
| CD80 | Bgee | vastus lateralis muscle | 1.00 | infobox |
| CD80 | Bgee | blood | 1.00 | infobox |
| CD80 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| CD80 | Bgee | major salivary gland | 1.00 | infobox |
| CD80 | BioGPS | n/a | 1.00 | infobox |
| CD80 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| CD80 | Chr. | Chromosome 16 (mouse) | 1.00 | infobox |
| CD80 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CD80 | End | 119,559,614 bp | 1.00 | infobox |
| CD80 | End | 38,316,697 bp | 1.00 | infobox |
| CD80 | Ensembl | ENSG00000121594 | 1.00 | infobox |
The concept neighborhoods around CD80 bring nearby vocabulary together. In this analysis, examples include Cd28, Interaction and T-cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CD80, one of the stronger structural bridges in this analysis connects CD80 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CD80 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD80 · EN edition · Analysis: TopicsToTalkAbout