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Immune checkpoint

Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. However, some cancers can protect themselves from attack by stimulating immune checkpoint targets.

Companies, Stimulatory checkpoint molecules & Inhibitory checkpoint molecules

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Stimulatory checkpoint molecules

Tumor necrosis factor (TNF) receptor superfamilyCD27CD70Th17Effector cell
27 related topics

Inhibitory checkpoint molecules

A2ARA2BRAdenosineTumor microenvironmentB7-H3
35 related topics

Overview

Immune systemSelf-toleranceCancer immunotherapyCheckpoint inhibitorsCTLA4
11 related topics

Immune checkpoint inhibitors (ICIs)

Merck
1 related topics

Topics to explore

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Overview

Stimulatory checkpoint molecules

Inhibitory checkpoint molecules

Immune checkpoint inhibitors (ICIs)

Advanced semantic analysis

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Map overview Semantic statistics

Immune checkpoint

Nodes79
Edges78
Triples12
Avg. degree1.97
Density0.025316
Components1

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Immune checkpoint

Top relations

related to Immune checkpoint inhibitors (ICIs) · 12
Immune checkpoint → Among, AstraZeneca, Bristol-Myers Squibb, Checkpoint, Drugs, ICB, ICIs, Merck, Merck KGaA, NSCLC, Roche, T-cell

Important terminology Word statistics

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Important terminology

cells immune checkpoint also cell molecule short receptor company expressed called ligand molecules known cd27 monoclonal target t-cell cancer system

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Drugs0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)ICB0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)ICIs0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)T-cell0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Among0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)NSCLC0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Checkpoint0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Bristol-Myers Squibb0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Merck0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Merck KGaA0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)Roche0.60section
Immune checkpointrelated to Immune checkpoint inhibitors (ICIs)AstraZeneca0.60section

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