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CD154: History & Art

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3.…

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CD154 topic overview

The analysis highlights History and Art as prominent areas in the source structure around CD154.

Related topics
48
Source areas
4
Connected nodes
52
Extracted relationships
134
Concept neighborhoods
24
Bridge connections
52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Specific effects on cells · 26 topics
Overview · 15 topics
History · 4 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD6
Band
Xq26.3 · X A6|X 31.21 cM
Bgee
granulocyte · lymph node · blood · appendix · rectum
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Specific effects on cells

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD154 connects Entity context

The extracted context around CD154 shows recurring relationship patterns in the source. For example, CD154 → B cell differentiation, B cell proliferation, CD40 receptor binding, cell surface, cytokine activity, external side of plasma membrane, extracellular region, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, isotype switching, leukocyte cell-cell adhesion, membrane, negative regulation of apoptotic process, plasma membrane, platelet activation, positive regulation of endothelial cell apoptotic process Another extracted example is CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD154

Top relations

Gene ontology · 31
CD154 → B cell differentiation, B cell proliferation, CD40 receptor binding, cell surface, cytokine activity, external side of plasma membrane, extracellular region, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, isotype switching, leukocyte cell-cell adhesion, membrane, negative regulation of apoptotic process, plasma membrane, platelet activation, positive regulation of endothelial cell apoptotic process
Bgee · 19
CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus
RNA expression pattern · 19
CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus
related to history · 13
CD154 → CD4, CD40-Ig, Columbia University, Dartmouth Medical School, Immunex, In, Lederman's, Leonard Chess, Michael Yellin, Noelle, Randolph Noelle, Richard Armitage, Seth Lederman
related to External links · 12
CD154 → Antigen, CD40LG, GeneReviews/NCBI/NIH/UW, Human CD40LG, Hyper-IgM, Immunodeficiency, Medicine Medical Subject Headings, MeSH, National Library, Type, UCSC Genome Browser, X-Linked Hyper IgM Syndrome
related to B cells · 8
CD154 → As, CD40, CD40L, Early, If, IL-4, TFH, The
related to Expression · 4
CD154 → CD4, CD40, NK, While CD40L
Band · 2
CD154 → X A6|X 31.21 cM, Xq26.3
Chr. · 2
CD154 → X chromosome (human), X chromosome (mouse)
End · 2
CD154 → 136,660,390 bp, 56,269,402 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells cd40 cell cd40l human bp gene chr band activated activation surface antibody expression endothelial also called tfh chromosome protein

CD154 relationships Subject–Predicate–Object triples

TTTA extracted 134 structured relationships around CD154. Examples in this analysis include CD154 → Aliases → CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand and CD154 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD154AliasesCD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand1.00infobox
CD154Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD61.00infobox
CD154BandXq26.31.00infobox
CD154BandX A6|X 31.21 cM1.00infobox
CD154Bgeegranulocyte1.00infobox
CD154Bgeelymph node1.00infobox
CD154Bgeeblood1.00infobox
CD154Bgeeappendix1.00infobox
CD154Bgeerectum1.00infobox
CD154Bgeespleen1.00infobox
CD154Bgeegallbladder1.00infobox
CD154Bgeemucosa of transverse colon1.00infobox
CD154Bgeebone marrow1.00infobox
CD154Bgeeepithelium of colon1.00infobox
CD154Bgeethymus1.00infobox
CD154BgeeMeckel's cartilage1.00infobox
CD154Bgeehip1.00infobox
CD154Bgeebones of pectoral girdle1.00infobox
CD154Bgeeshoulder1.00infobox
CD154Bgeehumerus1.00infobox
CD154Bgeeright kidney1.00infobox
CD154Bgeescapula1.00infobox
CD154Bgeejejunum1.00infobox
CD154BioGPSMore reference expression data1.00infobox
CD154Chr.X chromosome (human)1.00infobox
CD154Chr.X chromosome (mouse)1.00infobox
CD154DatabasesNCBI: entry; OMA: entry1.00infobox
CD154End136,660,390 bp1.00infobox
CD154End56,269,402 bp1.00infobox
CD154EnsemblENSG000001022451.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD154 bring nearby vocabulary together. In this analysis, examples include Cd40, Ligand and Expressed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD154
    • Cd40
    • Ligand
    • Expressed
    • Immune
    • Expression
    • Cells
    • External
    • Important
    • Therefore
    • Cd40lg
    • Effects
    • Germinal
  • cd154
    • Cd40
    • Ligand
    • Expressed
    • Immune
    • Expression
    • Cells
    • External
    • Important
    • Therefore
    • Cd40lg
    • Effects
    • Germinal
  • t cells
    • Cell
    • Helper
    • Endothelial
    • Antibody
    • Function
    • Protein
    • Tfh
    • Expression
    • Activation
    • Cd4
    • Effects
    • Ligand
  • cd40
    • Cd40l
    • Surface
    • Cell
    • Binds
    • Effects
    • Ligand
    • Expressed
    • Activation
    • Cells
    • External
    • Cd40lg
    • Chromosome
  • antigen-presenting cells
    • Cell
    • Helper
    • Endothelial
    • Antibody
    • Function
    • Protein
    • Tfh
    • Expression
    • Activation
    • Cd4
    • Effects
    • Ligand
  • t follicular helper cells
    • Antibody
    • Function
    • Protein
    • Tfh
    • Cell
    • Helper
    • Endothelial
    • Important
    • Expression
    • Activation
    • Cd4
    • Effects
  • b cell
    • Surface
    • Cells
    • Function
    • Activation
    • Maturation
    • Antibody
    • Expressed
    • Immune
    • Protein
    • Switching
    • Tfh
    • Human
  • immunoglobulin class switching
    • Germinal
    • Immune
    • Gene
    • External
    • Cd40lg
    • Cell
    • Effects
    • Igm
    • Maturation
    • Cd154
    • Cd40
    • Antibody

Connections between topic areas Semantic bridges

For CD154, one of the stronger structural bridges in this analysis connects CD154 with Specific effects on cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD154Specific effects on cells · splits 26 ⟂ 27
CD154Overview · splits 37 ⟂ 16
CD154History · splits 48 ⟂ 5
CD154Interactions · splits 49 ⟂ 4

Map overview Semantic statistics

CD154

Nodes53
Edges52
Triples134
Avg. degree1.96
Density0.037736
Components1

Source & methodology

TTTA analyzes the structure around CD154 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD154 · EN edition · Analysis: TopicsToTalkAbout

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