Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3.…
The analysis highlights History and Art as prominent areas in the source structure around CD154.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CD154 shows recurring relationship patterns in the source. For example, CD154 → B cell differentiation, B cell proliferation, CD40 receptor binding, cell surface, cytokine activity, external side of plasma membrane, extracellular region, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, isotype switching, leukocyte cell-cell adhesion, membrane, negative regulation of apoptotic process, plasma membrane, platelet activation, positive regulation of endothelial cell apoptotic process Another extracted example is CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cells cd40 cell cd40l human bp gene chr band activated activation surface antibody expression endothelial also called tfh chromosome protein
TTTA extracted 134 structured relationships around CD154. Examples in this analysis include CD154 → Aliases → CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand and CD154 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD6. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD154 | Aliases | CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand | 1.00 | infobox |
| CD154 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD6 | 1.00 | infobox |
| CD154 | Band | Xq26.3 | 1.00 | infobox |
| CD154 | Band | X A6|X 31.21 cM | 1.00 | infobox |
| CD154 | Bgee | granulocyte | 1.00 | infobox |
| CD154 | Bgee | lymph node | 1.00 | infobox |
| CD154 | Bgee | blood | 1.00 | infobox |
| CD154 | Bgee | appendix | 1.00 | infobox |
| CD154 | Bgee | rectum | 1.00 | infobox |
| CD154 | Bgee | spleen | 1.00 | infobox |
| CD154 | Bgee | gallbladder | 1.00 | infobox |
| CD154 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| CD154 | Bgee | bone marrow | 1.00 | infobox |
| CD154 | Bgee | epithelium of colon | 1.00 | infobox |
| CD154 | Bgee | thymus | 1.00 | infobox |
| CD154 | Bgee | Meckel's cartilage | 1.00 | infobox |
| CD154 | Bgee | hip | 1.00 | infobox |
| CD154 | Bgee | bones of pectoral girdle | 1.00 | infobox |
| CD154 | Bgee | shoulder | 1.00 | infobox |
| CD154 | Bgee | humerus | 1.00 | infobox |
| CD154 | Bgee | right kidney | 1.00 | infobox |
| CD154 | Bgee | scapula | 1.00 | infobox |
| CD154 | Bgee | jejunum | 1.00 | infobox |
| CD154 | BioGPS | More reference expression data | 1.00 | infobox |
| CD154 | Chr. | X chromosome (human) | 1.00 | infobox |
| CD154 | Chr. | X chromosome (mouse) | 1.00 | infobox |
| CD154 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CD154 | End | 136,660,390 bp | 1.00 | infobox |
| CD154 | End | 56,269,402 bp | 1.00 | infobox |
| CD154 | Ensembl | ENSG00000102245 | 1.00 | infobox |
The concept neighborhoods around CD154 bring nearby vocabulary together. In this analysis, examples include Cd40, Ligand and Expressed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CD154, one of the stronger structural bridges in this analysis connects CD154 with Specific effects on cells. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CD154 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Art, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD154 · EN edition · Analysis: TopicsToTalkAbout