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CD154

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3.…

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Specific effects on cells

26 related topics

History

4 related topics

Overview

15 related topics

Interactions

3 related topics

Key facts & relationships

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Aliases
CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD6
Band
Xq26.3 · X A6|X 31.21 cM
Bgee
granulocyte · lymph node · blood · appendix · rectum
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Overview

History

Specific effects on cells

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

CD154

Nodes53
Edges52
Triples134
Avg. degree1.96
Density0.037736
Components1

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CD154

Top relations

Gene ontology · 31
CD154 → B cell differentiation, B cell proliferation, CD40 receptor binding, cell surface, cytokine activity, external side of plasma membrane, extracellular region, extracellular space, immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, isotype switching, leukocyte cell-cell adhesion, membrane, negative regulation of apoptotic process, plasma membrane, platelet activation, positive regulation of endothelial cell apoptotic process
Bgee · 19
CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus
RNA expression pattern · 19
CD154 → appendix, blood, bone marrow, bones of pectoral girdle, epithelium of colon, gallbladder, granulocyte, hip, humerus, jejunum, lymph node, Meckel's cartilage, mucosa of transverse colon, rectum, right kidney, scapula, shoulder, spleen, thymus
related to history · 13
CD154 → CD4, CD40-Ig, Columbia University, Dartmouth Medical School, Immunex, In, Lederman's, Leonard Chess, Michael Yellin, Noelle, Randolph Noelle, Richard Armitage, Seth Lederman
related to External links · 12
CD154 → Antigen, CD40LG, GeneReviews/NCBI/NIH/UW, Human CD40LG, Hyper-IgM, Immunodeficiency, Medicine Medical Subject Headings, MeSH, National Library, Type, UCSC Genome Browser, X-Linked Hyper IgM Syndrome
related to B cells · 8
CD154 → As, CD40, CD40L, Early, If, IL-4, TFH, The
related to Expression · 4
CD154 → CD4, CD40, NK, While CD40L
Band · 2
CD154 → X A6|X 31.21 cM, Xq26.3
Chr. · 2
CD154 → X chromosome (human), X chromosome (mouse)
End · 2
CD154 → 136,660,390 bp, 56,269,402 bp

Important terminology Word statistics

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Important terminology

cells cd40 cell cd40l human bp gene chr band activated activation surface antibody expression endothelial also called tfh chromosome protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD154AliasesCD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand1.00infobox
CD154Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ALY, 1I9R, 3LKJ, 3QD61.00infobox
CD154BandXq26.31.00infobox
CD154BandX A6|X 31.21 cM1.00infobox
CD154Bgeegranulocyte1.00infobox
CD154Bgeelymph node1.00infobox
CD154Bgeeblood1.00infobox
CD154Bgeeappendix1.00infobox
CD154Bgeerectum1.00infobox
CD154Bgeespleen1.00infobox
CD154Bgeegallbladder1.00infobox
CD154Bgeemucosa of transverse colon1.00infobox
CD154Bgeebone marrow1.00infobox
CD154Bgeeepithelium of colon1.00infobox
CD154Bgeethymus1.00infobox
CD154BgeeMeckel's cartilage1.00infobox
CD154Bgeehip1.00infobox
CD154Bgeebones of pectoral girdle1.00infobox
CD154Bgeeshoulder1.00infobox
CD154Bgeehumerus1.00infobox
CD154Bgeeright kidney1.00infobox
CD154Bgeescapula1.00infobox
CD154Bgeejejunum1.00infobox
CD154BioGPSMore reference expression data1.00infobox
CD154Chr.X chromosome (human)1.00infobox
CD154Chr.X chromosome (mouse)1.00infobox
CD154DatabasesNCBI: entry; OMA: entry1.00infobox
CD154End136,660,390 bp1.00infobox
CD154End56,269,402 bp1.00infobox
CD154EnsemblENSG000001022451.00infobox

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