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CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.
The analysis highlights Function, Expression and Interactions as prominent areas in the source structure around CD27.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CD27 shows recurring relationship patterns in the source. For example, CD27 → apoptotic process, cell surface, cell surface receptor signaling pathway, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, external side of plasma membrane, extracellular region, extrinsic apoptotic signaling pathway, immune response, immunoglobulin mediated immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of T cell apoptotic process, plasma membrane, positive regulation of B cell differentiation, positive regulation of JNK cascade Another extracted example is CD27 → appendix, blood, bone marrow, bone marrow cell, duodenum, epithelium of small intestine, granulocyte, Ileal epithelium, intestinal villus, lymph node, mucosa of transverse colon, neck, pharynx, spermatid, spleen, testicle, thymus, tonsil. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp human receptor chr band cells gene expression chromosome 12 location drug clinical external mouse protein binds mutations target signaling
TTTA extracted 126 structured relationships around CD27. Examples in this analysis include CD27 → Aliases → CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule and CD27 → Band → 12p13.31. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CD27 | Aliases | CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule | 1.00 | infobox |
| CD27 | Band | 12p13.31 | 1.00 | infobox |
| CD27 | Band | 6 F3|6 59.32 cM | 1.00 | infobox |
| CD27 | Bgee | lymph node | 1.00 | infobox |
| CD27 | Bgee | spleen | 1.00 | infobox |
| CD27 | Bgee | appendix | 1.00 | infobox |
| CD27 | Bgee | bone marrow cell | 1.00 | infobox |
| CD27 | Bgee | granulocyte | 1.00 | infobox |
| CD27 | Bgee | blood | 1.00 | infobox |
| CD27 | Bgee | duodenum | 1.00 | infobox |
| CD27 | Bgee | testicle | 1.00 | infobox |
| CD27 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| CD27 | Bgee | tonsil | 1.00 | infobox |
| CD27 | Bgee | thymus | 1.00 | infobox |
| CD27 | Bgee | epithelium of small intestine | 1.00 | infobox |
| CD27 | Bgee | intestinal villus | 1.00 | infobox |
| CD27 | Bgee | Ileal epithelium | 1.00 | infobox |
| CD27 | Bgee | pharynx | 1.00 | infobox |
| CD27 | Bgee | bone marrow | 1.00 | infobox |
| CD27 | Bgee | spermatid | 1.00 | infobox |
| CD27 | Bgee | neck | 1.00 | infobox |
| CD27 | BioGPS | More reference expression data | 1.00 | infobox |
| CD27 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| CD27 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| CD27 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CD27 | End | 6,451,718 bp | 1.00 | infobox |
| CD27 | End | 125,213,973 bp | 1.00 | infobox |
| CD27 | Ensembl | ENSG00000139193 | 1.00 | infobox |
| CD27 | Entrez | 939 | 1.00 | infobox |
| CD27 | External IDs | OMIM: 186711; MGI: 88326; GeneCards: CD27 | 1.00 | infobox |
The concept neighborhoods around CD27 bring nearby vocabulary together. In this analysis, examples include Cells, External and Mutations. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CD27, one of the stronger structural bridges in this analysis connects CD27 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CD27 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Expression & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD27 · EN edition · Analysis: TopicsToTalkAbout