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CD27

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.

Function, Expression & Interactions

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Explore the main themes, entities and connections around CD27. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

13 related topics

Expression

9 related topics

Interactions

4 related topics

Clinical significance

2 related topics

Key facts & relationships

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Aliases
CD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule
Band
12p13.31 · 6 F3|6 59.32 cM
Bgee
lymph node · spleen · appendix · bone marrow cell · granulocyte
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Expression

Function

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

CD27

Nodes36
Edges35
Triples126
Avg. degree1.94
Density0.055556
Components1

How this topic connects Entity context

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CD27

Top relations

Gene ontology · 29
CD27 → apoptotic process, cell surface, cell surface receptor signaling pathway, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, external side of plasma membrane, extracellular region, extrinsic apoptotic signaling pathway, immune response, immunoglobulin mediated immune response, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of T cell apoptotic process, plasma membrane, positive regulation of B cell differentiation, positive regulation of JNK cascade
Bgee · 18
CD27 → appendix, blood, bone marrow, bone marrow cell, duodenum, epithelium of small intestine, granulocyte, Ileal epithelium, intestinal villus, lymph node, mucosa of transverse colon, neck, pharynx, spermatid, spleen, testicle, thymus, tonsil
RNA expression pattern · 18
CD27 → appendix, blood, bone marrow, bone marrow cell, duodenum, epithelium of small intestine, granulocyte, Ileal epithelium, intestinal villus, lymph node, mucosa of transverse colon, neck, pharynx, spermatid, spleen, testicle, thymus, tonsil
related to Function · 15
CD27 → Adaptor, B-cell, CD27-binding, CD70, It, MAPK8/JNK, NF-κB, SIVA, The, This, TNF-receptor, TRAF2, TRAF3, TRAF5, When CD27
related to Expression · 6
CD27 → CD31, During, Furthermore, Gata2, It, NK
related to External links · 6
CD27 → Antigens, Human CD27, Medicine Medical Subject Headings, MeSH, National Library, UCSC Genome Browser
related to Mutations · 5
CD27 → C53Y, C96Y, R107C, Some, Three
related to As a drug target · 4
CD27 → IgG1, The, This, Varlilumab
related to Interactions · 3
CD27 → SIVA1, TRAF2, TRAF3
Band · 2
CD27 → 12p13.31, 6 F3|6 59.32 cM

Important terminology Word statistics

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Important terminology

bp human receptor chr band cells gene expression chromosome 12 location drug clinical external mouse protein binds mutations target signaling

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD27AliasesCD27, S152, S152. LPFS2, T14, TNFRSF7, Tp55, CD27 molecule1.00infobox
CD27Band12p13.311.00infobox
CD27Band6 F3|6 59.32 cM1.00infobox
CD27Bgeelymph node1.00infobox
CD27Bgeespleen1.00infobox
CD27Bgeeappendix1.00infobox
CD27Bgeebone marrow cell1.00infobox
CD27Bgeegranulocyte1.00infobox
CD27Bgeeblood1.00infobox
CD27Bgeeduodenum1.00infobox
CD27Bgeetesticle1.00infobox
CD27Bgeemucosa of transverse colon1.00infobox
CD27Bgeetonsil1.00infobox
CD27Bgeethymus1.00infobox
CD27Bgeeepithelium of small intestine1.00infobox
CD27Bgeeintestinal villus1.00infobox
CD27BgeeIleal epithelium1.00infobox
CD27Bgeepharynx1.00infobox
CD27Bgeebone marrow1.00infobox
CD27Bgeespermatid1.00infobox
CD27Bgeeneck1.00infobox
CD27BioGPSMore reference expression data1.00infobox
CD27Chr.Chromosome 12 (human)1.00infobox
CD27Chr.Chromosome 6 (mouse)1.00infobox
CD27DatabasesNCBI: entry; OMA: entry1.00infobox
CD27End6,451,718 bp1.00infobox
CD27End125,213,973 bp1.00infobox
CD27EnsemblENSG000001391931.00infobox
CD27Entrez9391.00infobox
CD27External IDsOMIM: 186711; MGI: 88326; GeneCards: CD271.00infobox

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